解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Few studies have been conducted on the relationship between chronic periodontitis and postoperative pneumonia (POP) in patients with lung and esophageal cancer. Furthermore, it remains controversial as to whether improving the periodontal condition of patients with lung and esophageal cancer before surgery r...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13828
更新日期:2021-01-24 00:00:00
abstract::A 78-year-old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground-glass opacities (GGOs) in both the lower lung lobes; drug-induced pneumonia was speculated. Eosinophil cou...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13848
更新日期:2021-01-21 00:00:00
abstract::Both crizotinib and osimertinib have been reported to have an adverse effect of interstitial pneumonitis in the treatment of non-small cell lung cancer (NSCLC). Here, we report the case of a 60-year-old male patient with advanced NSCLC resistant to osimertinib. Crizotinib was administered in combination with osimertin...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13785
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:Uniportal video-assisted thoracoscopic surgery (VATS) is being more widely used in lung cancer, yet reports on its application in pneumonectomies are limited. This study aimed to evaluate the safety and feasibility of uniportal video-assisted thoracoscopic left pneumonectomy for lung cancer. METHODS:A serie...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13728
更新日期:2021-01-06 00:00:00
abstract::A 60-year-old woman was urgently admitted to our hospital because of vertigo and left hemiplegia. Laboratory examination showed thrombocytopenia, high levels of D-dimer and carcinoembryonic antigen. Brain magnetic resonance imaging (MRI) revealed multiple bilateral cerebral infarctions. Chest computed tomography (CT) ...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13794
更新日期:2020-12-21 00:00:00
abstract:BACKGROUND:Next-generation sequencing (NGS) has been implemented in clinical oncology to analyze multiple genes and to guide targeted therapy; however, little is known about the performance of the Oncomine Dx Target Test compared with conventional single gene tests for detecting EGFR mutations. The objective of this st...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13767
更新日期:2020-12-12 00:00:00
abstract:INTRODUCTION:VATS pulmonary segmentectomy is increasingly proposed as a parenchyma-sparing resection for tumors smaller than 2 cm in diameter. The aim of this study was to compare short-term oncological results and local control in solid non-small cell lung cancers (NSCLCs) <2 cm surgically treated by intentional VATS ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13766
更新日期:2020-12-03 00:00:00
abstract::Tyrosine kinase inhibitors are used as first-line treatment for non-small cell lung cancer (NSCLC) patients harboring driver mutations in EGFR, ALK, ROS1, and BRAF. Currently, standard molecular testing approaches help identify single genes for such targetable driver mutations in NSCLC; however, next-generation sequen...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13694
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Early diagnosis improves the prognosis for non-small cell lung cancer (NSCLC); therefore, there is a pressing need for effective diagnostic methods for NSCLC. Increasing evidence indicates that serum exosomal micro RNAs (miRNAs) represent promising diagnostic and prognostic markers for multiple cancers. Here...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13644
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:To distinguish early-stage lung cancer from benign disease in pulmonary nodules, especially lesions with ground-glass opacity (GGO), we assessed gene mutations of ctDNA in peripheral blood using targeted next-generation sequencing (NGS). METHODS:Single pulmonary nodule patients without mediastinal lymph nod...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13741
更新日期:2020-11-16 00:00:00
abstract::A clinical trial of immune checkpoint inhibitors for advanced non-small cell lung cancer reported an overall survival plateau with a long tail to the survival curve, suggesting that immune checkpoint inhibitors prolong survival. However, little evidence supports the efficacy of immune checkpoint inhibitors as neoadjuv...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13663
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The prognostic effect of molecular subtypes on male breast cancer (MBC) remains unclear. The aim of this study was to evaluate the clinicopathological and prognostic factors of MBC patients. METHODS:From 1 January 1990 to 31 December 2014, the data of 152 MBC and 304 female breast cancer (FBC) patients were...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13611
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Plasmid construction of small fragments of interest (such as insertion of small fragment marker genes, expression of shRNA, siRNA, etc) is the basis of many biomolecular experiments. Here, we describe a method to clone short DNA into vectors by polymerase chain reaction (PCR), named one-step PCR cloning. Our...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13660
更新日期:2020-11-01 00:00:00
abstract::After sternal tumor resection, reconstruction of chest wall defects is still a challenging part of thoracic surgery. Three-dimensional (3D)-printed titanium alloy prosthesis implants provide an effective solution. The bionic bone trabecular micropore structure, which is beneficial to the human body, increases stabilit...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13655
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Breast cancer (BC) is a heterogeneous malignant tumor that threatens the health of women worldwide. Hsa_circRNA_0000518 (circ_0000518) has been revealed to be upregulated in BC tissues. However, the role and mechanism of circ_0000518 in BC are indistinct. METHODS:Quantitative real-time polymerase chain reac...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13641
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:S-1 monotherapy is effective and feasible for previously treated patients with advanced non-small cell lung cancer (NSCLC). However, it is not clear whether its effectiveness and tolerability in elderly patients are equivalent to those in younger patients. Hence, this study aimed to evaluate the efficacy and...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13622
更新日期:2020-10-01 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) activate host antitumor immunity to kill tumor cells. However, ICI therapy may be accompanied by a series of immunotherapy-related adverse effects (irAEs) caused by activated autoreactive T cells. Glucocorticoids are the mainstream therapy for irAEs. However, the usage, dosage and c...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13589
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Advanced non-small cell lung cancer (NSCLC) has a high mortality rate and poor prognosis. However, outcomes have gradually improved after the introduction of novel immunotherapies, including immune checkpoint inhibitors (ICIs). Although programmed death-ligand 1 (PD-L1) expression in tumor tissues is a known...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13653
更新日期:2020-10-01 00:00:00
abstract::Here, we report two cases of advanced non-small cell lung cancer (NSCLC) in patients with negative driver genes who received ICI treatment for less than two years but continued to benefit from their administration after drug withdrawal. The first patient was diagnosed with left lung adenocarcinoma, cT1cN3M1c, stage IV...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13600
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Esophageal cancer is among the leading cancer types in Inner Mongolia. This study aimed to investigate the incidence and mortality rates of esophageal cancer in 2015 and the trends in these rates in the 2010-2015 period in this region. METHODS:National Colorectal Cancer Roundtable (NCCR) screening methods a...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13552
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:A single institution retrospective analysis of 124 non-small cell lung carcinoma (NSCLC) patients was performed to identify whether disease-free survival (DFS) achieves incremental values when radiomic and genomic data are combined with clinical information. METHODS:Using the least absolute shrinkage and se...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13568
更新日期:2020-09-01 00:00:00
abstract::Atezolizumab was the first immune checkpoint inhibitor (ICI) to be introduced as a first-line treatment option for extensive-stage small cell lung cancer (ES-SCLC), in combination with carboplatin and etoposide (CE) chemotherapy. However, SCLC treatment options after progression to first-line chemotherapy are limited,...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13588
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:CalliSpheres are drug-eluting beads used for tumor artery embolization, with clinical benefits in a number of cancer types. The aim of the study was to examine the clinical benefits and complications of patients with stage II-IV lung cancer treated with CalliSpheres drug-eluting beads for embolization versus...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13522
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Lung cancer is the leading cause of cancer-related deaths. Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective for advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations, some patients experience little or no response. The Glasgow prognostic score (GPS...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13526
更新日期:2020-08-01 00:00:00
abstract::Double aortic arch (DAA) is a rare congenital anomaly of the heart and aorta in which a vascular ring that surrounds the trachea and esophagus is formed. In most patients, respiratory distress and dysphagia develop in childhood, and asymptomatic adult patients are rarely known. Herein, we describe a patient with lung ...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13545
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the risk factors of postoperative complications and reliable prognostic factors of long-term survival in HIV-infected patients with non-small cell lung cancer (NSCLC). METHODS:HIV-infected patients with NSCLC who underwent surgical treatment were retrospectively ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13519
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The abundance of tumor infiltrating CD8 T cells is an important parameter for antitumor effect of PD-1/PD-L1 immune checkpoint inhibitors, which is less in epidermal growth factor receptor (EGFR) mutation than wild-type non-small cell lung cancer (NSCLC). The mechanism still requires further study. METHODS:...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13504
更新日期:2020-08-01 00:00:00
abstract::The main recurrence pattern for lung cancer patients after radical surgery is distant metastasis. The probability of pancreatic metastasis in patients diagnosed with lung squamous cell carcinoma is 0.02%, with a poor prognosis. Chemotherapy is the preferred treatment for recurrence. Single lesions or oligometastasis c...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13427
更新日期:2020-07-01 00:00:00
abstract::Several authors have previously reported that patients with pulmonary combined large cell neuroendocrine cancer ( LCNEC) have a poor prognosis and there is no consensus on the treatment strategy for combined LCNEC as well as LCNEC. Here, we report the case of a long-term survivor with pulmonary combined LCNEC. The pat...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13471
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The five-year survival rate of lung adenocarcinoma patients (LUAD) is very low,and the methods of predicting survival are a great obstacle for LUAD therapies. Endothelin receptor type B (EDNRB) gene is associated with tumorigenesis. In this study, we aimed to evaluate the predictive value of EDNRB on LUAD. ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13474
更新日期:2020-07-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely used in patients with EGFR-mutant lung cancer. Meanwhile, thermal ablation such as microwave ablation has been an option for selected patients. Herein, we describe three cases of pneumothorax that occurred in microwave ablation (MWA) ...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13466
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the oncological prognosis and neurological outcomes for patients with thymic epithelial tumors (TETs) after thymectomy. METHODS:Consecutive patients with TETs who underwent thymectomy at Beijing Hospital from January 2011 to December 2018 were retrospectively enrolled into the study. Clinical, p...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13464
更新日期:2020-07-01 00:00:00
abstract::In patients with non-small cell lung cancer (NSCLC), stereotactic radiotherapy (SRT) is one of the standard therapies for those suffering with intracranial metastatic NSCLC. Radiation-induced necrosis (RIN) sometimes occurs as the result of the delayed effects of SRT. The magnetic resonance imaging (MRI) of RIN typica...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13494
更新日期:2020-07-01 00:00:00
abstract::In recent years, studies have found that E2F1, a downstream effector of caveolin-1 (Cav-1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1-MFN2 axis as a regulator of mitophagy. Our data establish a new novel paradig...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13408
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Sphingosine 1-phosphate (S1P), a bioactive lipid, has been shown to mediate cancer processes. Therefore, accurate qualitative and quantitative determination is essential. The current assay method is still cumbersome to be of practical use worldwide and the aim of this study was therefore to develop a fast, a...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13409
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) is a major type of lung cancer with high morbidity and high mortality. miR-874 has been determined to play a role in tumor suppression in several cancers. The purpose of our study was to detect the biological mechanisms of miR-874 and AQP3 in NSCLC. METHODS:CCK-8 and Trans...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13428
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:If anaplastic lymphoma kinase (ALK) gene rearrangement in lung cancer is identified, ALK-tyrosine kinase inhibitors (ALK-TKIs) can be an effective treatment. However, the details of drug-induced lung injury (DILI) caused by ALK-TKI, which can be a serious side effect of ALK-TKIs, remains unclear. This study ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13416
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Connective tissue disease increases the risk of lung cancer, but whether rheumatoid arthritis (RA) has an effect on the overall survival (OS) rate in this population has not been well studied. METHODS:Patients diagnosed with lung cancer between January 2015 and December 2017 were enrolled in this retrospect...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13388
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC). While rapid progression (RP) has been proposed as a non-negligible pattern of response to ICIs, its definition and related factors remain unclear. This study aimed to develop a clinical definition of ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13370
更新日期:2020-05-01 00:00:00
abstract::Here, we present a case of invasive thymoma with intraluminal growth into the left and right brachiocephalic veins, superior vena cava and the right atrium. Resection of the mass, double partial upper lobe lobectomy and superior vena cava, and left and right brachiocephalic vein replacement were performed. Pathologica...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13242
更新日期:2020-05-01 00:00:00