Abstract:
INTRODUCTION:Early diagnosis and appropriate management of neonatal jaundice is crucial in avoiding severe hyperbilirubinemia and brain injury. A low-cost, minimally invasive, point-of-care (PoC) tool for total bilirubin (TB) estimation which can be useful across all ranges of bilirubin values and all settings is the need of the hour. OBJECTIVE:To assess the accuracy of Bilistick system, a PoC device, for measurement of TB in comparison with estimation by spectrophotometry. DESIGN/METHODS:In this cross-sectional clinical study, in infants who required TB estimation, blood samples in 25-µl sample transfer pipettes were collected at the same time from venous blood obtained for laboratory bilirubin estimation. The accuracy of Bilistick in estimating TB within ±2 mg/dl of bilirubin estimation by spectrophotometry was the primary outcome. RESULTS:Among the enrolled infants, 198 infants were eligible for study analysis with the mean gestation of 36 ± 2.3 weeks and the mean birth weight of 2368 ± 623 g. The median age at enrollment was 68.5 h (interquartile range: 48-92). Bilistick was accurate only in 54.5% infants in measuring TB within ±2 mg/dl difference of TB measured by spectrophotometry. There was a moderate degree of correlation between the two methods (r = 0.457; 95% CI: 0.339-0.561, p value < 0.001). Bland-Altman analysis showed a mean difference of 0.5 mg/dl (SD ± 4.4) with limits of agreement between -8.2 and +9.1 mg/dl. CONCLUSION:Bilistick as a PoC device is not accurate to estimate TB within the clinically acceptable difference (±2 mg/dl) of TB estimation by spectrophotometry and needs further improvement to make it more accurate.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Kamineni B,Tanniru A,Vardhelli V,Sharma D,Pawale D,Kulkarni D,Muppidi PR,Deshabhotla S,Murki Sdoi
10.1093/tropej/fmaa026subject
Has Abstractpub_date
2020-12-01 00:00:00pages
630-636issue
6eissn
0142-6338issn
1465-3664pii
5841166journal_volume
66pub_type
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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pub_type: 临床试验,杂志文章
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
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