Cafeteria diet induce changes in blood flow that are more related with heat dissipation than energy accretion.

Abstract:

:Background. A "cafeteria" diet is a self-selected high-fat diet, providing an excess of energy, which can induce obesity. Excess of lipids in the diet hampers glucose utilization eliciting insulin resistance, which, further limits amino acid oxidation for energy. Methods. Male Wistar rats were exposed for a month to "cafeteria" diet. Rats were cannulated and fluorescent microspheres were used to determine blood flow. Results. Exposure to the cafeteria diet did not change cardiac output, but there was a marked shift in organ irrigation. Skin blood flow decreased to compensate increases in lungs and heart. Blood flow through adipose tissue tended to increase in relation to controls, but was considerably increased in brown adipose tissue (on a weight basis). Discussion. The results suggest that the cafeteria diet-induced changes were related to heat transfer and disposal.

journal_name

PeerJ

journal_title

PeerJ

authors

Sabater D,Agnelli S,Arriarán S,Romero Mdel M,Fernández-López JA,Alemany M,Remesar X

doi

10.7717/peerj.2302

subject

Has Abstract

pub_date

2016-08-03 00:00:00

pages

e2302

issn

2167-8359

pii

2302

journal_volume

4

pub_type

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