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Development of label-free biophysical markers in osteogenic maturation.

Abstract：

:The spatial and temporal changes of morphological and mechanical properties of living cells reflect complex functionally-associated processes. Monitoring these modifications could provide a direct information on the cellular functional state. Here we present an integrated biophysical approach to the quantification of the morphological and mechanical phenotype of single cells along a maturation pathway. Specifically, quantitative phase microscopy and single cell biomechanical testing were applied to the characterization of the maturation of human foetal osteoblasts, demonstrating the ability to identify effective label-free biomarkers along this fundamental biological process.

journal_name

J Mech Behav Biomed Mater

journal_title

Journal of the mechanical behavior of biomedical materials

authors

Bartolozzi A,Viti F,De Stefano S,Sbrana F,Petecchia L,Gavazzo P,Vassalli M

doi

10.1016/j.jmbbm.2019.103581

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

103581

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(19)30760-X

journal_volume

103

pub_type

杂志文章

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