Abstract:
BACKGROUND:Uridine 5'-diphospho-glucuronosyltransferase 1A1 (UGT1A1*27) is known to impair the effect of UGT in basic research; however, little clinical investigation has been conducted. To evaluate the effect of the UGT1A1*27 polymorphism in irinotecan therapy, we conducted a prospective study. METHODS:Eligibility criteria included: lung cancer patients; scheduled irinotecan therapy doses of single ≥ 80, combination ≥ 50, radiation with single ≥ 50, or radiation with combination ≥ 40 mg/m(2); age ≥ 20; and Eastern Cooperative Oncology Group performance score (PS) 0-2. Patients were examined for UGT1A1*28 and *6 polymorphisms and received irinotecan. When the UGT1A1*28 polymorphism was detected, a search for UGT1A1*27 was conducted. Fifty patients were enrolled, with 48 patients determined eligible. RESULTS:UGT1A1 polymorphisms *28/*28, *6/*6, *28/*6, *28/-, *6/-, -/- observed 0 (0%), 1 (2%), 1 (2%), 7 (15%), 17 (35%) and 22 (46%), respectively. UGT1A1*27 were examined in nine patients including one ineligible patient; however, no polymorphisms were found. The study ceased after interim analysis. In an evaluation of the side effects of irinotecan, patients with UGT1A1*28 and UGT1A1*6 polymorphisms had a higher tendency to experience febrile neutropenia than wild type (25% and 32% vs. 14%). Incidences of grade 3/4 leukopenia and neutropenia were significantly higher in patients with UGT1A1*28 polymorphisms compared with wild type (75% vs. 32%, P = 0.049; 75% vs. 36%, P = 0.039, respectively). CONCLUSION:Our prospective study did not locate the UGT1A1*27 polymorphism, suggesting that UGT1A1*27 does not significantly predict severe irinotecan toxicity in cancer patients.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Fukuda M,Suetsugu T,Shimada M,Kitazaki T,Hashiguchi K,Kishimoto J,Harada T,Seto T,Ebi N,Takayama K,Sugio K,Semba H,Nakanishi Y,Ichinose Ydoi
10.1111/1759-7714.12360subject
Has Abstractpub_date
2016-07-01 00:00:00pages
467-72issue
4eissn
1759-7706issn
1759-7714pii
TCA12360journal_volume
7pub_type
杂志文章相关文献
Thoracic Cancer文献大全abstract::In patients with non-small cell lung cancer (NSCLC), stereotactic radiotherapy (SRT) is one of the standard therapies for those suffering with intracranial metastatic NSCLC. Radiation-induced necrosis (RIN) sometimes occurs as the result of the delayed effects of SRT. The magnetic resonance imaging (MRI) of RIN typica...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13494
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Growing evidence indicates that high phosphoserine phosphatase (PSPH) expression is associated with tumor prognosis in many types of cancers. However, the role of PSPH in non-small cell lung cancer (NSCLC) is unclear. The purpose of this study was to investigate the clinical significance of PSPH in NSCLC. M...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13064
更新日期:2019-05-01 00:00:00
abstract::The extravasation of cytotoxic agents into subcutaneous tissue is a serious complication of chemotherapy. Unfortunately, if such extravasation occurs into the pleural space, limited data is available to guide appropriate management. We present the first report in the literature of video-assisted thoracoscopy combined ...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.12430
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:We explored correlations between the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, epidermal growth factor receptor (EGFR) mutation status, and prognosis. METHODS:Data from 293 patients with lung adenocarcinoma were classifi...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12419
更新日期:2017-05-01 00:00:00
abstract::Immune checkpoint inhibitors that block the programmed death 1/programmed death ligand 1 pathways are widely used to treat advanced lung cancers. There are seldom cases of histologic transformation reported after treatment with immunotherapy. Here, we report the case of a 69-year-old man with stage IV lung squamous ce...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13312
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Approximately 15% of lung cancer patients are diagnosed in early stages. Microscopic proof of disease cannot always be obtained because of comorbidity or reluctance to undergo invasive diagnostic procedures. In the current study, survival data of patients with and without pathology are compared. METHODS:One...
journal_title:Thoracic cancer
pub_type: 临床试验,杂志文章
doi:10.1111/1759-7714.12966
更新日期:2019-02-01 00:00:00
abstract::Patients with EGFR-mutated non-small cell lung cancer (NSCLC) exhibit resistance to EGFR-tyrosine kinase inhibitors (TKIs) within 9-14 months of therapy. Recently, EGFR-mutated NSCLC has demonstrated the potential for heterogeneity; therefore, the manner of clonal heterogeneity may impact the duration of progression-f...
journal_title:Thoracic cancer
pub_type: 杂志文章,多中心研究
doi:10.1111/1759-7714.12923
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:A single institution retrospective analysis of 124 non-small cell lung carcinoma (NSCLC) patients was performed to identify whether disease-free survival (DFS) achieves incremental values when radiomic and genomic data are combined with clinical information. METHODS:Using the least absolute shrinkage and se...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13568
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:To compare the efficiency and toxicity of bevacizumab by intrapleural or intravenous infusion in the management of malignant pleural effusion in patients with non-small-cell lung cancer (NSCLC). METHODS:Sensitizing mutation negative NSCLC patients with malignant pleural effusion were randomized into two gro...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13238
更新日期:2020-01-01 00:00:00
abstract::Lung cancer is globally one of the leading causes of malignant tumor-related mortality and ranks as having the highest incidence found in men and second in women. Osimertinib is a drug used to target lung cancer but its toxicity is not fully understood. Here we present a case of lung adenocarcinoma in a 78-year-old ma...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13127
更新日期:2019-07-01 00:00:00
abstract::This article features the case study of a 32-year-old female patient who had undergone surgery to remove a cervical spine tumor and who later developed cervical esophagus necrosis secondary to the erosion caused by an osteosynthesis 13 years after her prosthetic cervical surgery. Barium swallow did not show anything a...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/j.1759-7714.2012.00112.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:This study investigates the outcome of synchronous stage IV non-small cell lung cancer (NSCLC) patients who received radical thoracic radiotherapy (TRT). METHODS:We retrospectively reviewed the charts of stage IV NSCLC patients treated with TRT between January 2007 and December 2011. Radiotherapy was consid...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12305
更新日期:2016-03-01 00:00:00
abstract::A clinical trial of immune checkpoint inhibitors for advanced non-small cell lung cancer reported an overall survival plateau with a long tail to the survival curve, suggesting that immune checkpoint inhibitors prolong survival. However, little evidence supports the efficacy of immune checkpoint inhibitors as neoadjuv...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13663
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Capn4 and ZEB1 play important roles in the metastasis of several types of cancer. However, the roles and relationship of Capn4 and ZEB1 in esophageal squamous cell carcinoma (ESCC) remain unclear. METHODS:ESCC tumor tissues and corresponding normal esophageal epithelial tissues were obtained from 86 patient...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12893
更新日期:2019-01-01 00:00:00
abstract::Multiple lung nodules caused by pneumonia are a rare presentation in intercostal hemangioma. We experienced a case with intercostal hemangioma that presented with multiple metastasized lung nodules caused by pneumonia, which had previously been misdiagnosed as sarcoma six months earlier. The patient was treated for pn...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/j.1759-7714.2010.00024.x
更新日期:2010-11-01 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The unique spectrum of immune-related adverse events (IrAEs) may occur during treatment. Dermatologic toxicities appear to be one of the most prevalent immunotherapy-related adverse events. The most common symptoms are maculopapular rash and pru...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13275
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Vagus nerve and recurrent laryngeal nerve (RLN) injury are not rare complications of lung cancer surgery and can cause lethal consequences. Until now, no optimal method other than paying greater attention during surgery has been available. METHODS:Four patients underwent lung surgery that involved RLN or va...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12619
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates from the pleura and has a poor prognosis. Eligible patients can benefit from surgery, but their survival is affected by many factors. Therefore, we created a graphic model that could predict the prognosis of surgically treate...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13063
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor-tyrosine kinase inhibitors (EGFR-TKIs) are one of the effective medicines in advanced lung adenocarcinoma leptomeningeal metastasis (LM) treatment in recent years. METHODS:This paper reports two cases of advanced lung adenocarcinoma with exon-EGFR19 mutation. LM occurred during gefit...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12049
更新日期:2014-01-01 00:00:00
abstract::Selected patients with non small-cell lung cancer (NSCLC) with mediastinal lymph node involvement may have a survival benefit from surgical resection, particularly if mediastinal nodal down-staging occurs after induction therapy and complete resection is achieved with lobectomy. Accurate re-staging of the mediastinum ...
journal_title:Thoracic cancer
pub_type: 杂志文章,评审
doi:10.1111/j.1759-7714.2011.00097.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Plasmid construction of small fragments of interest (such as insertion of small fragment marker genes, expression of shRNA, siRNA, etc) is the basis of many biomolecular experiments. Here, we describe a method to clone short DNA into vectors by polymerase chain reaction (PCR), named one-step PCR cloning. Our...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13660
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The impact of adjuvant treatment for esophageal carcinoma with tumor-negative lymph nodes after upfront radical esophagectomy is still uncertain. This study investigated the effects of postoperative radiotherapy in pT1-3N0 esophageal carcinoma after radical resection. METHOD:We retrospectively identified pT...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13235
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Lung cancer is among the most frequently diagnosed types of cancer worldwide, with high morbidity and mortality. Metastasis accounts for the deadliest and most poorly understood feature of lung cancer. Herein, we demonstrate that SND1 (also known as p100) acts as a candidate metastasis activator and is targe...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12564
更新日期:2018-01-01 00:00:00
abstract::Immunoglobulin light-chain (AL) amyloidosis is a monoclonal plasma cell neoplasm that has a tendency to bleed easily. However, the potential risks of transbronchial biopsy in such cases have not been fully proven. Here, we report a case of parotid and intrathoracic AL amyloid tumors that presented as endobronchial pro...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13159
更新日期:2019-10-01 00:00:00
abstract::Patients undergoing hemodialysis (HD) are frequently elderly with poor performance status and usually cannot withstand chemotherapy because of its toxicities. We report a case of an elderly woman with chronic renal failure undergoing HD who was diagnosed with advanced non-small cell lung cancer and treated with orally...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12263
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF). METHODS:IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical record...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/j.1759-7714.2011.00107.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the patterns and influencing factors of local-regional recurrence of lower thoracic esophageal squamous cell carcinoma (TESCC) after curative resection and to delineate the clinical target volume (CTV) of postoperative radiotherapy (PORT). METHODS:From January 2009 t...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12499
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The mortality rate from disseminated intravascular coagulation (DIC) is higher in patients with lung cancer than in non-lung cancer patients. Moreover, the prevalence of DIC varies among the pathologic types of lung cancer. This study analyzed the relationship between coagulation factors and the pathologic t...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12766
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Lung cancer is a disease with a poor prognosis and psychological impact. Lung cancer causes both physical and psychological burdens on patients, and financial burdens on families and society. The aim of this study was to examine the relationship between depression and influencing factors in non-small-cell lu...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12179
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Immunotherapy is a new paradigm for the treatment of non-small-cell lung cancer (NSCLC), and targeting the PD-1 or PD-L1 pathway is a promising therapeutic option. Although PD-1/PD-L1 inhibitors are more effective than standard chemotherapy in lung cancer, clinicians are afraid to actively use them because o...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12877
更新日期:2018-11-01 00:00:00