Abstract:
:Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins. In this work we show its ability to inhibit both the spontaneous amyloid aggregation of SOD1 as well as elongation of preformed fibrils.
journal_name
PeerJjournal_title
PeerJauthors
Musteikyte G,Ziaunys M,Smirnovas Vdoi
10.7717/peerj.9719subject
Has Abstractpub_date
2020-08-14 00:00:00pages
e9719issn
2167-8359pii
9719journal_volume
8pub_type
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