Abstract：
:Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together with comparison of analogues. Compound (1) possess a (5/6/6/5) tetra-hetero-cyclic ring, whereas compound (2) contains a tricyclic system with an unusual bridged ring, which are the first report in Nature. The biological evaluation revealed that dendrocrepine (4) displayed a potent hypoglycemic effect in vitro.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu X,Chen X,Yang R,Li Z,Zhou H,Bai Y,Yu M,Li B,Ding Gdoi
10.1038/s41598-020-66552-2subject
Has Abstractpub_date
2020-06-12 00:00:00pages
9564issue
1issn
2045-2322pii
10.1038/s41598-020-66552-2journal_volume
10pub_type
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