Abstract:
:In recent years, studies have found that E2F1, a downstream effector of caveolin-1 (Cav-1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1-MFN2 axis as a regulator of mitophagy. Our data establish a new novel paradigm for regulation of the tumor cell metabolic reprogramming pathway by Cav-1 that is operationally linked and mutually dependent on the transcriptional activation of E2F1 and induces mitophagy with BNIP3 in cancer-associated fibroblasts (CAFs).
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Shen C,Chen X,Xiao K,Che Gdoi
10.1111/1759-7714.13408subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1369-1371issue
6eissn
1759-7706issn
1759-7714journal_volume
11pub_type
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