Survival analysis via nomogram of surgical patients with malignant pleural mesothelioma in the Surveillance, Epidemiology, and End Results database.

Abstract:

BACKGROUND:Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates from the pleura and has a poor prognosis. Eligible patients can benefit from surgery, but their survival is affected by many factors. Therefore, we created a graphic model that could predict the prognosis of surgically treated patients. METHODS:We retrospectively analyzed data from the Surveillance, Epidemiology, and End Results database from 2004 to 2014 to identify the key factors affecting the prognosis of surgically treated MPM patients. On this basis we built a nomogram to predict survival. We then evaluated the performance of the nomogram in a validation cohort. RESULTS:In a training cohort of 828 cases, independent prognostic factors, including age, gender, histological type, differentiation, N stage, chemotherapy, type of surgery, and lymph node dissection, were identified. We then developed a nomogram to evaluate individual patient survival. In Kaplan-Meier analysis, a higher score in the nomogram was associated with a worse prognosis. We also used a validation cohort consisting of 312 patients to evaluate the performance of the nomogram, which was well calibrated and had good discrimination ability, with concordance indices of 0.715 and 0.656 for the training and validation cohorts, respectively. CONCLUSION:This study has improved our understanding of resected MPM and shown that key factors, including age and histological type, are associated with overall survival. The nomogram is a reliable tool that can help clinicians turn individualized prediction into reality and maximize patient benefit by identifying the most beneficial treatment approach.

journal_name

Thorac Cancer

journal_title

Thoracic cancer

authors

Zhuo M,Zheng Q,Chi Y,Jia B,Zhao J,Wu M,An T,Wang Y,Li J,Zhao X,Yang X,Zhong J,Chen H,Dong Z,Wang J,Zhai X,Wang Z

doi

10.1111/1759-7714.13063

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

1193-1202

issue

5

eissn

1759-7706

issn

1759-7714

journal_volume

10

pub_type

杂志文章
  • Histologic transformation of lung cancer during pembrolizumab therapy: A case report.

    abstract::Immune checkpoint inhibitors that block the programmed death 1/programmed death ligand 1 pathways are widely used to treat advanced lung cancers. There are seldom cases of histologic transformation reported after treatment with immunotherapy. Here, we report the case of a 69-year-old man with stage IV lung squamous ce...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/1759-7714.13312

    authors: Si X,You Y,Zhang X,Wang H,Wang M,Zhang L

    更新日期:2020-03-01 00:00:00

  • Characteristics and long-term outcomes of advanced pleural mesothelioma in Latin America (MeSO-CLICaP).

    abstract:BACKGROUND:Malignant pleural mesothelioma (MPM) is an aggressive tumor, associated with poor prognosis. There is a lack of information about the clinical and pathological features related with survival in the Latin American population. METHODS:The MeSO-CLICaP registry identified 302 patients with advanced MPM diagnose...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12967

    authors: Rojas L,Cardona AF,Trejo-Rosales R,Zatarain-Barrón ZL,Ramírez-Tirado LA,Ruiz-Patiño A,Campos Gómez S,Corrales L,Oblitas G,Bacon L,Martín C,de Lima VCC,Freitas HC,Mas L,Vargas C,Carranza H,Otero J,Pérez MA,González L,

    更新日期:2019-03-01 00:00:00

  • The efficacy of amrubicin third-line chemotherapy in patients with relapsed extensive-disease small-cell lung cancer: A retrospective and historical study in a single institute.

    abstract:BACKGROUND:The efficacy of amrubicin for relapsed small-cell lung cancer (SCLC) has been reported in previous studies. Few reports, however, describe the efficacy and survival benefit of third-line amrubicin chemotherapy in patients with extensive disease (ED)-SCLC. METHODS:We retrospectively analyzed the clinical rec...

    journal_title:Thoracic cancer

    pub_type: 临床试验,杂志文章

    doi:10.1111/1759-7714.13150

    authors: Sonehara K,Tateishi K,Fukushima T,Komatsu M,Yamamoto H,Koizumi T,Hanaoka M

    更新日期:2019-09-01 00:00:00

  • Recurrent response to advanced lung adenocarcinoma with erlotinib developing leptomeningeal metastases during gefitinib therapy and two case reports.

    abstract:BACKGROUND:Epidermal growth factor-tyrosine kinase inhibitors (EGFR-TKIs) are one of the effective medicines in advanced lung adenocarcinoma leptomeningeal metastasis (LM) treatment in recent years. METHODS:This paper reports two cases of advanced lung adenocarcinoma with exon-EGFR19 mutation. LM occurred during gefit...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12049

    authors: Xing P,Li J,Shi Y,Zhang X

    更新日期:2014-01-01 00:00:00

  • Chinese expert consensus on diagnosis and management of acquired respiratory-digestive tract fistulas.

    abstract::Acquired respiratory-digestive tract fistulas occur with abnormal communication between the airways and digestive tract, causing the interflow of gas and liquid. Despite advances in surgical methods and the development of multimodal therapy in recent years, patients with acquired respiratory-digestive tract fistulas c...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12856

    authors: Wang H,Ke M,Li W,Wang Z,Li H,Cong M,Zeng Y,Chen L,Lai G,Xie B,Zhang N,Li W,Zhou H,Wang X,Lin D,Zhou Y,Zhang H,Li D,Song X,Wang J,Wu S,Tao M,Sha Z,Tan Q,Han X,Luo L,Ma H,Wang Z

    更新日期:2018-11-01 00:00:00

  • Influence of different image-guided tracking methods upon the local efficacy of CyberKnife treatment in lung tumors.

    abstract:BACKGROUND:The aim of this study was to explore the influence of image-guided tumor localization modality (Synchrony tracking vs. Xsight spine-based localization) on the local efficacy of CyberKnife treatment in lung cancer and lung metastases. METHODS:Retrospective analysis of 64 patients with pulmonary metastases an...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12174

    authors: Guo Y,Zhuang H,Zhao L,Yuan Z,Wang P

    更新日期:2015-05-01 00:00:00

  • Prevalence, risk factors and survival of lung cancer in the idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF). METHODS:IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical record...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/j.1759-7714.2011.00107.x

    authors: Lee KJ,Chung MP,Kim YW,Lee JH,Kim KS,Ryu JS,Lee HL,Park SW,Park CS,Uh ST,Lee YC,Park SJ,Kim KH,Jeon YJ,Choi WI,Park YB,Kim DS,Jeong SH,Lee JH,Park MS

    更新日期:2012-05-01 00:00:00

  • Decoding tumor mutation burden and driver mutations in early stage lung adenocarcinoma using CT-based radiomics signature.

    abstract:BACKGROUND:Tumor mutation burden (TMB) is an important determinant and biomarker for response of targeted therapy and prognosis in patients with lung cancer. The present study aimed to determine whether radiomics signature could non-invasively predict the TMB status and driver mutations in patients with resectable earl...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13163

    authors: Wang X,Kong C,Xu W,Yang S,Shi D,Zhang J,Du M,Wang S,Bai Y,Zhang T,Chen Z,Ma Z,Wang J,Dong G,Sun M,Yin R,Chen F

    更新日期:2019-10-01 00:00:00

  • Bronchomediastinal fistula detected accidently during palliative radiation therapy.

    abstract::Bronchomediastinal fistula is an extremely rare complication resulting from diseases such as mediastinitis or mediastinal malignancies. In patients with lung cancer, bronchomediastinal fistula formation has rarely been reported, except during post-chemotherapy or post-radiation therapy complications. An 84-year-old vi...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/j.1759-7714.2012.00167.x

    authors: Song SH,Oh YJ,Chae SM,Lee J

    更新日期:2013-08-01 00:00:00

  • Male breast cancer: A closer look at patient and tumor characteristics and factors associated with survival.

    abstract:BACKGROUND:The prognostic effect of molecular subtypes on male breast cancer (MBC) remains unclear. The aim of this study was to evaluate the clinicopathological and prognostic factors of MBC patients. METHODS:From 1 January 1990 to 31 December 2014, the data of 152 MBC and 304 female breast cancer (FBC) patients were...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13611

    authors: Zhao J,Wang B,Zhao J,Mao Y,Liu J,Yang Y

    更新日期:2020-11-01 00:00:00

  • Validated LC-MS/MS method of Sphingosine 1-phosphate quantification in human serum for evaluation of response to radiotherapy in lung cancer.

    abstract:BACKGROUND:Sphingosine 1-phosphate (S1P), a bioactive lipid, has been shown to mediate cancer processes. Therefore, accurate qualitative and quantitative determination is essential. The current assay method is still cumbersome to be of practical use worldwide and the aim of this study was therefore to develop a fast, a...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13409

    authors: Tang X,Chen H,Chen G,Duan C,Fan Q,Li H,Wang Y,Li Z,Shi W,Liu Y

    更新日期:2020-06-01 00:00:00

  • Surgical resection versus stereotactic body radiation therapy in early stage bronchopulmonary large cell neuroendocrine carcinoma.

    abstract:BACKGROUND:Surgery is the standard of care for early stage non-small cell lung cancer (NSCLC). Stereotactic body radiotherapy (SBRT) is another definitive treatment option for those patients who have not been treated surgically. Comparison of approaches is being explored in NSCLC, but has yet to be compared exclusively...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13260

    authors: Lo H,Abel S,Finley G,Weksler B,Colonias A,Wegner RE

    更新日期:2020-02-01 00:00:00

  • The role of palliative chemotherapy for terminally ill patients with advanced NSCLC.

    abstract:BACKGROUND:  To evaluate the conditions of palliative chemotherapy in terminally ill patients with advanced non-small cell lung cancer (NSCLC), and to discuss the potential factors that affect the prognosis of these patients. METHODS:  All 205 terminally ill patients with advanced NSCLC, who died in our hospital durin...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/j.1759-7714.2012.00148.x

    authors: Yang D,Qiu M,Zou LQ,Zhang W,Jiang Y,Zhang DY,Yan X

    更新日期:2013-05-01 00:00:00

  • Metastatic meningeal carcinomatosis from lung cancer: Report of a rare case.

    abstract::Meningeal carcinomatosis (MC) refers to the diffuse or multifocal spread or infiltration of malignant tumors in the pia mater. It is a special distribution type of metastatic tumors in the central nervous system and one of the important reasons of death caused by metastatic malignant tumors. Here, we report a rare cas...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/1759-7714.13243

    authors: Liu H,Liu L,Zhang X,Jin S

    更新日期:2020-01-01 00:00:00

  • Lung adenocarcinoma with tumor resolution and dystrophic calcification after salvage surgery following immune checkpoint inhibitor therapy: A case report.

    abstract::A clinical trial of immune checkpoint inhibitors for advanced non-small cell lung cancer reported an overall survival plateau with a long tail to the survival curve, suggesting that immune checkpoint inhibitors prolong survival. However, little evidence supports the efficacy of immune checkpoint inhibitors as neoadjuv...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/1759-7714.13663

    authors: Sumi T,Uehara H,Masaoka T,Tada M,Keira Y,Kamada K,Shijubou N,Yamada Y,Nakata H,Mori Y,Chiba H

    更新日期:2020-11-01 00:00:00

  • Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis.

    abstract:BACKGROUND:Pleomorphic carcinoma (PC) of the lung is a rare histological type of lung carcinoma. The association between computed tomography (CT) findings and histology with outcome remains unclear. We examined the relationships between CT features and histopathologic findings, and evaluated the impact of CT features a...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12638

    authors: Onoda H,Kimura T,Tao H,Okabe K,Matsumoto T,Ikeda E

    更新日期:2018-06-01 00:00:00

  • Expression of Pax8 is decreased and bortezomib does not increase the iodine uptake in thyroid carcinoma cells.

    abstract::Fundamental treatment for papillary thyroid carcinoma (PTC) involves total or subtotal thyroidectomy. Iodine-131 ((131)I) is routinely utilized to target remnant thyroid cancer and metastasis after thyroidectomy. The effectiveness of other therapeutic modalities remains unsatisfactory; thus, these patients have a poor...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12277

    authors: Wang HJ,Yao JM,Zhang ZW,Zhao JY,Shang HX,Liao L,Dong JJ

    更新日期:2015-11-01 00:00:00

  • Adjuvant radiotherapy for patients with pathologic node-negative esophageal carcinoma: A population based propensity matching analysis.

    abstract:BACKGROUND:The impact of adjuvant treatment for esophageal carcinoma with tumor-negative lymph nodes after upfront radical esophagectomy is still uncertain. This study investigated the effects of postoperative radiotherapy in pT1-3N0 esophageal carcinoma after radical resection. METHOD:We retrospectively identified pT...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13235

    authors: Gao HJ,Shang XB,Gong L,Zhang HD,Ren P,Shi GD,Wei YC,Yu ZT

    更新日期:2020-02-01 00:00:00

  • Lung cancer surgery in HIV-infected patients: An analysis of postoperative complications and long-term survival.

    abstract:BACKGROUND:The purpose of this study was to investigate the risk factors of postoperative complications and reliable prognostic factors of long-term survival in HIV-infected patients with non-small cell lung cancer (NSCLC). METHODS:HIV-infected patients with NSCLC who underwent surgical treatment were retrospectively ...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13519

    authors: Wang L,Chen Y,Wang Y,Liu J,Wen Z,Chen H,Zhu Y,Wang J,Wan L,Li F,Song Y

    更新日期:2020-08-01 00:00:00

  • Comparison of the analytical performance between the Oncomine Dx Target Test and a conventional single gene test for epidermal growth factor receptor mutation in non-small cell lung cancer.

    abstract:BACKGROUND:Next-generation sequencing (NGS) has been implemented in clinical oncology to analyze multiple genes and to guide targeted therapy; however, little is known about the performance of the Oncomine Dx Target Test compared with conventional single gene tests for detecting EGFR mutations. The objective of this st...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.13767

    authors: Sakaguchi T,Iketani A,Furuhashi K,Nakamura Y,Suzuki Y,Ito K,Fujiwara K,Nishii Y,Katsuta K,Taguchi O,Hataji O

    更新日期:2020-12-12 00:00:00

  • Analysis of giant thoracic neoplasms: Correlations between imaging, pathology and surgical management.

    abstract:BACKGROUND:A giant thoracic neoplasm is extremely rare and poorly understood. Our systemic study introduced computed tomography angiography (CTA) with three-dimensional (3D) reconstruction imaging and evaluated correlations between imaging, pathology, and surgical management. METHODS:Data from 45 patients undergoing s...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12448

    authors: Feng Z,Li M,Liu F,Peng Y,Ren W,Xie H,Peng Z

    更新日期:2017-09-01 00:00:00

  • Correlation analysis of mesenchymal-epithelial transition factor protein and human epidermal growth receptor 2 protein expression in 1479 cases of lung adenocarcinoma in China.

    abstract:BACKGROUND:To investigate the correlation between mesenchymal-epithelial transition factor (C-Met) and human epidermal growth receptor 2 (HER2) protein expression in primary lung adenocarcinoma tissues. METHOD:A total of 1479 resected primary lung adenocarcinoma patients were enrolled in the present study for detectin...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12595

    authors: Yang L,Che Y,Guo L,Zheng B,Wang B,Yang Z,Zhu Y,Li J

    更新日期:2018-04-01 00:00:00

  • Bronchoscopic debulking for endobronchial malignancy: Predictors of recanalization and recurrence.

    abstract:BACKGROUND:Central airway obstruction related to endobronchial malignancy is one of the most difficult oncological complications and requires efficient palliative intervention. METHODS:Fifty-three consecutive patients with unresectable endobronchial malignancy receiving bronchoscopic cryotherapy as palliative treatmen...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12248

    authors: Kuo SC,Lo YL,Chou CL,Chung FT,Lin SM,Liu CY,Kuo HP

    更新日期:2015-11-01 00:00:00

  • Analysis of the associated factors for severe weight loss after minimally invasive McKeown esophagectomy.

    abstract:BACKGROUND:This study investigated the risk factors for severe weight loss (SWL) within one year after minimally invasive McKeown esophagectomy. METHODS:Esophageal cancer patients who underwent McKeown esophagectomy between January and July 2017 were prospectively enrolled. Preoperative body weight (PBW) was chosen as...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12934

    authors: Wang P,Li Y,Sun H,Zhang R,Liu X,Liu S,Wang Z,Zheng Y,Yu Y,Chen X,Li H,Zhang J,Liu Q

    更新日期:2019-02-01 00:00:00

  • Case report of apatinib mesylate treatment in rare advanced tracheal adenoid cystic carcinoma.

    abstract::A 57-year-old man was admitted to our department 10 years ago, diagnosed with tracheal adenoid cystic carcinoma. After discontinuing chemotherapy and radiotherapy, the disease recurred in December 2016. Apatinib mesylate (500 mg/day) was administered and computed tomography revealed that his symptoms were significantl...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/1759-7714.12506

    authors: Wang H

    更新日期:2017-11-01 00:00:00

  • Elevated pretreatment neutrophil/white blood cell ratio and monocyte/lymphocyte ratio predict poor survival in patients with curatively resected non-small cell lung cancer: Results from a large cohort.

    abstract:BACKGROUND:The prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12454

    authors: Yuan C,Li N,Mao X,Liu Z,Ou W,Wang SY

    更新日期:2017-07-01 00:00:00

  • Invasive thymoma with intravascular growth into the great veins and right atrium: A case report.

    abstract::Here, we present a case of invasive thymoma with intraluminal growth into the left and right brachiocephalic veins, superior vena cava and the right atrium. Resection of the mass, double partial upper lobe lobectomy and superior vena cava, and left and right brachiocephalic vein replacement were performed. Pathologica...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/1759-7714.13242

    authors: Shen W,Cao Y,Wang X,Zhang P,Zhou Q

    更新日期:2020-05-01 00:00:00

  • Intercostal hemangioma presenting with multiple metastasized lung nodules caused by pneumonia.

    abstract::Multiple lung nodules caused by pneumonia are a rare presentation in intercostal hemangioma. We experienced a case with intercostal hemangioma that presented with multiple metastasized lung nodules caused by pneumonia, which had previously been misdiagnosed as sarcoma six months earlier. The patient was treated for pn...

    journal_title:Thoracic cancer

    pub_type:

    doi:10.1111/j.1759-7714.2010.00024.x

    authors: Mei L,Shi H,Che G

    更新日期:2010-11-01 00:00:00

  • Safety of endobronchial ultrasound-guided transbronchial needle aspiration in patients with lung cancer within a year after percutaneous coronary intervention.

    abstract:BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) may be necessary for patients with incidental lung cancer during or after coronary intervention. Although EBUS-TBNA is quite safe, the safety in patients who recently received percutaneous coronary intervention (PCI) has not been de...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12846

    authors: Gil HI,Choe J,Jeong BH,Um SW,Jeon K,Hahn JY,Kim H,Kwon OJ,Chang YS,Lee K

    更新日期:2018-11-01 00:00:00

  • HMGA2 regulates lung cancer proliferation and metastasis.

    abstract:BACKGROUND:This study aimed to explore the effects of HMGA2 on cell proliferation and metastases in lung cancer and its underlying mechanism. METHODS:HMGA2 expression in lung cancer tissues and its association with overall survival were analyzed based on data from a public database. The roles of HMGA2 were validated v...

    journal_title:Thoracic cancer

    pub_type: 杂志文章

    doi:10.1111/1759-7714.12476

    authors: Gao X,Dai M,Li Q,Wang Z,Lu Y,Song Z

    更新日期:2017-09-01 00:00:00