Abstract:
BACKGROUND:To investigate the correlation between mesenchymal-epithelial transition factor (C-Met) and human epidermal growth receptor 2 (HER2) protein expression in primary lung adenocarcinoma tissues. METHOD:A total of 1479 resected primary lung adenocarcinoma patients were enrolled in the present study for detecting of C-Met and HER2 protein by immunohistochemistry, and correlation analysis was made between the above two biomarkers and related clinicopathological features. RESULT:Both C-Met and HER2 proteins were found to stain highly positive in lung adenocarcinomas, and a positive correlation was found between them (χ2 = 118.5, P = 2.707 × 10-21 ). In addition, HER2 protein expression was correlated with sex, pathological stage, lymph node metastasis, and major subtypes; and C-Met was correlated with sex (P < 0.05). CONCLUSION:The expression of C-Met and HER2 protein in lung adenocarcinoma is highly correlated, and whether it is synergistic in the targeted therapy of lung adenocarcinoma deserves further study.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Yang L,Che Y,Guo L,Zheng B,Wang B,Yang Z,Zhu Y,Li Jdoi
10.1111/1759-7714.12595subject
Has Abstractpub_date
2018-04-01 00:00:00pages
439-444issue
4eissn
1759-7706issn
1759-7714journal_volume
9pub_type
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