Contrasting genetic variation and positive selection followed the divergence of NBS-encoding genes in Asian and European pears.

abstract：BACKGROUND:The emergence of epithelia was the foundation of metazoan expansion. Epithelial tissues are a hallmark of metazoans deeply rooted in the evolution of their complex developmental morphogenesis processes. However, studies on the epithelial features of non-bilaterians are still sparse and it remains unclear whe...

journal_title：BMC genomics

authors： Belahbib H,Renard E,Santini S,Jourda C,Claverie JM,Borchiellini C,Le Bivic A

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Mitochondria are organelles that fulfill a fundamental role in cell bioenergetics, as well as in other processes like cell signaling and death. Small non-coding RNAs (sncRNA) are now being considered as pivotal post-transcriptional regulators, widening the landscape of their diversity and functions. In mamma...

journal_title：BMC genomics

authors： Larriba E,Rial E,Del Mazo J

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:RNA-Seq is now widely used as a research tool. Choices must be made whether to use paired-end (PE) or single-end (SE) sequencing, and whether to use strand-specific or non-specific (NS) library preparation kits. To date there has been no analysis of the effect of these choices on identifying differentially e...

journal_title：BMC genomics

authors： Corley SM,MacKenzie KL,Beverdam A,Roddam LF,Wilkins MR

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins. HSP90 proteins have been found in a variety of organisms suggesting that they are ancient and conserved. In this study we investigate ...

journal_title：BMC genomics

authors： Chen B,Zhong D,Monteiro A

更新日期：2006-06-17 00:00:00

abstract：BACKGROUND:In many microbial genomes, a strong preference for a small number of codons can be observed in genes whose products are needed by the cell in large quantities. This codon usage bias (CUB) improves translational accuracy and speed and is one of several factors optimizing cell growth. Whereas CUB and the overr...

journal_title：BMC genomics

authors： von Mandach C,Merkl R

更新日期：2010-11-04 00:00:00

abstract：BACKGROUND:Effective bioinformatics solutions are needed to tackle challenges posed by industrial-scale genome annotation. We present Bcheck, a wrapper tool which predicts RNase P RNA genes by combining the speed of pattern matching and sensitivity of covariance models. The core of Bcheck is a library of subfamily spec...

journal_title：BMC genomics

authors： Yusuf D,Marz M,Stadler PF,Hofacker IL

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Human interfollicular epidermis is sustained by the proliferation of stem cells and their progeny, transient amplifying cells. Molecular characterization of these two cell populations is essential for better understanding of self renewal, differentiation and mechanisms of skin pathogenesis. The purpose of th...

journal_title：BMC genomics

authors： Koçer SS,Djurić PM,Bugallo MF,Simon SR,Matic M

更新日期：2008-07-30 00:00:00

abstract：BACKGROUND:Laminitis, the structural failure of interdigitated tissue that suspends the distal skeleton within the hoof capsule, is a devastating disease that is the second leading cause of both lameness and euthanasia in the horse. Current transcriptomic research focuses on the expression of known genes. However, as t...

journal_title：BMC genomics

authors： Holl HM,Gao S,Fei Z,Andrews C,Brooks SA

更新日期：2015-10-03 00:00:00

abstract：BACKGROUND:To understand gene expression networks leading to functional properties of the soybean seed, we have undertaken a detailed examination of soybean seed development during the stages of major accumulation of oils, proteins, and starches, as well as the desiccating and mature stages, using microarrays consistin...

journal_title：BMC genomics

authors： Jones SI,Gonzalez DO,Vodkin LO

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:Salmonella enterica is a significant foodborne pathogen, which can be transmitted via several distinct routes, and reports on acquisition of antimicrobial resistance (AMR) are increasing. To better understand the association between human Salmonella clinical isolates and the potential environmental/animal re...

journal_title：BMC genomics

authors： Pornsukarom S,van Vliet AHM,Thakur S

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Emerging evidence has been experimentally confirmed the tissue-specific expression of circRNAs (circRNAs). Global identification of human tissue-specific circRNAs is crucial for the functionality study, which facilitates the discovery of circRNAs for potential diagnostic biomarkers. RESULTS:In this study, c...

journal_title：BMC genomics

authors： Liu YC,Chiu YJ,Li JR,Sun CH,Liu CC,Huang HD

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:Tandem repeats are ubiquitous and abundant in higher eukaryotic genomes and constitute, along with transposable elements, much of DNA underlying centromeres and other heterochromatic domains. In maize, centromeric satellite repeat (CentC) and centromeric retrotransposons (CR), a class of Ty3/gypsy retrotrans...

journal_title：BMC genomics

authors： Sharma A,Wolfgruber TK,Presting GG

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) exist pervasively across viruses, plants and animals and play important roles in the post-transcriptional regulation of genes. In the common carp, miRNA targets have not been investigated. In model species, single-nucleotide polymorphisms (SNPs) have been reported to impair or enhance miRN...

journal_title：BMC genomics

authors： Zhu YP,Xue W,Wang JT,Wan YM,Wang SL,Xu P,Zhang Y,Li JT,Sun XW

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Nitrogen (N) is a key macronutrient required for plant growth and development. In this study, watermelon plants were grown under hydroponic conditions at 0.2 mM N, 4.5 mM N, and 9 mM N for 14 days. RESULTS:Dry weight and photosynthetic assimilation at low N (0.2 mM) was reduced by 29 and 74% compared with h...

journal_title：BMC genomics

authors： Nawaz MA,Chen C,Shireen F,Zheng Z,Sohail H,Afzal M,Ali MA,Bie Z,Huang Y

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:The laying hen model of spontaneous epithelial ovarian cancer (EOC) is unique in that it is the only model that enables observations of early events in disease progression and is therefore also uniquely suited for chemoprevention trials. Previous studies on the effect of dietary flaxseed in laying hens have ...

journal_title：BMC genomics

authors： Hales KH,Speckman SC,Kurrey NK,Hales DB

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:Improving fiber quality is a major challenge in cotton breeding, since the molecular basis of fiber quality traits is poorly understood. Fine mapping and candidate gene prediction of quantitative trait loci (QTL) controlling cotton fiber quality traits can help to elucidate the molecular basis of fiber quali...

journal_title：BMC genomics

authors： Liu D,Zhang J,Liu X,Wang W,Liu D,Teng Z,Fang X,Tan Z,Tang S,Yang J,Zhong J,Zhang Z

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following...

journal_title：BMC genomics

authors： Borghini L,Hibberd M,Davila S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:The establishment of C4 photosynthesis in maize is associated with differential accumulation of gene transcripts and proteins between bundle sheath and mesophyll photosynthetic cell types. We have physically separated photosynthetic cell types in the leaf blade to characterize differences in gene expression ...

journal_title：BMC genomics

authors： Sawers RJ,Liu P,Anufrikova K,Hwang JT,Brutnell TP

更新日期：2007-01-09 00:00:00

abstract：BACKGROUND:Genetic populations provide the basis for a wide range of genetic and genomic studies and have been widely used in genetic mapping, gene discovery and genomics-assisted breeding. Chromosome segment substitution lines (CSSLs) are the most powerful tools for the detection and precise mapping of quantitative tr...

journal_title：BMC genomics

authors： Xu J,Zhao Q,Du P,Xu C,Wang B,Feng Q,Liu Q,Tang S,Gu M,Han B,Liang G

更新日期：2010-11-24 00:00:00

abstract：BACKGROUND:The approaches for shotgun-based sequencing of vertebrate genomes are now well-established, and have resulted in the generation of numerous draft whole-genome sequence assemblies. In contrast, the process of refining those assemblies to improve contiguity and increase accuracy (known as 'sequence finishing')...

journal_title：BMC genomics

authors： Blakesley RW,Hansen NF,Gupta J,McDowell JC,Maskeri B,Barnabas BB,Brooks SY,Coleman H,Haghighi P,Ho SL,Schandler K,Stantripop S,Vogt JL,Thomas PJ,NISC Comparative Sequencing Program.,Bouffard GG,Green ED

更新日期：2010-01-11 00:00:00

abstract：BACKGROUND:Yellow-feathered chickens (YFCs) have a long history in China. They are well-known for the nutritional and commercial importance attributable to their yellow color phenotype. Currently, there is a huge paucity in knowledge of the genetic determinants responsible for phenotypic and biochemical properties of t...

journal_title：BMC genomics

authors： Huang X,Otecko NO,Peng M,Weng Z,Li W,Chen J,Zhong M,Zhong F,Jin S,Geng Z,Luo W,He D,Ma C,Han J,Ommeh SC,Zhang Y,Zhang X,Du B

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:Small RNAs (sRNAs) have emerged as important regulatory molecules and have been studied in several bacteria. However, to date, there have been no whole-transcriptome studies on sRNAs in any of the Soft Rot Enterobacteriaceae (SRE) group of pathogens. Although the main ecological niches for these pathogens ar...

journal_title：BMC genomics

authors： Kwenda S,Gorshkov V,Ramesh AM,Naidoo S,Rubagotti E,Birch PR,Moleleki LN

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:A fundamental requirement for genomic studies is the availability of genetic material of good quality and quantity. The desired quantity and quality are often hard to obtain when target DNA is composed of complex mixtures of relatively short DNA fragments. Here, we sought to develop a method to representativ...

journal_title：BMC genomics

authors： Shoaib M,Baconnais S,Mechold U,Le Cam E,Lipinski M,Ogryzko V

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend themselves against ROS/RNS, bacteria possess a subsystem of detoxification enzymes, which are classi...

journal_title：BMC genomics

authors： Thybert D,Avner S,Lucchetti-Miganeh C,Chéron A,Barloy-Hubler F

更新日期：2008-12-31 00:00:00

abstract：BACKGROUND:Transporter proteins are one of an organism's primary interfaces with the environment. The expressed set of transporters mediates cellular metabolic capabilities and influences signal transduction pathways and regulatory networks. The functional annotation of most transporters is currently limited to general...

journal_title：BMC genomics

authors： Giuliani SE,Frank AM,Corgliano DM,Seifert C,Hauser L,Collart FR

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:Ammopiptanthus mongolicus (Maxim. ex Kom.) Cheng f., an evergreen broadleaf legume shrub, is distributed in Mid-Asia where the temperature can be as low as -30°C during the winter. Although A. mongolicus is an ideal model to study the plant response to cold stress, insufficient genomic resources for this spe...

journal_title：BMC genomics

authors： Pang T,Ye CY,Xia X,Yin W

更新日期：2013-07-18 00:00:00

abstract：BACKGROUND:Subtractive hybridization methods are valuable tools for identifying differentially regulated genes in a given tissue avoiding redundant sequencing of clones representing the same expressed genes, maximizing detection of low abundant transcripts and thus, affecting the efficiency and cost effectiveness of sm...

journal_title：BMC genomics

authors： Fernández P,Paniego N,Lew S,Hopp HE,Heinz RA

更新日期：2003-09-30 00:00:00

abstract：BACKGROUND:Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates. RESULTS:To enable functional analysis of human transposase-derived genes, we comb...

journal_title：BMC genomics

authors： Henssen AG,Jiang E,Zhuang J,Pinello L,Socci ND,Koche R,Gonen M,Villasante CM,Armstrong SA,Bauer DE,Weng Z,Kentsis A

更新日期：2016-08-04 00:00:00

abstract：BACKGROUND:Macrosatellites are some of the largest variable number tandem repeats in the human genome, but what role these unusual sequences perform is unknown. Their importance to human health is clearly demonstrated by the 4q35 macrosatellite D4Z4 that is associated with the onset of the muscle degenerative disease f...

journal_title：BMC genomics

authors： Tremblay DC,Alexander G Jr,Moseley S,Chadwick BP

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND:Oil palm is the second largest source of edible oil which contributes to approximately 20% of the world's production of oils and fats. In order to understand the molecular biology involved in in vitro propagation, flowering, efficient utilization of nitrogen sources and root diseases, we have initiated an ex...

journal_title：BMC genomics

authors： Ho CL,Kwan YY,Choi MC,Tee SS,Ng WH,Lim KA,Lee YP,Ooi SE,Lee WW,Tee JM,Tan SH,Kulaveerasingam H,Alwee SS,Abdullah MO

更新日期：2007-10-22 00:00:00