Abstract:
BACKGROUND:Esophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease-1 (FEN1) in esophageal squamous cell carcinoma ESCC. METHODS:Clinical blood samples of 629 ESCC cases and 686 control samples were collected. The ligation detection reaction method was used to determine FEN 1 rs174538 G>A genotypes. RESULTS:A significantly decreased risk of ESCC was associated with FEN1 rs174538 GA genotypes among patients under 63 years old. CONCLUSIONS:Our results suggest that functional polymorphism FEN1 rs174538 G>A might affect personal susceptibility to ESCC. This result provides a solid theoretical foundation for further clinical study using larger sample sizes.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Sang Y,Bo L,Gu H,Yang W,Chen Ydoi
10.1111/1759-7714.12422subject
Has Abstractpub_date
2017-05-01 00:00:00pages
192-196issue
3eissn
1759-7706issn
1759-7714journal_volume
8pub_type
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