Abstract:
BACKGROUND:Epidermal growth factor-tyrosine kinase inhibitors (EGFR-TKIs) are one of the effective medicines in advanced lung adenocarcinoma leptomeningeal metastasis (LM) treatment in recent years. METHODS:This paper reports two cases of advanced lung adenocarcinoma with exon-EGFR19 mutation. LM occurred during gefitinib treatment with an extracranial condition under control. Later, erlotinib was adopted with a recurrent response. RESULTS:The progression free survival of both patients was over six months and their LM was under control for six and a half and nine months, respectively. LM may be sensitive on different levels to different EGFR-TKIs. CONCLUSION:Erlotinib can be used to replace gefitinib if intracranial tumor progress occurs during gefitinib treatment. However, our conclusion still needs to be proven by further clinical research.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Xing P,Li J,Shi Y,Zhang Xdoi
10.1111/1759-7714.12049subject
Has Abstractpub_date
2014-01-01 00:00:00pages
38-42issue
1eissn
1759-7706issn
1759-7714journal_volume
5pub_type
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