Getting insight into the pan-genome structure with PangTree.

Abstract:

BACKGROUND:The term pan-genome was proposed to denominate collections of genomic sequences jointly analyzed or used as a reference. The constant growth of genomic data intensifies development of data structures and algorithms to investigate pan-genomes efficiently. RESULTS:This work focuses on providing a tool for discovering and visualizing the relationships between the sequences constituting a pan-genome. A new structure to represent such relationships - called affinity tree - is proposed. Each node of this tree has assigned a subset of genomes, as well as their homogeneity level and averaged consensus sequence. Moreover, subsets assigned to sibling nodes form a partition of the genomes assigned to their parent. CONCLUSIONS:Functionality of affinity tree is demonstrated on simulated data and on the Ebola virus pan-genome. Furthermore, two software packages are provided: PangTreeBuild constructs affinity tree, while PangTreeVis presents its result.

journal_name

BMC Genomics

journal_title

BMC genomics

authors

Dziadkiewicz P,Dojer N

doi

10.1186/s12864-020-6610-4

subject

Has Abstract

pub_date

2020-04-16 00:00:00

pages

274

issue

Suppl 2

issn

1471-2164

pii

10.1186/s12864-020-6610-4

journal_volume

21

pub_type

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