Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing.

abstract：BACKGROUND:Genomic imprinting is an evolutionary conserved mechanism of epigenetic gene regulation in placental mammals that results in silencing of one of the parental alleles. In order to decipher interactions between allele-specific DNA methylation of imprinted genes and evolutionary conservation, we performed a gen...

journal_title：BMC genomics

authors： Hutter B,Bieg M,Helms V,Paulsen M

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Following the association of Cronobacter spp. to several publicized fatal outbreaks in neonatal intensive care units of meningitis and necrotising enterocolitis, the World Health Organization (WHO) in 2004 requested the establishment of a molecular typing scheme to enable the international control of the org...

journal_title：BMC genomics

authors： Forsythe SJ,Dickins B,Jolley KA

更新日期：2014-12-16 00:00:00

abstract：BACKGROUND:GLV-1h68 is an attenuated recombinant vaccinia virus (VACV) that selectively colonizes established human xenografts inducing their complete regression. RESULTS:Here, we explored xenograft/VACV/host interactions in vivo adopting organism-specific expression arrays and tumor cell/VACV in vitro comparing VACV ...

journal_title：BMC genomics

authors： Worschech A,Chen N,Yu YA,Zhang Q,Pos Z,Weibel S,Raab V,Sabatino M,Monaco A,Liu H,Monsurró V,Buller RM,Stroncek DF,Wang E,Szalay AA,Marincola FM

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:Whole-exome sequencing (WES) is rapidly evolving into a tool of choice for rapid, and inexpensive identification of molecular genetic lesions within targeted regions of the human genome. While biases in WES coverage of nucleotides in targeted regions are recognized, it is not well understood how repetition o...

journal_title：BMC genomics

authors： Cherukuri PF,Maduro V,Fuentes-Fajardo KV,Lam K,NISC Comparative Sequencing Program.,Adams DR,Tifft CJ,Mullikin JC,Gahl WA,Boerkoel CF

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Mouse has served as an excellent model for studying human development and diseases due to its similarity to human. Advances in transgenic and knockout studies in mouse have dramatically strengthened the use of this model and significantly improved our understanding of gene function during development in the ...

journal_title：BMC genomics

authors： Xue L,Cai JY,Ma J,Huang Z,Guo MX,Fu LZ,Shi YB,Li WX

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:An important subfamily of membrane proteins are the transmembrane alpha-helical proteins, in which the membrane-spanning regions are made up of alpha-helices. Given the obvious biological and medical significance of these proteins, it is of tremendous practical importance to identify the location of transmem...

journal_title：BMC genomics

authors： Yang JY,Yang MQ,Dunker AK,Deng Y,Huang X

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The desiccation-tolerant moss Bryum argenteum is an important component of the Biological Soil Crusts (BSCs) found in the Gurbantunggut desert. Desiccation tolerance is defined as the ability to revive from the air dried state. To elucidate the molecular mechanisms related to desiccation tolerance, we employ...

journal_title：BMC genomics

authors： Gao B,Zhang D,Li X,Yang H,Zhang Y,Wood AJ

更新日期：2015-05-28 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) exist pervasively across viruses, plants and animals and play important roles in the post-transcriptional regulation of genes. In the common carp, miRNA targets have not been investigated. In model species, single-nucleotide polymorphisms (SNPs) have been reported to impair or enhance miRN...

journal_title：BMC genomics

authors： Zhu YP,Xue W,Wang JT,Wan YM,Wang SL,Xu P,Zhang Y,Li JT,Sun XW

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide...

journal_title：BMC genomics

authors： Apolis L,Olivas J,Srinivasan P,Kushwaha AK,Desai SA

更新日期：2019-01-16 00:00:00

abstract：BACKGROUND:Many gram-negative bacteria use type III secretion systems (T3SSs) to translocate effector proteins into host cells. T3SS effectors can give some bacteria a competitive edge over others within the same environment and can help bacteria to invade the host cells and allow them to multiply rapidly within the ho...

journal_title：BMC genomics

authors： Hobbs CK,Porter VL,Stow ML,Siame BA,Tsang HH,Leung KY

更新日期：2016-12-19 00:00:00

abstract：BACKGROUND:Genome-scale pooled CRISPR screens are powerful tools for identifying genetic dependencies across varied cellular processes. The vast majority of CRISPR screens reported to date have focused exclusively on the perturbation of protein-coding gene function. However, protein-coding genes comprise < 2% of the se...

journal_title：BMC genomics

authors： Borys SM,Younger ST

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:The Gram-negative bacterium Chlamydia pneumoniae (Cpn) is the leading intracellular human pathogen responsible for respiratory infections such as pneumonia and bronchitis. Basic and applied research in pathogen biology, especially the elaboration of new mechanism-based anti-pathogen strategies, target discov...

journal_title：BMC genomics

authors： Maier CJ,Maier RH,Virok DP,Maass M,Hintner H,Bauer JW,Onder K

更新日期：2012-11-16 00:00:00

abstract：BACKGROUND:Controlling gene expression is fundamental to biological complexity. The nematode Caenorhabditis elegans is an important model for studying principles of gene regulation in multi-cellular organisms. A comprehensive parts list of putative regulatory motifs was yet missing for this model system. In this study,...

journal_title：BMC genomics

authors： Dieterich C,Sommer RJ

更新日期：2008-01-23 00:00:00

abstract：BACKGROUND:The study and analysis of gene expression measurements is the primary focus of functional genomics. Once expression data is available, biologists are faced with the task of extracting (new) knowledge associated to the underlying biological phenomenon. Most often, in order to perform this task, biologists exe...

journal_title：BMC genomics

authors： Miyazaki FA,Guardia GD,Vêncio RZ,de Farias CR

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Pyrethroid resistance in Anopheles funestus populations has led to an increase in malaria transmission in southern Africa. Resistance has been attributed to elevated activities of cytochrome P450s but the molecular basis underlying this metabolic resistance is unknown. Microsatellite and SNP markers were use...

journal_title：BMC genomics

authors： Wondji CS,Morgan J,Coetzee M,Hunt RH,Steen K,Black WC 4th,Hemingway J,Ranson H

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:Single Nucleotide Polymorphisms (SNPs) can be used as genetic markers for applications such as genetic diversity studies or genetic mapping. New technologies now allow genotyping hundreds to thousands of SNPs in a single reaction.In order to evaluate the potential of these technologies in pea, we selected a ...

journal_title：BMC genomics

authors： Deulvot C,Charrel H,Marty A,Jacquin F,Donnadieu C,Lejeune-Hénaut I,Burstin J,Aubert G

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Fungal plant pathogens belonging to the genus Venturia cause damaging scab diseases of members of the Rosaceae. In terms of economic impact, the most important of these are V. inaequalis, which infects apple, and V. pirina, which is a pathogen of European pear. Given that Venturia fungi colonise the sub-cuti...

journal_title：BMC genomics

authors： Deng CH,Plummer KM,Jones DAB,Mesarich CH,Shiller J,Taranto AP,Robinson AJ,Kastner P,Hall NE,Templeton MD,Bowen JK

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Photorhabdus luminescens is an enteric bacterium, which lives in mutualistic association with soil nematodes and is highly pathogenic for a broad spectrum of insects. A complete genome sequence for the type strain P. luminescens subsp. laumondii TT01, which was originally isolated in Trinidad and Tobago, has...

journal_title：BMC genomics

authors： Zamora-Lagos MA,Eckstein S,Langer A,Gazanis A,Pfeiffer F,Habermann B,Heermann R

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:About 6 million Americans suffer from heart failure and 70% of heart failure cases are caused by myocardial infarction (MI). Following myocardial infarction, increased cytokines induce two major types of macrophages: classically activated macrophages which contribute to extracellular matrix destruction and a...

journal_title：BMC genomics

authors： Wang Y,Yang T,Ma Y,Halade GV,Zhang J,Lindsey ML,Jin YF

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:With advances in next generation sequencing technology and analysis methods, single nucleotide variants (SNVs) and indels can be detected with high sensitivity and specificity in exome sequencing data. Recent studies have demonstrated the ability to detect disease-causing copy number variants (CNVs) in exome...

journal_title：BMC genomics

authors： Samarakoon PS,Sorte HS,Stray-Pedersen A,Rødningen OK,Rognes T,Lyle R

更新日期：2016-01-14 00:00:00

abstract：BACKGROUND:Ecological studies routinely show genotype-genotype interactions between insects and their parasites. The mechanisms behind these interactions are not clearly understood. Using the bumblebee Bombus terrestris/trypanosome Crithidia bombi model system (two bumblebee colonies by two Crithidia strains), we have ...

journal_title：BMC genomics

authors： Riddell CE,Lobaton Garces JD,Adams S,Barribeau SM,Twell D,Mallon EB

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Although numerous investigations have compared gene expression microarray platforms, preprocessing methods and batch correction algorithms using constructed spike-in or dilution datasets, there remains a paucity of studies examining the properties of microarray data using diverse biological samples. Most mic...

journal_title：BMC genomics

authors： Richard AC,Lyons PA,Peters JE,Biasci D,Flint SM,Lee JC,McKinney EF,Siegel RM,Smith KG

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:About 10% of cases of male infertility are due to the presence of microdeletions within the long arm of the Y chromosome (Yq). Despite the large literature covering this critical issue, very little is known about the pathogenic mechanism leading to spermatogenesis disruption in patients carrying these microd...

journal_title：BMC genomics

authors： Gatta V,Raicu F,Ferlin A,Antonucci I,Scioletti AP,Garolla A,Palka G,Foresta C,Stuppia L

更新日期：2010-06-24 00:00:00

abstract：BACKGROUND:Gibel carp is an important aquaculture species in China, and a herpesvirus, called as Carassius auratus herpesvirus (CaHV), has hampered the aquaculture development. Diverse gynogenetic clones of gibel carp have been identified or created, and some of them have been used as aquaculture varieties, but their r...

journal_title：BMC genomics

authors： Gao FX,Wang Y,Zhang QY,Mou CY,Li Z,Deng YS,Zhou L,Gui JF

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Using a combination of pyrosequencing and conventional Sanger sequencing, the complete genome sequence of the recently described novel Brucella species, Brucella microti, was determined. B. microti is a member of the genus Brucella within the Alphaproteobacteria, which consists of medically important highly ...

journal_title：BMC genomics

authors： Audic S,Lescot M,Claverie JM,Scholz HC

更新日期：2009-08-04 00:00:00

abstract：BACKGROUND:The genome of the carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii, Order: Dasyuromorphia), was sequenced in the hopes of finding a cure for or gaining a better understanding of the contagious devil facial tumor disease that is threatening the species' survival. To better understand the Tasma...

journal_title：BMC genomics

authors： Nilsson MA,Janke A,Murchison EP,Ning Z,Hallström BM

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Single-cell (sc) sequencing performs unbiased profiling of individual cells and enables evaluation of less prevalent cellular populations, often missed using bulk sequencing. However, the scale and the complexity of the sc datasets poses a great challenge in its utility and this problem is further exacerbate...

journal_title：BMC genomics

authors： Kumar N,Golhar R,Sharma KS,Holloway JL,Sarangi S,Neuhaus I,Walsh AM,Pitluk ZW

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Litter size in pigs is a major factor affecting the profitability in the pig industry. The peri-implantation window in pigs is characterized by the coordinated interactions between the maternal uterine endometrium and the rapidly elongating conceptuses and represents a period of time during which a large per...

journal_title：BMC genomics

authors： Gu T,Zhu MJ,Schroyen M,Qu L,Nettleton D,Kuhar D,Lunney JK,Ross JW,Zhao SH,Tuggle CK

更新日期：2014-02-24 00:00:00

abstract：BACKGROUND:Protein effectors of pathogenicity are instrumental in modulating host immunity and disease resistance. The powdery mildew pathogen of grasses Blumeria graminis causes one of the most important diseases of cereal crops. B. graminis is an obligate biotrophic pathogen and as such has an absolute requirement to...

journal_title：BMC genomics

authors： Pedersen C,Ver Loren van Themaat E,McGuffin LJ,Abbott JC,Burgis TA,Barton G,Bindschedler LV,Lu X,Maekawa T,Wessling R,Cramer R,Thordal-Christensen H,Panstruga R,Spanu PD

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:The overwhelming amount of network data in functional genomics is making its visualization cluttered with jumbling nodes and edges. Such cluttered network visualization, which is known as "hair-balls", is significantly hindering data interpretation and analysis of researchers. Effective navigation approaches...

journal_title：BMC genomics

authors： Praneenararat T,Takagi T,Iwasaki W

更新日期：2012-01-01 00:00:00