High-dose intravenous immunoglobulin downregulates the activated levels of inflammatory indices except erythrocyte sedimentation rate in acute stage of Kawasaki Disease.

Abstract:

:We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory indices were performed three times: before IVIG treatment, 24 h after IVIG treatment, and 7 days after IVIG treatment. The white blood cell and neutrophil counts showed significant decreases 24 h and 7 days after IVIG administration. The erythrocyte sedimentation rate (ESR) increased significantly 24 h after IVIG, and the elevated level was sustained for 7 days. The levels of hemoglobin, albumin and inflammation-associated proteins, including C-reactive protein, decreased 24 h after IVIG treatment. Inflammation-associated proteins, except transferrin, decreased further to near normal levels after 7 days. On the other hand, IgM and IgA were not affected after 24 h, rather increased significantly after 7 days. High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD.

journal_name

J Trop Pediatr

authors

Lee KY,Lee HS,Hong JH,Han JW,Lee JS,Whang KT

doi

10.1093/tropej/fmh087

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

98-101

issue

2

eissn

0142-6338

issn

1465-3664

pii

fmh087

journal_volume

51

pub_type

临床试验,杂志文章
  • Community management of anti-malarials in Africa and iatrogenic risk.

    abstract::Distribution of anti-malarials at the community level is one of the interventions recommended to reduce mortality from febrile illnesses. Inappropriate treatment of fever with anti-malarials may result in missed diagnosis and delays in appropriate treatments including consideration of other illnesses than malaria. We ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmq074

    authors: Orostegui L,Balu L,Chevret L,Habes D,Pussard E

    更新日期:2011-06-01 00:00:00

  • Effects of displacement resulting from ethnic/religious conflict on the growth and body composition of Fulani children in northern Nigeria.

    abstract::This study, which was carried out in the Jos Plateau in Nigeria, analysed the changes in growth and body composition that occurred among 17 male and 13 female Fulani children (aged 4-13 years) in the 7-month period which followed their displacement from their homes into a temporary camp due to ethnic/religious violenc...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.5.279

    authors: Glew RH,Bhanji RA,VanderJagt DJ

    更新日期:2003-10-01 00:00:00

  • Epidemiology of systemic candidiasis in a tertiary care neonatal unit.

    abstract::143 neonates were diagnosed to have acquired systemic candidiasis out of a total 4530 admissions (3.2 per cent) to the neonatal intensive care unit (NICU) during a period of 6 1/2 years from January 1990 to June 1996. Mean age at onset was 10.4 days, mean birth weight 1454 g, and mean gestation was 31.7 weeks. Ninety-...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/44.2.104

    authors: Narang A,Agrawal PB,Chakrabarti A,Kumar P

    更新日期:1998-04-01 00:00:00

  • Prevention and early detection of leprosy in children.

    abstract::India with its 4 million cases of leprosy, accounts for one-third of the world's population of leprosy patients. One-fourth of them are below 15 years of age. We report a 5-year follow-up study of healthy children who were close contacts of leprosy patients, in order to: 1. detect subclinical infection and observe the...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/41.3.132

    authors: Dayal R,Bharadwaj VP

    更新日期:1995-06-01 00:00:00

  • A Valuable Tool in Predicting Poor Outcome due to Sepsis in Pediatric Intensive Care Unit: Tp-e/QT Ratio.

    abstract:OBJECTIVE:To assess the feasibility of 12-lead electrocardiographic (ECG) measures such as P wave dispersion (PWd), QT interval, QT dispersion (QTd), Tp-e interval, Tp-e/QT and Tp-e/QTc ratio in predicting poor outcome in patients diagnosed with sepsis in pediatric intensive care unit (PICU). METHODS:Ninety-three pati...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmw021

    authors: Ozdemir R,Isguder R,Kucuk M,Karadeniz C,Ceylan G,Katipoglu N,Yilmazer MM,Yozgat Y,Mese T,Agin H

    更新日期:2016-10-01 00:00:00

  • The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice.

    abstract::Increased bilirubin formation and decreased bilirubin conjugation play an important role in the pathogenesis of the newborn jaundice. Although physiologic jaundice is seen in most of the newborns, there are many risk factors that affect the severity and duration of hyperbilirubinemia. The latest studies showed that th...

    journal_title:Journal of tropical pediatrics

    pub_type: 信件

    doi:10.1093/tropej/fml067

    authors: Muslu N,Turhan AB,Eskandari G,Atici A,Ozturk OG,Kul S,Atik U

    更新日期:2007-02-01 00:00:00

  • The epidemiological and clinical characteristics of diarrhea associated with enteropathogenic, enteroaggregative and diffuse-adherent Escherichia coli in Egyptian children.

    abstract::A total of 220 enteroadherent Escherichia coli were identified from 729 Egyptian children with diarrhea using the HEp-2 adherence assay. Enteropathogenic E.coli (EPEC = 38) was common among children <6 months old and provoked vomiting, while diffuse-adhering E.coli (DAEC = 109) induced diarrheal episodes of short dura...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmu034

    authors: Ahmed SF,Shaheen HI,Abdel-Messih IA,Mostafa M,Putnam SD,Kamal KA,Sayed AN,Frenck RW Jr,Sanders JW,Klena JD,Wierzba TF

    更新日期:2014-10-01 00:00:00

  • Birthweight and gestation of village deliveries in Papua New Guinea.

    abstract::This study investigates the birthweight, gestational age, and body proportions of home births in a malarious area of Papua New Guinea. A population based cohort of pregnant women was followed longitudinally through pregnancy. Within the first few days of birth anthropometric measures were taken and a gestational age a...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/40.1.37

    authors: Garner P,Dubowitz L,Baea M,Lai D,Dubowitz M,Heywood P

    更新日期:1994-02-01 00:00:00

  • CD4+ T-lymphocyte count/CD8+ T-lymphocyte count ratio: surrogate for HIV infection in infants?

    abstract:INTRODUCTION:Early diagnosis and treatment is necessary to prevent HIV-infected infants progressing to AIDS. Antibody testing is not confirmatory before the age of 18 months and PCR not widely available in resource-poor settings. We studied the accuracy of CD4(+) T-lymphocyte count, CD4% and CD4/CD8 ratio as surrogate ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmr102

    authors: Navaneethapandian PG,Karunaianantham R,Subramanyan S,Chinnayan P,Chandrasekaran P,Swaminathan S

    更新日期:2012-10-01 00:00:00

  • Angiopoietin-1 and endostatin levels in cord plasma predict the development of bronchopulmonary dysplasia in preterm infants.

    abstract:OBJECTIVE:To determine whether angiopoietin-1 and endostatin levels in the cord blood could predict the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants. PATIENTS AND METHODS:A total of 102 preterm (gestational age ≤ 32 weeks) infants (28 infants developed BPD and 74 had no BPD) were enrol...

    journal_title:Journal of tropical pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1093/tropej/fmq112

    authors: Mohamed WA,Niyazy WH,Mahfouz AA

    更新日期:2011-10-01 00:00:00

  • Influence of health providers on pediatrics' immunization rate.

    abstract::To identify the immunization providers' characteristics associated with immunization rate in children younger than 2 years. A cohort and a cluster sampling design were implemented; 528 children between 18 and 70 months of age were sampled in five public health clinics in Mosul-Iraq. Providers' characterizations were o...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fms014

    authors: Al-lela OQ,Baidi Bahari M,Al-abbassi MG,Salih MR,Basher AY

    更新日期:2012-12-01 00:00:00

  • Milk-based cornstarch porridge fortified with iron is effective in reducing anemia: a randomized, double-blind, placebo-controlled trial.

    abstract::This study evaluates the impact of a milk-based cornstarch porridge fortified with iron, in 4-year olds, compared with control on hemoglobin levels and anemia prevalence. This trial was a cluster-randomized, double-blind one, and used milk-based cornstarch porridge fortified with 10 mg elemental iron (FeSO(4)), daily,...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/tropej/fms003

    authors: Arcanjo FP,Arcanjo CC,Arcanjo FC,Campos Lde A,Amancio OM,Braga JA

    更新日期:2012-10-01 00:00:00

  • Preliminary assessment of breastfeeding practices in HIV 1-infected mothers (prior to weaning) under the Djoungolo programme on the prevention of mother-to-child transmission of HIV.

    abstract:BACKGROUND:Human Immunodeficiency virus (HIV) transmission in a breastfeeding population varies from 20% to 45%. OBJECTIVE:To evaluate breastfeeding practices and the early basic HIV transmission rate in HIV-exposed children in the Djoungolo health district (prevention of mother-to-child transmission HIV programme). ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmq018

    authors: Nlend AE,Ekani BB

    更新日期:2010-12-01 00:00:00

  • Salmonella septicaemias in Kenyan children.

    abstract::In a 5-month study of Salmonella septicaemias in Kenyan children carried out during the annual peak infection period, Salmonella typhimurium septicaemias occurred seven times more frequently than typhoid or other non-typhoid infections. Salmonella typhimurium infections were predominantly community acquired, malnouris...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.1.35

    authors: Nesbitt A,Mirza NB

    更新日期:1989-02-01 00:00:00

  • Severe Multisystem Involvement of Chronic Granulomatous Disease in a Pediatric Patient.

    abstract::Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder identified by recurrent pyogenic and fungal infections infections secondary to defective nicotinamide adenine dinucleotide phosphate oxidase enzyme. In the present study, we demonstrated a case with a history of multiple segmental lung res...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmy022

    authors: Bayramoglu Z,Adaletli I,Caliskan E,Acar M,Hancerli Torun S,Somer A

    更新日期:2019-04-01 00:00:00

  • Helicobacter pylori infection and recurrent abdominal pain in children.

    abstract::The association of Helicobacter pylori infection with recurrent abdominal pain (RAP) was studied in 65 children aged between 3 and 12 years. Cases with a specific cause for abdominal pain were excluded from the study. All the patients were subjected to upper gastrointestinal endoscopy and antral biopsy. The biopsy spe...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.4.250

    authors: Das BK,Kakkar S,Dixit VK,Kumar M,Nath G,Mishra OP

    更新日期:2003-08-01 00:00:00

  • Assessment of drinking water fortification with iron plus ascorbic Acid or ascorbic Acid alone in daycare centers as a strategy to control iron-deficiency anemia and iron deficiency: a randomized blind clinical study.

    abstract:OBJECTIVE:Assess drinking water fortification with iron and/or ascorbic acid as a strategy to control iron-deficiency anemia and iron deficiency. METHODS:Randomized blind clinical study, fortifying drinking water to 153 pre-school children during 3 months, with iron and ascorbic acid (A), ascorbic acid (B) or plain wa...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/tropej/fmt071

    authors: de Almeida CA,De Mello ED,Ramos AP,João CA,João CR,Dutra-de-Oliveira JE

    更新日期:2014-02-01 00:00:00

  • Breastfeeding and supplemental feeding for neonates in Al-Ain, United Arab Emirates.

    abstract::A prospective cohort study was carried out to determine the factors affecting initiation of breastfeeding, and describe patterns of breastfeeding and supplemental feeding in the multiethnically and culturally diverse population of Al Ain, UAE. Two-hundred-and-twenty-one infants completed the 4 weeks of follow up. None...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/43.5.304

    authors: al-Mazroui MJ,Oyejide CO,Bener A,Cheema MY

    更新日期:1997-10-01 00:00:00

  • Myocarditis Prevalence in Paediatric Dengue Infection: A Prospective Study in Tertiary Hospital in Yogyakarta, Indonesia.

    abstract::Awareness of cardiac involvement in dengue infection has potentially valuable management implications. To determine the prevalence of myocarditis in dengue severity, we conducted prospective study of paediatric dengue illness at Dr. Sardjito General Hospital, a tertiary hospital in Yogyakarta, Indonesia, from period o...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmz020

    authors: Buntubatu S,Prawirohartono EP,Arguni E

    更新日期:2019-12-01 00:00:00

  • A visual dosing aid for first-line pediatric antiretroviral treatment in resource-poor settings.

    abstract::The visual dosing aid (VDA) was developed to facilitate dosing calculations in response to children's; growth and weight during antiretroviral treatment. The theoretical accuracy of the VDA was assessed using anthropometric data from 55 children receiving care in the USA and 324 children in the Democratic Republic of ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmn095

    authors: Callens SF,Westreich D,Kitetele F,Lusiama J,Shabani N,Belhorn T,Colebunders R,Behets F,Van Rie A

    更新日期:2009-04-01 00:00:00

  • Liquid crystal thermometry for the detection of neonatal hypothermia in Nepal.

    abstract::We assessed the sensitivity, specificity and likelihood ratio of a low cost liquid crystal strip thermometer (LCT) compared with axillary mercury thermometry for the detection of neonatal hypothermia in Nepal. The subjects were 76 healthy newborns in the government maternity hospital of Kathmandu, Nepal in winter. The...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/44.1.15

    authors: Manandhar N,Ellis M,Manandhar DS,Morley D,de L Costello AM

    更新日期:1998-02-01 00:00:00

  • Alpha thalassaemia in Yemeni children with sickle cell disease.

    abstract::Alpha thalassaemia frequently occurs in several of the Middle Eastern populations. This study was conducted on 26 sickle cell disease (SCD) patients from Yemen and 19 normal children (Hb AA) living in Riyadh, Saudi Arabia. Blood samples were extracted by venepuncture, and haematological and biochemical parameters were...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/45.6.370

    authors: el-Hazmi MA,Warsy AS

    更新日期:1999-12-01 00:00:00

  • Severe vitamin B12 deficiency in a breast fed infant with pancytopenia.

    abstract::We report the case of a 7-month-old breast fed infant who presented with a nose bleed and bruises. Investigation showed severe nutritional B12 deficiency anemia with a pancytopenia. It is important to take the nutritional history of both the infant and the mother for early prevention and treatment. ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmp039

    authors: Citak FE,Citak EC

    更新日期:2011-02-01 00:00:00

  • Alarmingly High Incidence of Eosinophilia in Barabanki and Neighboring Districts of Eastern Uttar Pradesh: A Prospective Hospital-Based Study.

    abstract::Eosinophilia is very common among rural poulation in Barabanki and neighbouring districts with no access to hygienic mode of stool disposition. Significant proportions of these children are suffering from anemia, undernutrition, anorexia, pain abdomen, cough and hence long term morbidity. This adds to the DALY of a de...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmw035

    authors: Thakur N,Rai N

    更新日期:2016-12-01 00:00:00

  • Selenium Supplementation for Prevention of Late-Onset Sepsis in Very Low Birth Weight Preterm Neonates.

    abstract:BACKGROUND:Neonatal mortality continues to be a significant problem in the Indian setting, especially in very low birth weight (VLBW) neonates. Selenium (Se) has been shown to possess antioxidant properties, and some recent studies have shown a reduction in the sepsis-attributable neonatal mortality with its use. India...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/tropej/fmv096

    authors: Aggarwal R,Gathwala G,Yadav S,Kumar P

    更新日期:2016-06-01 00:00:00

  • High prevalence of infantile encephalitic beriberi with overlapping features of Leigh's disease.

    abstract::Infantile encephalitic beriberi (IEBB) is a rare form of thiamine deficiency and is poorly described. A proportion of Leigh's disease (LD) patients have similar clinical picture and response to thiamine as beriberi, leading to confusion in diagnosis and management. Data on IEBB and LD is scarce and status of thiamine ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmn031

    authors: Rao SN,Mani S,Madap K,Kumar MV,Singh L,Chandak GR

    更新日期:2008-10-01 00:00:00

  • Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria.

    abstract::Congenital malaria, defined as the presence of malaria parasites in the erythrocytes of newborns aged <7 days, was considered rare in endemic areas until recent studies started reporting high prevalence rates. Various theories have been postulated to explain this phenomenon, but they are not proven conclusively from r...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmn016

    authors: Sotimehin SA,Runsewe-Abiodun TI,Oladapo OT,Njokanma OF,Olanrewaju DM

    更新日期:2008-10-01 00:00:00

  • Vitamin A status and nutritional intake of carotenoids of preschool children in Ijaye Orile community in Nigeria.

    abstract::This study was carried out to determine the vitamin A status and nutritional intake of carotenoids of 213 children between the ages of 6 months and 6 years in a rural community in Nigeria. There were 109 males and 104 females. A total of 57 (26.8 per cent) children were deficient in serum retinol levels (< 10 microg/d...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.1.42

    authors: Oso OO,Abiodun PO,Omotade OO,Oyewole D

    更新日期:2003-02-01 00:00:00

  • Therapeutic hypothermia using gel packs for term neonates with hypoxic ischaemic encephalopathy in resource-limited settings: a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate the efficacy of therapeutic hypothermia (TH) using gel packs in reducing mortality and morbidity in term neonates with HIE and study the associated problems with TH. METHODS:Hypoxic ischaemic encephalopathy babies were randomized into TH and control group. Babies in TH group were cooled for first...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/tropej/fms005

    authors: Bharadwaj SK,Bhat BV

    更新日期:2012-10-01 00:00:00

  • Toxoplasmosis in young Jamaicans.

    abstract::Of 511 young (1-19 years of age) Jamaicans sampled for IgG antibodies to Toxoplasma by the ELISA method, there was an overall prevalence of 45 per cent. Seropositivity ranged from 24-26 per cent in the 2-year-olds, up to 54 per cent in the 5-9-year-olds. There was no significant difference in prevalence between the se...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.5.234

    authors: Rawlins SC,Prabhakar P

    更新日期:1989-10-01 00:00:00