Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils.

Abstract:

:Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins. In this work we show its ability to inhibit both the spontaneous amyloid aggregation of SOD1 as well as elongation of preformed fibrils.

journal_name

PeerJ

journal_title

PeerJ

authors

Musteikyte G,Ziaunys M,Smirnovas V

doi

10.7717/peerj.9719

subject

Has Abstract

pub_date

2020-08-14 00:00:00

pages

e9719

issn

2167-8359

pii

9719

journal_volume

8

pub_type

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