Rickets in Nigerian children: response to calcium supplementation.

Abstract:

:In a previous study of rachitic children in Jos, Nigeria we concluded that inadequate dietary intake of calcium was the primary contributing factor to the development of their rickets. The objective of the present study was to determine the effect of calcium supplementation in 10 children with radiographically and biochemically proven rickets from the same geographical area. Rachitic children were provided with calcium supplements of 1000 mg/day for a period of 3 months. Serum and urine samples were obtained at baseline and at 24 hours, 1 week, 4 weeks, and 12 weeks after initiation of supplementation. Serum calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D were measured at each time point. Dietary recalls obtained at two separate times were used to estimate usual daily intakes of calcium and phosphorus. Ten non-rachitic age-matched controls from the same geographical area were recruited for comparison. Nine of 10 rachitic subjects had radiographic evidence of healing after 3 months of calcium therapy. Although serum calcium concentrations returned to control levels, other biochemical data indicated that the rickets of these subjects may have been multifactorial in aetiology, pointing to a possible defect in the synthesis of 25-hydroxyvitamin D.

journal_name

J Trop Pediatr

authors

Thacher T,Glew RH,Isichei C,Lawson JO,Scariano JK,Hollis BW,VanderJagt DJ

doi

10.1093/tropej/45.4.202

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

202-7

issue

4

eissn

0142-6338

issn

1465-3664

journal_volume

45

pub_type

临床试验,杂志文章
  • Use of Artificial Nipples Among Brazilian Infants and Associated Factors.

    abstract::Transversal study conducted in a Human Milk Bank to evaluate the factors associated with the use of artificial nipples (pacifier and/or nursing bottle) among Brazilian infants. Analyses were performed using the χ2 test and logistic regression analysis. A total of 6017 nursing mothers were evaluated and the use of arti...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmaa007

    authors: Miranda C,de Sousa TM,do Carmo AS,Pereira SCL,Notaro KAM,Dos Santos LC

    更新日期:2020-10-01 00:00:00

  • Bacteremia and malaria in Tanzanian children hospitalized for acute febrile illness.

    abstract::We recorded the reason for presentation to a rural hospital in an area endemic for malaria in 909 children between January 2006 and March 2009. Blood smears were examined for Plasmodium falciparum parasites, and blood spots dried on filter paper were prepared for 464 children. A PCR assay utilizing the stored blood sp...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmu069

    authors: Lundgren IS,Heltshe SL,Smith AL,Chibwana J,Fried MW,Duffy PE

    更新日期:2015-04-01 00:00:00

  • Milk-based cornstarch porridge fortified with iron is effective in reducing anemia: a randomized, double-blind, placebo-controlled trial.

    abstract::This study evaluates the impact of a milk-based cornstarch porridge fortified with iron, in 4-year olds, compared with control on hemoglobin levels and anemia prevalence. This trial was a cluster-randomized, double-blind one, and used milk-based cornstarch porridge fortified with 10 mg elemental iron (FeSO(4)), daily,...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/tropej/fms003

    authors: Arcanjo FP,Arcanjo CC,Arcanjo FC,Campos Lde A,Amancio OM,Braga JA

    更新日期:2012-10-01 00:00:00

  • Effects of displacement resulting from ethnic/religious conflict on the growth and body composition of Fulani children in northern Nigeria.

    abstract::This study, which was carried out in the Jos Plateau in Nigeria, analysed the changes in growth and body composition that occurred among 17 male and 13 female Fulani children (aged 4-13 years) in the 7-month period which followed their displacement from their homes into a temporary camp due to ethnic/religious violenc...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.5.279

    authors: Glew RH,Bhanji RA,VanderJagt DJ

    更新日期:2003-10-01 00:00:00

  • The epidemiological and clinical characteristics of diarrhea associated with enteropathogenic, enteroaggregative and diffuse-adherent Escherichia coli in Egyptian children.

    abstract::A total of 220 enteroadherent Escherichia coli were identified from 729 Egyptian children with diarrhea using the HEp-2 adherence assay. Enteropathogenic E.coli (EPEC = 38) was common among children <6 months old and provoked vomiting, while diffuse-adhering E.coli (DAEC = 109) induced diarrheal episodes of short dura...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmu034

    authors: Ahmed SF,Shaheen HI,Abdel-Messih IA,Mostafa M,Putnam SD,Kamal KA,Sayed AN,Frenck RW Jr,Sanders JW,Klena JD,Wierzba TF

    更新日期:2014-10-01 00:00:00

  • Birthweight and gestational age as predictors of outcome in preterm deliveries for severe pre-eclampsia.

    abstract::The aim of this study was to compare the neonatal outcomes of babies with birthweights < 10th centile to those with birthweights > or = 10th centile with a gestational age of 28-34 weeks. This retrospective hospital-based study was performed at a tertiary referral centre. All women with early, severe pre-eclampsia, ma...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.3.178

    authors: Hall D

    更新日期:2003-06-01 00:00:00

  • Impact of prematurity on admissions to the neonatal nursery of a rural South African district hospital.

    abstract::The objectives of this study were to determine causes of admission to a district hospital neonatal nursery; to describe outcomes; and to determine risk factors for these outcomes. The study was based at the neonatal nursery of Hlabisa hospital, KwaZulu/Natal; 149 consecutive admissions to the nursery between May and N...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/45.2.76

    authors: Wilkinson D,Connolly C,Stirling S

    更新日期:1999-04-01 00:00:00

  • Children with human immunodeficiency virus infection admitted to a paediatric intensive care unit in South Africa.

    abstract:BACKGROUND:Early data regarding the outcome of human immunodeficiency virus (HIV)-infected children in paediatric intensive care units (PICU) suggested mortality as high as 100%. Recent studies report mortality of 38%. Survival depends on the indication for admission. OBJECTIVES:To describe the prevalence, duration of...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmm036

    authors: Rabie H,de Boer A,van den Bos S,Cotton MF,Kling S,Goussard P

    更新日期:2007-08-01 00:00:00

  • Heated Humidified High-Flow Nasal Cannula vs. Nasal Continuous Positive Airway Pressure for Post-extubation Respiratory Support in Preterm Infants: A Randomized Controlled Trial.

    abstract:OBJECTIVE:The objective of this study was to compare the efficacy and safety of heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP) for prevention of extubation failure in preterm infants. METHODS:Preterm infants (gestation ≥28 weeks) were randomized to HHHFNC or nC...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmaa082

    authors: Yengkhom R,Suryawanshi P,Gupta B,Deshpande S

    更新日期:2020-11-11 00:00:00

  • Attitudes towards end-of-life issues amongst pediatricians in a tertiary hospital in a developing country.

    abstract::To describe the perspectives of pediatricians from a tertiary care center from India on end-of-life (EOL) care issues, a standardized anonymous questionnaire was administered, which included questions regarding attitudes towards withdrawal/withholding of life-sustaining treatment in children and neonates at the EOL, a...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmn009

    authors: Guglani L,Lodha R

    更新日期:2008-08-01 00:00:00

  • Clinical and anthropometric profile of children with celiac disease in Punjab (North India).

    abstract::This prospective study was carried out to evaluate the clinical and anthropometric profile of 71 children confirmed to have celiac disease on the basis of clinical features, duodenal biopsy and unequivocal improvement on gluten-free diet. Serological tests were performed in 35 cases. The patients were divided into thr...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmi054

    authors: Pooni PA,Chhina RS,Jaina BK,Singh D,Gautam A

    更新日期:2006-02-01 00:00:00

  • Circulating growth hormone (GH), insulin-like growth factor-I (IGF-I) and free thyroxine, GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle cell disease.

    abstract::Serum growth hormone (GH), cortisol, free thyroxine (FT4), thyroid-stimulating hormone (TSH), and insulin like growth factor I (IGF-I) concentrations were measured in 15 children with sickle cell disease (SCD) together with their heights < 5th percentile for age and gender, and in 15 healthy age-matched children who h...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/41.5.285

    authors: Soliman AT,Darwish A,Mohammed SH,Bassiony MR,el Banna N,Asfour M

    更新日期:1995-10-01 00:00:00

  • Correlation between clinical diagnoses at the time of death and autopsy findings in critically sick neonates at a regional neonatal intensive care unit in India.

    abstract::This study was carried out to examine the correlation between clinical diagnoses at the time of death and autopsy findings in newborn babies who died in the regional Neonatal Intensive Care Unit (NICU) of King Edward VII Memorial Hospital affiliated to Bombay University. A consecutive sample of 240 newborns that died ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/47.5.295

    authors: Kabra NS,Udani RH

    更新日期:2001-10-01 00:00:00

  • High cost is the primary barrier reported by physicians who prescribe vaccines not included in India's Universal Immunization Program.

    abstract::Haemophilus influenzae type B (Hib) vaccine, pneumococcal conjugate vaccine (PCV) and rotavirus (RV) vaccine are available in the private market in India, but, except for Hib in eight states, are not included in India's Universal Immunization Program (UIP). Pediatricians were surveyed about administering non-UIP vacci...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmu012

    authors: Kahn GD,Thacker D,Nimbalkar S,Santosham M

    更新日期:2014-08-01 00:00:00

  • Immunological spectrum of childhood tuberculosis.

    abstract::Fifty-three children with tuberculous meningitis (TBM) were studied in parallel with 37 children with primary pulmonary complex (PPC), 32 tuberculin skin positive controls, and 38 skin negative controls for immunological evaluation. Proportions of peripheral blood total T and T helper lymphocytes (TH) were significant...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/38.1.31

    authors: Rajajee S,Narayanan PR

    更新日期:1992-02-01 00:00:00

  • Severe Multisystem Involvement of Chronic Granulomatous Disease in a Pediatric Patient.

    abstract::Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder identified by recurrent pyogenic and fungal infections infections secondary to defective nicotinamide adenine dinucleotide phosphate oxidase enzyme. In the present study, we demonstrated a case with a history of multiple segmental lung res...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmy022

    authors: Bayramoglu Z,Adaletli I,Caliskan E,Acar M,Hancerli Torun S,Somer A

    更新日期:2019-04-01 00:00:00

  • Clinical validation of a western blot assay for congenital toxoplasmosis and newborn screening in a hospital in Armenia (Quindio) Colombia.

    abstract::Congenital Toxoplasma infection can only be discovered or prevented by the appropriate serological screening and subsequent treatment of the mother and her offspring. In Colombia, there is no obligatory Toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is li...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmi072

    authors: Gallego-Marín C,Henao AC,Gómez-Marín JE

    更新日期:2006-04-01 00:00:00

  • Quality of survivals on conservative neonatal care.

    abstract::Quantity as well as quality of survivals determine the performance of a neonatal centre. Our centre has succeeded in improving survival with low cost technology without compromising the quality. Neurodevelopmental handicap was low on a 1-year follow-up. No baby had retinopathy of prematurity or hearing deficit. Dropou...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/37.5.250

    authors: Kadam SB,Daga SR,Daga AS

    更新日期:1991-10-01 00:00:00

  • A study of the use of the Nicaraguan antenatal card.

    abstract::The present study describes the use of a home-based antenatal card in a sample of 120 consecutive women who were giving birth at a large teaching hospital in the city of León, Nicaragua. Information was obtained by interviews with the women before leaving hospital and all data on their antenatal cards and regarding de...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/40.3.133

    authors: Laurell L,Essén B,Peña R,Ostergren PO,Liljestrand J

    更新日期:1994-06-01 00:00:00

  • Feeding and nutritional characteristics of infants on PMTCT programs.

    abstract:OBJECTIVES:To compare feeding and nutritional characteristics of infants born to mothers on the prevention of mother to child transmission (PMTCT) programs with infants not in the program. DESIGN:A hospital-based case-control study was used. SETTING:The study was conducted in Nsambya hospital, Kampala, Uganda. SUBJE...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmn071

    authors: Magezi SR,Kikafunda J,Whitehead R

    更新日期:2009-02-01 00:00:00

  • Testicular Schistosomiasis Mimicking Malignancy in a Child: A Case Report.

    abstract::Schistosomiasis is an important communicable disease in the developing world. However, testicular schistosomiasis is an extremely rare condition. We report a case of testicular schistosomiasis mimicking testicular tumour in a 13 year old who presented with huge unilateral testicular mass. The dilemma encountered in th...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmv041

    authors: Ekenze SO,Modekwe VO,Nzegwu MA,Ekpemo SC,Ezomike UO

    更新日期:2015-08-01 00:00:00

  • Preliminary assessment of breastfeeding practices in HIV 1-infected mothers (prior to weaning) under the Djoungolo programme on the prevention of mother-to-child transmission of HIV.

    abstract:BACKGROUND:Human Immunodeficiency virus (HIV) transmission in a breastfeeding population varies from 20% to 45%. OBJECTIVE:To evaluate breastfeeding practices and the early basic HIV transmission rate in HIV-exposed children in the Djoungolo health district (prevention of mother-to-child transmission HIV programme). ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmq018

    authors: Nlend AE,Ekani BB

    更新日期:2010-12-01 00:00:00

  • Influence of health providers on pediatrics' immunization rate.

    abstract::To identify the immunization providers' characteristics associated with immunization rate in children younger than 2 years. A cohort and a cluster sampling design were implemented; 528 children between 18 and 70 months of age were sampled in five public health clinics in Mosul-Iraq. Providers' characterizations were o...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fms014

    authors: Al-lela OQ,Baidi Bahari M,Al-abbassi MG,Salih MR,Basher AY

    更新日期:2012-12-01 00:00:00

  • Nutritional status, migration, mortality, and measles vaccine coverage during the 1983-1985 drought period: Timbuktu, Mali.

    abstract::Mali was affected by the drought across the Sahel in 1983-1985. The present study describes the demographic and nutritional status in the Timbuktu region in May 1985, and contributes to the little data available for Mali during this period; malnutrition rates are compared to two other drought affected areas in the Sah...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/36.3.109

    authors: Carnell MA,Guyon AB

    更新日期:1990-06-01 00:00:00

  • Iron status of adolescent females in three schools in an urban area of Sri Lanka.

    abstract::Ninety-three females in the age group 14-18 years were randomly selected from three schools in Colombo. Their iron and nutritional status was assessed using clinical, anthropometric, haematological, and biochemical parameters. Haemoglobin levels less than 12 g/dl were seen in 3.7 per cent of adolescent females. Free e...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/36.6.316

    authors: Atukorala TM,de Silva LD

    更新日期:1990-12-01 00:00:00

  • Toxoplasmosis in young Jamaicans.

    abstract::Of 511 young (1-19 years of age) Jamaicans sampled for IgG antibodies to Toxoplasma by the ELISA method, there was an overall prevalence of 45 per cent. Seropositivity ranged from 24-26 per cent in the 2-year-olds, up to 54 per cent in the 5-9-year-olds. There was no significant difference in prevalence between the se...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.5.234

    authors: Rawlins SC,Prabhakar P

    更新日期:1989-10-01 00:00:00

  • Longitudinal study in biochemical composition of human milk during first year of lactation.

    abstract::The composition (total solids, total protein, casein, coagulable proteins, lactose, fat, and ash) and mineral content (calcium, phosphorus, sodium, potassium, magnesium, zinc, and copper) of human milk was estimated longitudinally for the first year of lactation. Concentration of various nutrients, except zinc and cop...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.3.126

    authors: Nagra SA

    更新日期:1989-06-01 00:00:00

  • Post-neonatal Tetanus in a PICU of a Developing Economy: Intensive Care Needs, Outcome and Predictors of Mortality.

    abstract:Objectives:To evaluate pediatric intensive care unit (PICU) needs, outcome and predictors of mortality in post-neonatal tetanus. Materials and methods:Review of 30 consecutive post-neonatal tetanus cases aged 1 months to 12 years admitted to a PICU in north India over a period of 10 years (January 2006 to December 201...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmx020

    authors: Angurana SK,Jayashree M,Bansal A,Singhi S,Nallasamy K

    更新日期:2018-02-01 00:00:00

  • Serum immunoglobulin E in idiopathic nephrotic syndrome.

    abstract::Serum immunoglobulin E (IgE) and absolute eosinophil count (AEC) were assayed in 48 children with idiopathic nephrotic syndrome and 20 controls. The mean serum IgE (p < 0.001) and AEC (p < 0.05) were significantly raised in active nephrotic syndrome compared with controls. The mean values of IgE and AEC in nephrotic p...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/50.3.149

    authors: Mishra OP,Ibrahim N,Usha,Das BK

    更新日期:2004-06-01 00:00:00

  • Prevalence and Outcome of Sepsis-induced Myocardial Dysfunction in Children with 'Sepsis' 'With' and 'Without Shock'-A Prospective Observational Study.

    abstract:Objective:To estimate the prevalence and effects of sepsis-induced myocardial dysfunction (SIMD) in children with septic shock. Methodology:Enrolled children with septic shock (n = 31) and sepsis (n = 30) underwent echocardiography and cardiac troponin-I (cTnI) estimation within first 3 h. SIMD was defined as presence...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmx105

    authors: Jain A,Sankar J,Anubhuti A,Yadav DK,Sankar MJ

    更新日期:2018-12-01 00:00:00