Abstract:
:Pancreatic adenocarcinoma (PAAD), the most common subtype of pancreatic cancer, is a highly lethal disease. In this study, we integrated the expression profiles of splicing factors (SFs) of PAAD from RNA-sequencing data to provide a comprehensive view of the clinical significance of SFs. A prognostic index (PI) based on SFs was developed using the least absolute shrinkage and selection operator (LASSO) COX analysis. The PI exhibited excellent performance in predicting the status of overall survival of PAAD patients. We also used the percent spliced in (PSI) value obtained from SpliceSeq software to quantify different types of alternative splicing (AS). The prognostic value of AS events was explored using univariate COX and LASSO COX analyses; AS-based PIs were also proposed. The integration of prognosis-associated SFs and AS events suggested the potential regulatory mechanisms of splicing processes in PAAD. This study defined the markedly clinical significance of SFs and provided novel insight into their potential regulatory mechanisms.
journal_name
PeerJjournal_title
PeerJauthors
Rong MH,Zhu ZH,Guan Y,Li MW,Zheng JS,Huang YQ,Wei DM,Li YM,Wu XJ,Bu HP,Peng HL,Wei XL,Li GS,Li MX,Chen MH,Huang SNdoi
10.7717/peerj.8380subject
Has Abstractpub_date
2020-02-11 00:00:00pages
e8380issn
2167-8359pii
8380journal_volume
8pub_type
杂志文章相关文献
PeerJ文献大全abstract:Background:The objective of the present study was to compare the effects of equal-volume resistance training (RT) performed with different training frequencies on muscle size and strength in trained young men. Methods:Sixteen men with at least one year of RT experience were divided into two groups, G1 and G2, that tra...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5020
更新日期:2018-06-22 00:00:00
abstract::According to Spearman's law of diminishing returns (SLODR), IQ test scores are more g saturated among those with low, compared to those with high, ability. The present simulation shows that such difference in saturation can be observed if test scores are affected by a disturbing factor, for example, low motivation, il...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9490
更新日期:2020-07-03 00:00:00
abstract::[This corrects the article DOI: 10.7717/peerj.3954.]. ...
journal_title:PeerJ
pub_type: 杂志文章,已发布勘误
doi:10.7717/peerj.3954/correction-1
更新日期:2017-11-14 00:00:00
abstract:Background:This study sought to better understand the psychometric properties of the SARC-F, by examining the baseline and training-related relationships between the five SARC-F items and objective measures of muscle function. Each of the five items of the SARC-F are scored from 0 to 2, with total score of four or more...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8140
更新日期:2019-11-27 00:00:00
abstract::Turbidity currents are the main drivers behind the transportation of terrestrial sediments to the deep sea, and turbidite deposits from such currents have been widely used in geological studies. Nevertheless, the contribution of turbidity currents to vertical displacement of seawater has rarely been discussed. This is...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10429
更新日期:2020-12-09 00:00:00
abstract::The octopus fauna from the southern Caribbean is an understudied field. However, recent taxonomic work in the Colombian Caribbean has led to the discovery of several new species in the family Octopodidae. To provide molecular evidence for recent descriptions in the area (i.e., Octopus taganga, O. tayrona and Macrotrit...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7300
更新日期:2019-07-29 00:00:00
abstract:Background:Alzheimer's disease (AD) is a prevalent progressive neurodegenerative human disease whose cause remains unclear. Numerous initially highly hopeful anti-AD drugs based on the amyloid-β (Aβ) hypothesis of AD have failed recent late-phase tests. Natural aging (AG) is a high-risk factor for AD. Here, we aim to g...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8682
更新日期:2020-03-20 00:00:00
abstract:Background:To ensure the safety of trees, two NDT (nondestructive testing) techniques, electric resistance tomography and stress wave tomography, were employed to quantitatively detect and characterize the internal decay of standing trees. Comparisons between those two techniques were done to make full use of the indiv...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6444
更新日期:2019-03-05 00:00:00
abstract::Cell immobilization is an alternative to microencapsulation for the maintenance of cells in a liquid medium. However, artificial immobilization carriers are expensive and pose a high safety risk. Okara, a food-grade byproduct from soymilk production, is rich in prebiotics. Lactobacilli could provide health enhancing e...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2701
更新日期:2016-11-10 00:00:00
abstract:Introduction:Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) worldwide. Despite recommendations for HPV vaccination of young women from health authorities, parental concerns were raised whether vaccination could induce unsafe sexual behaviour in young women. Therefore, the primary aim...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8516
更新日期:2020-02-10 00:00:00
abstract::Several aspects of an individual's appearance have been shown to predict personality and related behaviour. While some of these cues are grounded in biology (e.g., the human face), other aspects of a person's appearance can be actively controlled (e.g., clothing). In this paper, we consider a common fashion accessory,...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1210
更新日期:2015-08-27 00:00:00
abstract::The term autobiographical self has been used to refer to a mental state that permits reflection on self-identity and personality and the answer to related questions (Damasio, 1998). It requires the retrieval and integrated assembly of memories of facts and events that define an individual's biography. The neural mecha...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.481
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding of genomic data, the CardioTF database was constructed. The...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2339
更新日期:2016-08-23 00:00:00
abstract::Because microorganisms are sensitive to temperature, ongoing global warming is predicted to influence microbial community structure and function. We used large-scale warming experiments established at two sites near the northern and southern boundaries of US eastern deciduous forests to explore how microbial communiti...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.358
更新日期:2014-04-24 00:00:00
abstract::Palythoa caribaeorum is a zoanthid often dominant in shallow rocky environments along the west coast of the Atlantic Ocean, from the tropics to the subtropics. This species has high environmental tolerance and is a good space competitor in reef environments. Considering current and future scenarios in the global clima...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4777
更新日期:2018-05-17 00:00:00
abstract::The ε subunit from ATP synthases acts as an ATP sensor in the bacterial cell to prevent ATP hydrolysis and thus the waste of ATP under conditions of low ATP concentration. However, the ATP binding affinities from various bacterial organisms differ markedly, over several orders of magnitude. For example, the ATP syntha...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5505
更新日期:2018-09-05 00:00:00
abstract::Engaging in effortful self-control can sometimes impair people's ability to resist subsequent temptations. Existing research has shown that when chronic dieters' self-regulatory capacity is challenged by prior exertion of effort, they demonstrate disinhibited eating and altered patterns of brain activity when exposed ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6550
更新日期:2019-02-28 00:00:00
abstract::Background. A "cafeteria" diet is a self-selected high-fat diet, providing an excess of energy, which can induce obesity. Excess of lipids in the diet hampers glucose utilization eliciting insulin resistance, which, further limits amino acid oxidation for energy. Methods. Male Wistar rats were exposed for a month to "...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2302
更新日期:2016-08-03 00:00:00
abstract::We documented significantly increasing trends in atmospheric loading of ammonium (NH4) and nitrate/nitrite (NO2/3) and decreasing trends in total phosphorus (P) and sulfate (SO4) to Flathead Lake, Montana, from 1985 to 2004. Atmospheric loading of NO2/3 and NH4 increased by 48 and 198% and total P and SO4 decreased by...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.841
更新日期:2015-03-19 00:00:00
abstract:Background:Although integrated pest management (IPM) is essential for conservation agriculture, this method can be inadequate for severely infected fields. The ability to predict the potential occurrence of severe infestation of soil-borne disease would enable farmers to adopt suitable methods for high-risk areas, such...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10290
更新日期:2020-11-17 00:00:00
abstract::Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloi...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9719
更新日期:2020-08-14 00:00:00
abstract::Natural products from the unique environments of sea water and oceans represent a largely unfamiliar source for isolation of new microbes, which are potent producers of secondary bioactive metabolites. These unique life-forms from the marine ecosphere have served as an important source of drugs since ancient times and...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5049
更新日期:2018-06-27 00:00:00
abstract::Trihelix transcription factors play multiple roles in plant growth, development and various stress responses. In this study, we identified 71 trihelix family genes in the soybean genome. These trihelix genes were located at 19 out of 20 soybean chromosomes unevenly and were classified into six distinct subfamilies: GT...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8753
更新日期:2020-03-13 00:00:00
abstract:Objective:To synthetize the scientific evidence on the association between serum lipids and premature mortality in Latin America (LA). Methods:Five data bases were searched from inception without language restrictions: Embase, Medline, Global Health, Scopus and LILACS. Population-based studies following random samplin...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7856
更新日期:2019-10-04 00:00:00
abstract::Melanoma is a global concern and accounts for the major mortality of skin cancers. Herpes simplex virus thymidine kinase gene with ganciclovir (HSV-TK/GCV) is a promising gene therapy for melanoma. Despite its low efficiency, it is well known for its bystander effect which is mainly mediated by gap junction. In this s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7760
更新日期:2019-09-20 00:00:00
abstract::The archaellum, the rotating motility structure of archaea, is best studied in the crenarchaeon Sulfolobus acidocaldarius. To better understand how assembly and rotation of this structure is driven, two ATP-binding proteins, FlaI and FlaH of the motor complex of the archaellum of the euryarchaeon Pyrococcus furiosus, ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4984
更新日期:2018-06-18 00:00:00
abstract:Background and Aim:Water is an increasingly scarce resource while some crops, such as paddy rice, require large amounts of water to maintain grain production. A better understanding of rice drought adaptation and tolerance mechanisms could help to reduce this problem. There is evidence of a possible role of root-associ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7463
更新日期:2019-09-11 00:00:00
abstract::There is growing concern that some bee populations are in decline, potentially threatening pollination security in agricultural and non-agricultural landscapes. Among the numerous causes associated with this trend, nutritional stress resulting from a mismatch between bee nutritional needs and plant community provision...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6329
更新日期:2019-02-27 00:00:00
abstract::Protoporphyrin (PP) and biliverdin (BV) give rise to the enormous diversity in avian egg coloration. Egg color serves several ecological purposes, including post-mating signaling and camouflage. Egg camouflage represents a major character of open-nesting birds which accomplish protection of their unhatched offspring a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3706
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:The primary objective of this cross-sectional study was to estimate the crude, seasonal and cull-reason stratified prevalence of Salmonella fecal shedding in cull dairy cattle on seven California dairies. A secondary objective was to estimate and compare the relative sensitivity (Se) and specificity (Sp) for...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2386
更新日期:2016-08-30 00:00:00