Abstract:
BACKGROUND:Malignant pleural mesothelioma (MPM) is an aggressive cancer refractory to current therapies. Reduced expression of micro ribonucleic acid (miR)-591 in a range of cancer types has suggested it is a potent tumor suppressor, and overexpression has been shown to inhibit tumor cell growth. The role of miR-591 in MPM is largely unknown. METHODS:miR-591 was over-expressed in vitro using micro RNA mimics in three MPM cell lines (H513, H2052, H2373), and effects on tumor cell growth, proliferation, invasion, and target gene expression were assessed. RESULTS:miR-591 mimic was introduced into MPM cell lines to overexpress this microRNA. The cellular growth, proliferation, and invasive capability was significantly inhibited after overexpression of miR-591. Growth inhibition caused by miR-591 correlated with upregulation of p21 and Bax. Reduced invasive capability correlated with downregulation of matrix metalloproteinase-2 and transforming growth factor-β1. CONCLUSION:miR-591 is a potent tumor suppressor in MPM. Overexpression of miR-591 may represent a novel therapeutic approach for MPM.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Cheng S,Xu Y,Shi Z,Lin Y,Hoang CD,Zhang Xdoi
10.1111/1759-7714.12336subject
Has Abstractpub_date
2016-04-26 00:00:00pages
340-7issue
3eissn
1759-7706issn
1759-7714pii
TCA12336journal_volume
7pub_type
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