解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:More accurate and complete reference genomes have improved understanding of gene function, biology, and evolutionary mechanisms. Hybrid genome assembly approaches leverage benefits of both long, relatively error-prone reads from third-generation sequencing technologies and short, accurate reads from second-g...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-021-07390-y
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Toxin-antitoxin (TA) systems, abundant in prokaryotes, are composed of a toxin gene and its cognate antitoxin. Several toxins are implied to affect the physiological state and stress tolerance of bacteria in a population. We previously identified a chromosomally encoded hok-sok type I TA system in Erwinia am...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-021-07376-w
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Avian infectious bronchitis virus (IBV) is a gamma coronavirus that severely affects the poultry industry worldwide. Long non-coding RNAs (lncRNAs), a subset of non-coding RNAs with a length of more than 200 nucleotides, have been recently recognized as pivotal factors in the pathogenesis of viral infections...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07359-3
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:Loaches of Cobitinae, widely distributed in Eurasian continent, have high economic, ornamental and scientific value. However, the phylogeny of Cobitinae fishes within genera or family level remains complex and controversial. Up to now, about 60 Cobitinae mitogenomes had been deposited in GenBank, but their i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07360-w
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Histone acetylation is a ubiquitous and reversible post-translational modification in eukaryotes and prokaryotes that is co-regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC). HAT activity is important for the modification of chromatin structure in eukaryotic cells, affecting gene tr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07348-6
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese native cattle breed, is reported to have originated from crossbreeding between taurine and indicine cattle; th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07340-0
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:Recently, pioneering expression quantitative trait loci (eQTL) studies on single cell RNA sequencing (scRNA-seq) data have revealed new and cell-specific regulatory single nucleotide variants (SNVs). Here, we present an alternative QTL-related approach applicable to transcribed SNV loci from scRNA-seq data: ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07334-y
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:Tomato plant growth is frequently hampered by a high susceptibility to pests and diseases. Traditional chemical control causes a serious impact on both the environment and human health. Therefore, seeking environment-friendly and cost-effective green methods in agricultural production becomes crucial nowaday...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07346-8
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:The pond snail Lymnaea stagnalis (L. stagnalis) has been widely used as a model organism in neurobiology, ecotoxicology, and parasitology due to the relative simplicity of its central nervous system (CNS). However, its usefulness is restricted by a limited availability of transcriptome data. While sequence i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07287-2
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Single-cell (sc) sequencing performs unbiased profiling of individual cells and enables evaluation of less prevalent cellular populations, often missed using bulk sequencing. However, the scale and the complexity of the sc datasets poses a great challenge in its utility and this problem is further exacerbate...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07300-8
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Genome-wide association studies (GWAS) have identified many individual genes associated with brain imaging quantitative traits (QTs) in Alzheimer's disease (AD). However single marker level association discovery may not be able to address the underlying biological interactions with disease mechanism. RESULT...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07282-7
更新日期:2020-12-29 00:00:00
abstract:BACKGROUND:Many transcripts have been generated due to the development of sequencing technologies, and lncRNA is an important type of transcript. Predicting lncRNAs from transcripts is a challenging and important task. Traditional experimental lncRNA prediction methods are time-consuming and labor-intensive. Efficient ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07237-y
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND:Ophiocordyceps sinensis is an important traditional Chinese medicine for its comprehensive active ingredients, such as cordycepin, cordycepic acid, and Cordyceps polysaccharide. O. sinensis zjut, a special strain isolated from O. sinensis, has similar pharmacological functions to wild O. sinensis. Currently,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07298-z
更新日期:2020-12-11 00:00:00
abstract:BACKGROUND:Whole mitogenomes or short fragments (i.e., 300-700 bp of the cox1 gene) are the markers of choice for revealing within- and among-species genealogies. Protocols for sequencing and assembling mitogenomes include 'primer walking' or 'long PCR' followed by Sanger sequencing or Illumina short-read low-coverage ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07292-5
更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Calcineurin B-like protein (CBL)-interacting protein kinases (CIPKs) are the primary components of calcium sensors, and play crucial roles in plant developmental processes, hormone signaling transduction, and in the response to exogenous stresses. RESULTS:In this study, 48 CIPK genes (SsCIPKs) were identifi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07264-9
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Cotton is an important fiber crop but has serious heterosis effects, and cytoplasmic male sterility (CMS) is the major cause of heterosis in plants. However, to the best of our knowledge, no studies have investigated CMS Yamian A in cotton with the genetic background of Australian wild Gossypium bickii. Conj...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07261-y
更新日期:2020-12-02 00:00:00
abstract:BACKGROUND:Ammonia is one of the most common toxicological environment factors affecting shrimp health. Although ammonia tolerance in shrimp is closely related to successful industrial production, few genetic studies of this trait are available. RESULTS:In this study, we constructed a high-density genetic map of the P...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07254-x
更新日期:2020-12-02 00:00:00
abstract:BACKGROUND:Distichiasis, an ocular disorder in which aberrant cilia (eyelashes) grow from the opening of the Meibomian glands of the eyelid, has been reported in Friesian horses. These misplaced cilia can cause discomfort, chronic keratitis, and corneal ulceration, potentially impacting vision due to corneal fibrosis, ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07265-8
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Copy number variations (CNVs) are a major form of genetic variations and are involved in animal domestication and genetic adaptation to local environments. We investigated CNVs in the domestic goat (Capra hircus) using Illumina short-read sequencing data, by comparing our lab data for 38 goats from three Chi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07267-6
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:The NBS disease-related gene family coordinates the inherent immune system in plants in response to pathogen infections. Previous studies have identified NBS-encoding genes in Pyrus bretschneideri ('Dangshansuli', an Asian pear) and Pyrus communis ('Bartlett', a European pear) genomes, but the patterns of ge...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07226-1
更新日期:2020-11-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC genomics
pub_type: 已发布勘误
doi:10.1186/s12864-020-07211-8
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Studying functional divergences between paralogs that originated from genome duplication is a significant topic in investigating molecular evolution. Genes that exhibit basal level cyclic expression patterns including circadian and light responsive genes are important physiological regulators. Temporal shift...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07202-9
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Lower eggshell quality in the late laying period leads to economic loss. It is a major threat to the quality and safety of egg products. Age-related variations in ultrastructure were thought to induce this deterioration. Eggshell formation is a highly complex process under precise regulation of genes and bio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07177-7
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND:Protein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum proteostasis, implicated in many diseases. The family prototype PDIA1 is also involved in vascular redox cell signaling. PDIA1 is coded by the P4HB gene. While forced chan...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07164-y
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:Unveiling fungal genome structure and function reveals the potential biotechnological use of fungi. Trichoderma harzianum is a powerful CAZyme-producing fungus. We studied the genomic regions in T. harzianum IOC3844 containing CAZyme genes, transcription factors and transporters. RESULTS:We used bioinformat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07158-w
更新日期:2020-11-02 00:00:00
abstract:BACKGROUND:Azadirachtin A is a triterpenoid from neem tree exhibiting excellent activities against over 600 insect species in agriculture. The production of azadirachtin A depends on extraction from neem tissues, which is not an eco-friendly and sustainable process. The low yield and discontinuous supply of azadirachti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07124-6
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina HumanMethylation450 BeadChip (450 K) which has now been replaced by the latest platform, Illumina Methylation...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07168-8
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Elucidating the candidate genes and key metabolites responsible for pulp and peel coloration is essential for breeding pitaya fruit with new and improved appeal and high nutritional value. Here, we used transcriptome (RNA-Seq) and metabolome analysis (UPLC-MS/MS) to identify structural and regulatory genes a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07133-5
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND:Sexual reproduction of scleractinians has captured the attention of researchers and the general public for decades. Although extensive ecological data has been acquired, underlying molecular and cellular mechanisms remain largely unknown. In this study, to better understand mechanisms underlying gametogenesi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07113-9
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Flammulina filiformis (previously known as Asian F. velutipes) is a popular commercial edible mushroom. Many bioactive compounds with medicinal effects, such as polysaccharides and sesquiterpenoids, have been isolated and identified from F. filiformis, but their biosynthesis and regulation at the molecular l...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07108-6
更新日期:2020-10-17 00:00:00
abstract:BACKGROUND:Homeobox-containing genes encode crucial transcription factors involved in animal, plant and fungal development, and changes to homeobox genes have been linked to the evolution of novel body plans and morphologies. In animals, some homeobox genes are clustered together in the genome, either as remnants from ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07027-6
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Belonging to lineage I of Brassicaceae, Camelina sativa is formed by two hybridizations of three species (three sub-genomes). The three sub-genomes were diverged from a common ancestor, likely derived from lineage I (Ancestral Crucifer karyotype, ACK). The karyotype evolutionary trajectories of the C. sativa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07081-0
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Common Pekin and Muscovy ducks and their intergeneric hinny and mule hybrids have different abilities for fatty liver production. RNA-Seq analyses from the liver of these different genetic types fed ad libitum or overfed would help to identify genes with different response to overfeeding between them. Howeve...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07099-4
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:The identification of cell type-specific genes (markers) is an essential step for the deconvolution of the cellular fractions, primarily, from the gene expression data of a bulk sample. However, the genes with significant changes identified by pair-wise comparisons cannot indeed represent the specificity of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06888-1
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the transcriptional regulation of the VLPO-Gal neurons in sleep by comparing their transcriptional responses between sleeping mice and those kept awake, sacrificed at ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07050-7
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Peromyscus are the most common mammalian species in North America and are widely used in both laboratory and field studies. The deer mouse, P. maniculatus and the old-field mouse, P. polionotus, are closely related and can generate viable and fertile hybrid offspring. The ability to generate hybrid offspring...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06969-1
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:According to history, in the pre-Hispanic period, during the conquest and Inka expansion in Ecuador, many Andean families of the Cañar region would have been displaced to several places of Tawantinsuyu, including Kañaris, a Quechua-speaking community located at the highlands of the Province of Ferreñafe, Lam...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06834-1
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:Precision medicine is a medical approach that takes into account individual genetic variability and often requires Next Generation Sequencing data in order to predict new treatments. Here we present GMIEC, Genomic Modules Identification et Characterization for genomics medicine, an application that is able t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06996-y
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:Aedes aegypti is the principle vector of many arboviruses, including dengue virus and Zika virus, which are transmitted when an infected female mosquito takes a blood meal in order to initiate vitellogenesis. During blood digestion, ~ 10 mM heme-iron is ingested into the midgut lumen. While heme acts as both...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06981-5
更新日期:2020-08-31 00:00:00
abstract:BACKGROUND:Antimicrobial resistance is one of our most serious health threats. Antimicrobial peptides (AMPs), effecter molecules of innate immune system, can defend host organisms against microbes and most have shown a lowered likelihood for bacteria to form resistance compared to many conventional drugs. Thus, AMPs ar...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06978-0
更新日期:2020-08-28 00:00:00