Abstract:
BACKGROUND:Pleomorphic carcinoma (PC) of the lung is a rare histological type of lung carcinoma. The association between computed tomography (CT) findings and histology with outcome remains unclear. We examined the relationships between CT features and histopathologic findings, and evaluated the impact of CT features and other clinicopathologic factors on survival. METHODS:Thirty-five consecutive patients with PC of the lung who underwent surgery between October 2010 and December 2015 were enrolled in this study. The 35 tumors were classified with or without air bronchogram in the tumors, and with or without intratumoral ground glass opacity (GGO) on CT. RESULTS:Air bronchogram and GGO were detected in 12 (34.3%) and 5 (14.3%) tumors, respectively. Multivariate analysis revealed that air bronchogram was significantly associated with the presence of adenocarcinoma components with lepidic growth patterns (P = 0.005), and predominance of adenocarcinomas (P = 0.026). GGO was significantly associated with the presence of adenocarcinoma component with lepidic growth pattern (P = 0.010). Air bronchogram was an independent favorable prognostic factor for overall survival, whereas GGO did not have a significant effect on survival. CONCLUSION:Air bronchogram observed in PCs of the lung is strongly related with histological components of the tumor and favorable outcome.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Onoda H,Kimura T,Tao H,Okabe K,Matsumoto T,Ikeda Edoi
10.1111/1759-7714.12638subject
Has Abstractpub_date
2018-06-01 00:00:00pages
718-725issue
6eissn
1759-7706issn
1759-7714journal_volume
9pub_type
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