Use of glucocorticoids in the management of immunotherapy-related adverse effects.

abstract：:A 78-year-old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground-glass opacities (GGOs) in both the lower lung lobes; drug-induced pneumonia was speculated. Eosinophil cou...

journal_title：Thoracic cancer

authors： Hara K,Yamasaki K,Tahara M,Kimuro R,Yamaguchi Y,Suzuki Y,Kawabata H,Kawanami T,Fujimoto N,Yatera K

更新日期：2021-01-21 00:00:00

abstract：:In patients with non-small cell lung cancer (NSCLC), stereotactic radiotherapy (SRT) is one of the standard therapies for those suffering with intracranial metastatic NSCLC. Radiation-induced necrosis (RIN) sometimes occurs as the result of the delayed effects of SRT. The magnetic resonance imaging (MRI) of RIN typica...

journal_title：Thoracic cancer

authors： Takamori S,Seto T,Jinnouchi M,Matsubara T,Haratake N,Miura N,Toyozawa R,Yamaguchi M,Takenoyama M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:This study aimed to compare survival between standard lobectomy and surgeons' preference sublobar resection among patients with stage I non-small cell lung cancer (NSCLC). METHODS:Medical records of patients undergoing pulmonary resection between 2006 and 2016 were reviewed retrospectively. Differences in d...

journal_title：Thoracic cancer

authors： Huang CS,Hsu PK,Chen CK,Yeh YC,Hsu HS,Shih CC,Huang BS

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Most non-small cell lung cancer (NSCLC) patients relapse on anaplastic lymphoma kinase-tyrosine kinase inhibitor (ALK-TKI) therapy because of acquired resistance. Rebiopsy is recommended to provide optimal therapy after relapse for some ALK-TKI therapies; however, little clinical data exists on the clinical ...

journal_title：Thoracic cancer

authors： Haratake N,Seto T,Takamori S,Toyozawa R,Nosaki K,Miura N,Ohba T,Toyokawa G,Taguchi K,Yamaguchi M,Shimokawa M,Takenoyama M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Accumulated evidence has revealed that the dysregulation of micro ribonucleic acids (miRNAs) may contribute to esophageal squamous cell carcinoma (ESCC). MiR-93, which is a member of the miRNA cluster miR-106b∼25, has been widely studied for its tumor promoting effect on different types of cancers. However, ...

journal_title：Thoracic cancer

authors： Li C,Ding C,Chen T,Chen J,Xu Z,Lei Z,Xu C,Zhao J

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:VATS pulmonary segmentectomy is increasingly proposed as a parenchyma-sparing resection for tumors smaller than 2 cm in diameter. The aim of this study was to compare short-term oncological results and local control in solid non-small cell lung cancers (NSCLCs) <2 cm surgically treated by intentional VATS ...

journal_title：Thoracic cancer

authors： Darras M,Ojanguren A,Forster C,Zellweger M,Perentes JY,Krueger T,Gonzalez M

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is an aggressive cancer refractory to current therapies. Reduced expression of micro ribonucleic acid (miR)-591 in a range of cancer types has suggested it is a potent tumor suppressor, and overexpression has been shown to inhibit tumor cell growth. The role of miR-591 in...

journal_title：Thoracic cancer

authors： Cheng S,Xu Y,Shi Z,Lin Y,Hoang CD,Zhang X

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Sphingosine 1-phosphate (S1P), a bioactive lipid, has been shown to mediate cancer processes. Therefore, accurate qualitative and quantitative determination is essential. The current assay method is still cumbersome to be of practical use worldwide and the aim of this study was therefore to develop a fast, a...

journal_title：Thoracic cancer

authors： Tang X,Chen H,Chen G,Duan C,Fan Q,Li H,Wang Y,Li Z,Shi W,Liu Y

更新日期：2020-06-01 00:00:00

abstract：:After sternal tumor resection, reconstruction of chest wall defects is still a challenging part of thoracic surgery. Three-dimensional (3D)-printed titanium alloy prosthesis implants provide an effective solution. The bionic bone trabecular micropore structure, which is beneficial to the human body, increases stabilit...

journal_title：Thoracic cancer

authors： Wang W,Liang Z,Yang S,Feng Q,Nie X,Su G,Yuan W,Han Y

更新日期：2020-11-01 00:00:00

abstract：:Pleomorphic adenoma is the most common type of salivary gland tumor. Although it rarely affects the trachea and bronchus, it usually grows in the airway and presents as an endobronchial mass. We recently experienced a case of pleomorphic adenoma originating in the bronchus and growing outward into the mediastinum. We ...

journal_title：Thoracic cancer

authors： Lee YK,Kim YH,Kim GY,Youn HC

更新日期：2014-01-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have been widely used in the management of malignant tumors. Programmed death 1 (PD-1)/PD-1 ligand (PD-L1) inhibitors have been introduced to treat non-small cell lung cancer (NSCLC) in recent years. Currently, PD-1/PD-L1 inhibitors are considered to have minor side effects and do n...

journal_title：Thoracic cancer

authors： Lu M,Zhang L,Li Y,Wang H,Guo X,Zhou J,Duan L,Si X,Xu Y,Zhang L

更新日期：2020-03-01 00:00:00

abstract：:Meningeal carcinomatosis (MC) refers to the diffuse or multifocal spread or infiltration of malignant tumors in the pia mater. It is a special distribution type of metastatic tumors in the central nervous system and one of the important reasons of death caused by metastatic malignant tumors. Here, we report a rare cas...

journal_title：Thoracic cancer

authors： Liu H,Liu L,Zhang X,Jin S

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the oncological prognosis and neurological outcomes for patients with thymic epithelial tumors (TETs) after thymectomy. METHODS:Consecutive patients with TETs who underwent thymectomy at Beijing Hospital from January 2011 to December 2018 were retrospectively enrolled into the study. Clinical, p...

journal_title：Thoracic cancer

authors： Tian W,Sun Y,Wu Q,Jiao P,Ma C,Yu H,Huang C,Tong H

更新日期：2020-07-01 00:00:00

abstract：:Several authors have previously reported that patients with pulmonary combined large cell neuroendocrine cancer ( LCNEC) have a poor prognosis and there is no consensus on the treatment strategy for combined LCNEC as well as LCNEC. Here, we report the case of a long-term survivor with pulmonary combined LCNEC. The pat...

journal_title：Thoracic cancer

authors： Oda R,Okuda K,Yamashita Y,Sakane T,Tatematsu T,Yokota K,Endo K,Nakanishi R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Scutellarin (SCU), a flavonoid isolated from Erigeron breviscapus (Vant.) Hand.-Mazz., increases autophagy and apoptosis in the adenocarcinoma A549 cell line, which is resistant to cisplatin. However, whether SCU alone has antitumor activity against non-small cell lung cancer (NSCLC) is unknown. METHODS:Cel...

journal_title：Thoracic cancer

authors： Cao P,Liu B,Du F,Li D,Wang Y,Yan X,Li X,Li Y

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the patterns and influencing factors of local-regional recurrence of lower thoracic esophageal squamous cell carcinoma (TESCC) after curative resection and to delineate the clinical target volume (CTV) of postoperative radiotherapy (PORT). METHODS:From January 2009 t...

journal_title：Thoracic cancer

authors： Liu J,Cai X,Liu Q,Li H,Cheng Y,Fu X

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance. Although CD73 overexpression has been reported to be a poor prognostic factor in several malignancies including non-small cell lung cancer (NSCLC), its predictiv...

journal_title：Thoracic cancer

authors： Ishii H,Azuma K,Kawahara A,Kinoshita T,Matsuo N,Naito Y,Tokito T,Yamada K,Akiba J,Hoshino T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is a major type of lung cancer with high morbidity and high mortality. miR-874 has been determined to play a role in tumor suppression in several cancers. The purpose of our study was to detect the biological mechanisms of miR-874 and AQP3 in NSCLC. METHODS:CCK-8 and Trans...

journal_title：Thoracic cancer

authors： Wang S,Wu Y,Yang S,Liu X,Lu Y,Liu F,Li G,Tian G

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Connective tissue disease increases the risk of lung cancer, but whether rheumatoid arthritis (RA) has an effect on the overall survival (OS) rate in this population has not been well studied. METHODS:Patients diagnosed with lung cancer between January 2015 and December 2017 were enrolled in this retrospect...

journal_title：Thoracic cancer

authors： Zhang L,Zhao Q,Yuan F,Liu M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the influence of image-guided tumor localization modality (Synchrony tracking vs. Xsight spine-based localization) on the local efficacy of CyberKnife treatment in lung cancer and lung metastases. METHODS:Retrospective analysis of 64 patients with pulmonary metastases an...

journal_title：Thoracic cancer

authors： Guo Y,Zhuang H,Zhao L,Yuan Z,Wang P

更新日期：2015-05-01 00:00:00

abstract：:Patients undergoing hemodialysis (HD) are frequently elderly with poor performance status and usually cannot withstand chemotherapy because of its toxicities. We report a case of an elderly woman with chronic renal failure undergoing HD who was diagnosed with advanced non-small cell lung cancer and treated with orally...

journal_title：Thoracic cancer

authors： Luo J,Ni L,Wang M,Zhong W,Xiao Y,Zheng K,Hu P

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Osimertinib (AZD9291) is a third-generation EGFR-tyrosine kinase inhibitor (TKI) that selectively inhibits the activating EGFR mutation and T790M mutation, and is currently used globally to treat EGFR-mutant non-small cell lung cancer (NSCLC). However, acquired resistance to osimertinib is inevitable. METHO...

journal_title：Thoracic cancer

authors： Hayakawa D,Takahashi F,Mitsuishi Y,Tajima K,Hidayat M,Winardi W,Ihara H,Kanamori K,Matsumoto N,Asao T,Ko R,Shukuya T,Takamochi K,Hayashi T,Suehara Y,Takeda Nakamura I,Ueno T,Kohsaka S,Mano H,Takahashi K

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The combination of EGFR tyrosine kinase inhibitors (TKIs) and chemotherapy is thought to increase treatment efficacy in non-small-cell lung cancer (NSCLC). This study investigated the efficacy and potential mechanisms of different combined modes of icotinib plus pemetrexed in EGFR-mutant lung adenocarcinoma ...

journal_title：Thoracic cancer

authors： Cui J,Zhang Y,Su D,Li T,Li Y

更新日期：2018-09-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The unique spectrum of immune-related adverse events (IrAEs) may occur during treatment. Dermatologic toxicities appear to be one of the most prevalent immunotherapy-related adverse events. The most common symptoms are maculopapular rash and pru...

journal_title：Thoracic cancer

authors： Si X,He C,Zhang L,Liu X,Li Y,Wang H,Guo X,Zhou J,Duan L,Wang M,Zhang L

更新日期：2020-02-01 00:00:00

abstract：:Tyrosine kinase inhibitors are used as first-line treatment for non-small cell lung cancer (NSCLC) patients harboring driver mutations in EGFR, ALK, ROS1, and BRAF. Currently, standard molecular testing approaches help identify single genes for such targetable driver mutations in NSCLC; however, next-generation sequen...

journal_title：Thoracic cancer

authors： Onozawa H,Saito H,Sunami K,Kubo T,Yamamoto N,Kasajima R,Ohtsu T,Hiroshima Y,Kanamori H,Yokose T,Miyagi Y

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Approximately 8.3-15.9% of patients with clinical stage I non-small cell lung cancer are subsequently shown to have lymph node metastasis. However, the clinical characteristics of patients with lymph node metastasis in China are not fully understood. METHODS:This is a multicenter retrospective analysis of p...

journal_title：Thoracic cancer

authors： Chen B,Wang X,Yu X,Xia WJ,Zhao H,Li XF,Liu LX,Liu Y,Hu J,Fu XN,Li Y,Xu YJ,Liu DR,Yang HY,Xu L,Jiang F

更新日期：2019-03-01 00:00:00

abstract：:The main recurrence pattern for lung cancer patients after radical surgery is distant metastasis. The probability of pancreatic metastasis in patients diagnosed with lung squamous cell carcinoma is 0.02%, with a poor prognosis. Chemotherapy is the preferred treatment for recurrence. Single lesions or oligometastasis c...

journal_title：Thoracic cancer

authors： Wang W,Huang C,Wu S,Liu Z,Liu L,Li L,Li S

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Breast cancer (BC) is a heterogeneous malignant tumor that threatens the health of women worldwide. Hsa_circRNA_0000518 (circ_0000518) has been revealed to be upregulated in BC tissues. However, the role and mechanism of circ_0000518 in BC are indistinct. METHODS:Quantitative real-time polymerase chain reac...

journal_title：Thoracic cancer

authors： Jiang J,Lin H,Shi S,Hong Y,Bai X,Cao X

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Esophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease-1 (FEN1) in esophageal squamous cell carcino...

journal_title：Thoracic cancer

authors： Sang Y,Bo L,Gu H,Yang W,Chen Y

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the characteristics of active anti-cancer treatment (AAT) compared with best supportive care (BSC) in elderly patients with advanced non-small cell lung cancer (NSCLC). METHODS:A retrospective analysis of 144 patients, aged 70 or older, with stage IIIb/IV NSCLC from 672 patients...

journal_title：Thoracic cancer

authors： Kim JH,Ryu MS,Ryu YJ,Lee JH,Shim SS,Kim Y,Chang JH

更新日期：2014-03-01 00:00:00