Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting.

abstract：BACKGROUND:Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that arsenic al...

journal_title：BMC genomics

authors： Posey T,Weng T,Chen Z,Chintagari NR,Wang P,Jin N,Stricker H,Liu L

更新日期：2008-03-03 00:00:00

abstract：BACKGROUND:Apple is an economically important fruit crop worldwide. Developing a genetic linkage map is a critical step towards mapping and cloning of genes responsible for important horticultural traits in apple. To facilitate linkage map construction, we surveyed and characterized the distribution and frequency of pe...

journal_title：BMC genomics

authors： Zhang Q,Ma B,Li H,Chang Y,Han Y,Li J,Wei G,Zhao S,Khan MA,Zhou Y,Gu C,Zhang X,Han Z,Korban SS,Li S,Han Y

更新日期：2012-10-07 00:00:00

abstract：BACKGROUND:There is an increasing interest in berries, especially blackberries in the diet, because of recent reports of their health benefits due to their high content of flavonoids. A broad range of genomic tools are available for other Rosaceae species but these tools are still lacking in the Rubus genus, thus limit...

journal_title：BMC genomics

authors： Garcia-Seco D,Zhang Y,Gutierrez-Mañero FJ,Martin C,Ramos-Solano B

更新日期：2015-01-22 00:00:00

abstract：BACKGROUND:DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between...

journal_title：BMC genomics

authors： Sharifi-Zarchi A,Gerovska D,Adachi K,Totonchi M,Pezeshk H,Taft RJ,Schöler HR,Chitsaz H,Sadeghi M,Baharvand H,Araúzo-Bravo MJ

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:It is widely known that castration has a significant effect on the accumulation of adipose tissue. microRNAs (miRNAs) are known to be involved in fat deposition and to be regulated by the androgen-induced androgen receptor (AR). However, there is little understanding of the relationship between miRNAs and fa...

journal_title：BMC genomics

authors： Bai Y,Huang JM,Liu G,Zhang JB,Wang JY,Liu CK,Fang MY

更新日期：2014-01-20 00:00:00

abstract：BACKGROUND:Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G protein-coupled receptors to stimulate the proliferation, migration and survival of many cell types. LPA signaling has been implicated in development, wound healing and cancer. While LPA signaling pathways have been studied extensiv...

journal_title：BMC genomics

authors： Stortelers C,Kerkhoven R,Moolenaar WH

更新日期：2008-08-14 00:00:00

abstract：BACKGROUND:Atlantic cod (Gadus morhua), is known to vary genetically across the North Atlantic, Greenland, and Newfoundland. This genetic variation occurs both spatially and temporally through decades of heavy fishing, and is concentrated in three linkage disequilibrium blocks, previously defined by pedigreed linkage m...

journal_title：BMC genomics

authors： Barney BT,Munkholm C,Walt DR,Palumbi SR

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequenc...

journal_title：BMC genomics

authors： Shah N,Gaupp R,Moriyama H,Eskridge KM,Moriyama EN,Somerville GA

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Due to the limited availability and high cost of fish oil in the face of increasing aquaculture production, there is a need to reduce usage of fish oil in aquafeeds without compromising farm fish health. Therefore, the present study was conducted to determine if different levels of vegetable and fish oils ca...

journal_title：BMC genomics

authors： Eslamloo K,Xue X,Hall JR,Smith NC,Caballero-Solares A,Parrish CC,Taylor RG,Rise ML

更新日期：2017-09-08 00:00:00

abstract：BACKGROUND:Phenylalanine ammonia lyase (PAL) is a key enzyme of the phenylpropanoid pathway that catalyzes the deamination of phenylalanine to trans-cinnamic acid, a precursor for the lignin and flavonoid biosynthetic pathways. To date, PAL genes have been less extensively studied in gymnosperms than in angiosperms. Ou...

journal_title：BMC genomics

authors： Bagal UR,Leebens-Mack JH,Lorenz WW,Dean JF

更新日期：2012-06-11 00:00:00

abstract：BACKGROUND:Little is known about the genome sequences of Euphausiacea (krill) although these crustaceans are abundant components of the pelagic ecosystems in all oceans and used for aquaculture and pharmaceutical industry. This study reports the results of an expressed sequence tag (EST) sequencing project from differe...

journal_title：BMC genomics

authors： De Pittà C,Bertolucci C,Mazzotta GM,Bernante F,Rizzo G,De Nardi B,Pallavicini A,Lanfranchi G,Costa R

更新日期：2008-01-28 00:00:00

abstract：BACKGROUND:Identification and classification of highly similar microbial strains is a challenging issue in microbiology, ecology and evolutionary biology. Among various available approaches, gene content analysis is also at the core of microbial taxonomy. However, no threshold has been determined for grouping microorgn...

journal_title：BMC genomics

authors： Tu Q,Lin L

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Bacterial invasive infection and host immune response is fundamental to the understanding of pathogen pathogenesis and the discovery of effective therapeutic drugs. However, there are very few experimental studies on the signaling cross-talks between bacteria and human host to date. METHODS:In this work, ta...

journal_title：BMC genomics

authors： Mei S,Flemington EK,Zhang K

更新日期：2018-06-28 00:00:00

abstract：BACKGROUND:The freshwater planarian Schmidtea mediterranea is recognised as a valuable model for research into adult stem cells and regeneration. With the advent of the high-throughput sequencing technologies, it has become feasible to undertake detailed transcriptional analysis of its unique stem cell population, the ...

journal_title：BMC genomics

authors： Rodríguez-Esteban G,González-Sastre A,Rojo-Laguna JI,Saló E,Abril JF

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Ecological studies routinely show genotype-genotype interactions between insects and their parasites. The mechanisms behind these interactions are not clearly understood. Using the bumblebee Bombus terrestris/trypanosome Crithidia bombi model system (two bumblebee colonies by two Crithidia strains), we have ...

journal_title：BMC genomics

authors： Riddell CE,Lobaton Garces JD,Adams S,Barribeau SM,Twell D,Mallon EB

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Controlling and managing the breeding of bluefin tuna (Thunnus spp.) in captivity is an imperative step towards obtaining a sustainable supply of these fish in aquaculture production systems. Germ cell transplantation (GCT) is an innovative technology for the production of inter-species surrogates, by transp...

journal_title：BMC genomics

authors： Bar I,Cummins S,Elizur A

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AM...

journal_title：BMC genomics

authors： Gandemer V,Rio AG,de Tayrac M,Sibut V,Mottier S,Ly Sunnaram B,Henry C,Monnier A,Berthou C,Le Gall E,Le Treut A,Schmitt C,Le Gall JY,Mosser J,Galibert MD

更新日期：2007-10-23 00:00:00

abstract：BACKGROUND:Expression profiling has been proposed as a means for screening non-model organisms in their natural environments to identify genes potentially important in adaptive diversification. Tag profiling using high throughput sequencing is a relatively low cost means of expression profiling with deep coverage. Howe...

journal_title：BMC genomics

authors： Voelckel C,Gruenheit N,Biggs P,Deusch O,Lockhart P

更新日期：2012-07-19 00:00:00

abstract：BACKGROUND:Fluctuations in external salinity force eukaryotic cells to respond by changes in the gene expression of proteins acting in protective biochemical processes, thus counteracting the changing osmotic pressure. The high-osmolarity glycerol (HOG) signaling pathway is essential for the efficient up-regulation of ...

journal_title：BMC genomics

authors： Vaupotic T,Plemenitas A

更新日期：2007-08-16 00:00:00

abstract：BACKGROUND:Whole-exome sequencing (WES) is rapidly evolving into a tool of choice for rapid, and inexpensive identification of molecular genetic lesions within targeted regions of the human genome. While biases in WES coverage of nucleotides in targeted regions are recognized, it is not well understood how repetition o...

journal_title：BMC genomics

authors： Cherukuri PF,Maduro V,Fuentes-Fajardo KV,Lam K,NISC Comparative Sequencing Program.,Adams DR,Tifft CJ,Mullikin JC,Gahl WA,Boerkoel CF

更新日期：2015-11-25 00:00:00

abstract：MOTIVATION:Mass spectrometry is a complex technique used for large-scale protein profiling with clinical and pharmaceutical applications. While individual components in the system have been studied extensively, little work has been done to integrate various modules and evaluate them from a systems point of view. RESUL...

journal_title：BMC genomics

authors： Sun Y,Braga-Neto U,Dougherty ER

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:Little is known, either experimentally or computationally, about the genomic sequence features that regulate malaria genes. A sequence conservation analysis of the malaria species P. falciparum, P. berghei, P. yoelii, and P. chabaudi could significantly advance knowledge of malaria gene regulation. RESULTS:...

journal_title：BMC genomics

authors： Imamura H,Persampieri JH,Chuang JH

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression implicated in multiple cellular processes. Cyclic stretch of alveoli is characteristic of mechanical ventilation, and is postulated to be partly responsible for the lung injury and inflammation in ventilator-induced lung injury. We pro...

journal_title：BMC genomics

authors： Yehya N,Yerrapureddy A,Tobias J,Margulies SS

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:Glandular trichomes produce a wide variety of commercially important secondary metabolites in many plant species. The most prominent anti-malarial drug artemisinin, a sesquiterpene lactone, is produced in glandular trichomes of Artemisia annua. However, only limited genomic information is currently available...

journal_title：BMC genomics

authors： Wang W,Wang Y,Zhang Q,Qi Y,Guo D

更新日期：2009-10-09 00:00:00

abstract：BACKGROUND:Electron microscopy analyses of replicating chloroplast molecules earlier predicted bidirectional Cairns replication as the prevalent mechanism, perhaps followed by rounds of a rolling circle mechanism. This standard model is being challenged by the recent proposition of homologous recombination-mediated rep...

journal_title：BMC genomics

authors： Krishnan NM,Rao BJ

更新日期：2009-05-20 00:00:00

abstract：BACKGROUND:Insect mitochondrial genomes (mitogenomes) are the most extensively used genetic marker for evolutionary and population genetics studies of insects. The Pentatomoidea superfamily is economically important and the largest superfamily within Pentatomomorpha with over 7,000 species. To better understand the div...

journal_title：BMC genomics

authors： Yuan ML,Zhang QL,Guo ZL,Wang J,Shen YY

更新日期：2015-06-16 00:00:00

abstract：BACKGROUND:Decapods are an order of crustaceans which includes shrimps, crabs, lobsters and crayfish. They occur worldwide and are of great scientific interest as well as being of ecological and economic importance in fisheries and aquaculture. However, our knowledge of their biology mainly comes from the group which i...

journal_title：BMC genomics

authors： Nong W,Chai ZYH,Jiang X,Qin J,Ma KY,Chan KM,Chan TF,Chow BKC,Kwan HS,Wong CKC,Qiu JW,Hui JHL,Chu KH

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Aspartic proteases are known to play an important role in the biology of nematode parasitism. This role is best characterised in blood-feeding nematodes, where they digest haemoglobin, but they are also likely to play important roles in the biology of nematode parasites that do not feed on blood. In the pres...

journal_title：BMC genomics

authors： Mello LV,O'Meara H,Rigden DJ,Paterson S

更新日期：2009-12-16 00:00:00

abstract：BACKGROUND:Duplication, followed by fixation or random loss of novel genes, contributes to genome evolution. Particular outcomes of duplication events are possibly associated with pathogenic life histories in fungi. To date, differential gene gain and loss have not been studied at genomic scales in fungal pathogens, de...

journal_title：BMC genomics

authors： Powell AJ,Conant GC,Brown DE,Carbone I,Dean RA

更新日期：2008-03-28 00:00:00

abstract：BACKGROUND:Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated by 1 to 5 bp (DR1-DR5). Although many known such response elements ...

journal_title：BMC genomics

authors： Laperriere D,Wang TT,White JH,Mader S

更新日期：2007-01-19 00:00:00