Abstract:
:During organogenesis, different cell types need to work together to generate functional multicellular structures. To study this process, we made use of the genetically tractable fly retina, with a focus on the mechanisms that coordinate morphogenesis between the different epithelial cell types that make up the optical lens. Our work shows that these epithelial cells present contractile apical-medial MyosinII meshworks, which control the apical area and junctional geometry of these cells during lens development. Our study also suggests that these MyosinII meshworks drive cell shape changes in response to external forces, and thus they mediate part of the biomechanical coupling that takes place between these cells. Importantly, our work, including mathematical modeling of forces and material stiffness during lens development, raises the possibility that increased cell stiffness acts as a mechanism for limiting this mechanical coupling. We propose this might be required in complex tissues, where different cell types undergo concurrent morphogenesis and where averaging out of forces across cells could compromise individual cell apical geometry and thereby organ function.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Blackie L,Walther RF,Staddon MF,Banerjee S,Pichaud Fdoi
10.1091/mbc.E19-09-0523subject
Has Abstractpub_date
2020-06-15 00:00:00pages
1355-1369issue
13eissn
1059-1524issn
1939-4586journal_volume
31pub_type
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