Abstract：
:Treatment with tyrosine kinase inhibitors (TKI) is an effective therapy for children and adolescents with chronic phase of chronic myeloid leukemia (CML). For the majority of patients with CML in low- and middle-income countries (LMIC), imatinib is the TKI of choice for reasons of cost, availability, and experience. Children are exposed to therapy for a greater proportion of their lifetime as compared to adults. The adverse effects of prolonged administration of TKI is a subject of ongoing research, as more experience is collected. Therapy with TKI is currently considered to be life-long. Trials on stopping treatment are ongoing to explore if it may be feasible in selected patients, as reported in adults. Growth-failure is a concerning adverse effect. Currently, it seems unclear if the final height attained is within the expected range of the mid-parenteral height and growth standards. Whether the children will achieve a normal height at the end of their growth potential or remain below the predicted range is critical to decide if therapeutic interventions (E.g., growth hormone therapy, or interruption in TKI) should be considered during the period of growth potential. Research on CML in children is at a relatively slow pace, largely due to the rarity of the disease. This provides a unique opportunity for research in population-dense LMICs, as several tertiary centers tend to have a sizable cohort of children and adolescents with CML on follow-up. This narrative summarises the challenges and opportunities in dealing with CML in children, particularly in reference to a center in LMIC.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Bansal Ddoi
10.1007/s12098-020-03234-xsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
443-450issue
6eissn
0019-5456issn
0973-7693pii
10.1007/s12098-020-03234-xjournal_volume
87pub_type
杂志文章,评审abstract：OBJECTIVE:To determine the safety and efficacy of off label usage of Recombinant activated factor VII (rFVIIa) in children with severe bleeding in non-hemophiliac children with diverse etiologies like leukemia, post hematopoietic stem cell transplantation, dengue shock syndrome and Glanzmann thrombasthenia. METHOD:Med...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0364-6
更新日期：2011-08-01 00:00:00
abstract：:Duplications of the alimentary tract are rare congenital anomalies that may occur at any level from mouth to anus. While the oesophagus and the ileum are the most common sites, duplications of the colon are rare. Two cases of ileocolic intussusceptions in 8-month-old girl and 6-month-old boy who were admitted to our h...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02905736
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of low dose vasopressin on the hemodynamics of neonates with persistent pulmonary hypertension and catecholamine refractory shock. METHODS:This retrospective study was conducted in a level III NICU of a tertiary care teaching hospital, south India. Eighteen neonates with hypoxemic resp...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03519-1
更新日期：2020-10-08 00:00:00
abstract：:Senior-Loken syndrome is a rare entity that combines familial juvenile nephronophthisis with retinal dystrophy. The eye disease may be congenital amaurosis of Leber type or pigmentary retinal degeneration and electroretinogram (ERG) helps in the diagnosis of these varieties. The disease progresses inexorably to chroni...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02758316
更新日期：2006-11-01 00:00:00
abstract：:Sedation is being used increasingly in children to allay anxiety and discomfort. Sedation can also increase the efficiency of performing both diagnostic and therapeutic procedures in children. There are a wide array of available sedation methods that are used by radiologists, gastroenterologists, hematologists/oncolog...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02823860
更新日期：1996-01-01 00:00:00
abstract：:We report here a 3 month old child with empyema thoracis, who developed complications of diaphragmatic palsy and Horner's syndrome. These complications of empyema thoracis have not been reported earlier. We discuss the possible mechanisms for these complications. ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02859293
更新日期：2006-10-01 00:00:00
abstract：:Systemic infection in the newborn is the commonest cause of neonatal mortality. Data from National Neonatal Perinatal Database 2000 suggest that Klebsiella pneumoniae and Staphylococcus aureus are the commonest causes of neonatal sepsis in India. Two forms of clinical presentations have been identified. Early onset se...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02722932
更新日期：2001-12-01 00:00:00
abstract：:This review is to summarize recent developments in the field of mycobacteriology since the diagnosis of tuberculosis remains elusive in spite of our best efforts and great scientific advances. Progress has been made in further improving upon the age old, time tested traditional techniques like microscopy (Auramine-Rho...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:A focal outbreak of hepatitis was detected in a day-care centre for children centrally located in Pune. The source of infection was suspected to be an 11-year-old child who probably got the infection from his school. Seven out of 15 children from day-care centre developed clinical hepatitis. Two cases of secondary inf...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02730929
更新日期：1996-11-01 00:00:00
abstract：:Effective communication with parents is a very important skill for pediatricians especially in a neonatal setup. The authors analyzed non-verbal communication of medical caregivers during counseling sessions. Recorded videos of counseling sessions from the months of March-April 2016 were audited. Counseling episodes w...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2680-6
更新日期：2018-11-01 00:00:00
abstract：:Japanese encephalitis (JE)-epidemics have been reported in many parts of the country. The incidence has been reported to be high among pediatric group with high mortality. The incidence of JE in recent times is showing an increasing trend. It appears that JE may become one of the major public health problems in India,...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02724120
更新日期：2004-07-01 00:00:00
abstract：:Resistance to antimicrobial agents, which was recognized more than 50 years, continues to be a major cause of increased morbidity, mortality and health care cost. Overuse of antibiotics is considered the major contributing factor; however, poor implementation of infection control measures, prolonged hospitalization, a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02724275
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:To examine the effect of parental training on disturbed behavior of early childhood cases presented to the pediatricians. METHODS:The patients who reported in pediatric OPD of the Himalayan Institute of Medical Sciences, Dehradun, with complaints of low learning, poor memory, vertigo, speech problem, stress,...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0401-5
更新日期：2011-08-01 00:00:00
abstract：:The authors present 2 cases of dengue shock syndrome with unusual complications. In the first case, a 14-y-old boy with dengue shock syndrome who required aggressive fluid resuscitation, developed abdominal compartment syndrome (ACS). Patient developed severe shock, increased ventilator requirement and oliguria as a c...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0551-5
更新日期：2012-03-01 00:00:00
abstract：:Celiac disease may present as a cryptogenic liver disorder being found in 5-10 % of patients with a persistent and cryptogenetic elevation of serum aminotransferase activity. In fact, a wide spectrum of liver injuries in children and adults may be related to CD and in particular: (1) a mild parenchymal damage characte...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02790391
更新日期：2006-09-01 00:00:00
abstract：:Retroperitoneum, pelvis and scrotum are unusual sites of lymphangiomas. Retroperitoneal lymphangiomas presenting as inguino-scrotal masses are extremely rare. An unusual case of retroperitoneal lymphangioma extending into scrotum, presenting as acute scrotum is reported due to its unusual location. Complete surgical e...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02726134
更新日期：1997-09-01 00:00:00
abstract：:The advent of AIDS has raised a concern regarding transfusion transmitted diseases. Blood transfusion is safer than ever before through continued improvements in safe donor recruitment, screening of donors, testing of donated blood and appropriate clinical use of blood. The risk of residual infections is further reduc...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02722029
更新日期：2001-02-01 00:00:00
abstract：:Skeletal dysplasia are a relatively common and distinct group of genetic disorders. Even though abnormalities of bone growth are the major clinical manifestations, the pathological process may involve in any body system. Many of these disorders have dire consequences such as neonatal death and most will have life-long...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02723957
更新日期：2000-12-01 00:00:00
abstract：:Publication bias can result from the propensity of researchers to document what is unusual. This can distort the inferences drawn in systematic reviews. To measure the distortion, it has been suggested that a second analysis be done; using weights proportional to the size of the population from which the samples are d...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12098-009-0246-3
更新日期：2009-12-01 00:00:00
abstract：:Syndromic paucity of bile ducts or "Alagille syndrome" is characterized by peculiar facies, chronic cholestasis, posterior embryotoxon, butterfly-like vertebral arch defects and peripheral pulmonary artery hypoplasia or stenosis. We present a two-year-old female child with the 'partial' or 'incomplete' Alagille syndro...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02723701
更新日期：2002-09-01 00:00:00
abstract：:A large number of complications in thalassemia major are due mainly to iron overload. Deferoxamine in iron-overloaded patients has established that chelation therapy, when given at an adequate dose, reduces iron-related complications. Parenteral administration and the daily nuisance of an infusion pump hinder the opti...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-007-0134-7
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of an MRI-specific play therapy intervention on the need for sedation in young children. METHODS:All children in the age group of 4-10 y, who were advised an MRI scan over a period of one year were randomized. Exclusion criteria included children with neurodevelopmental disorder...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12098-015-1917-x
更新日期：2016-03-01 00:00:00
abstract：:Sera were collected from a total of 122 children, comprising 117 cases with undifferentiated fever and 5 cases with dengue hemorrhagic fever (DHF), during June to September 1994 in Karachi, Pakistan. Sera were tested by the IgM-capture ELISA using dengue type 1 (D1), dengue type 2 (D2), West Nile (WN), and Japanese en...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02731055
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:To enumerate the cases of intussusception in Chennai during 2012-2013, describe the clinical profile, outcomes of case management and highlight the importance of systematically collecting this data in lieu of rotavirus vaccine introduction in India. METHODS:Medical records of pediatric intussusception cases ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-016-2152-9
更新日期：2016-10-01 00:00:00
abstract：:Gastric volvulus in children is a rare surgical emergency. We describe 2 cases of gastric volvulus with gastric perforation in association with congenital diaphragmatic hernia. One case presented in infancy after recurrent chest infections with intestinal obstruction. The other case presented in the early neonatal per...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:This study reports the clinical picture and measles virus antibody titres in 32 patients with cases of suspected subacute sclerosing panencephalitis (SSPE). The history of myoclonic jerks, mental regression, inability to walk and slurred speech, were noted in these cases. The EEG showed generalised periodic complexes ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02825445
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVE:To study the clinical profile, immediate outcome and possible risk factors of SE in pediatric age group admitted to pediatric intensive care unit (PICU) in a tertiary care center. METHODS:A retrospective study of case records of 451 neuroemergency patients admitted in PICU in a tertiary care center between J...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02760691
更新日期：2005-02-01 00:00:00
abstract：:Paraphenylene daimine (PPD) is a kind of aromatic amine that is widely used in several industrial products. Women also use PPD added to henna (Lawasonia alba) as a hair dye. Though rare in Western countries, PPD poisoning is quite common in East Africa, India and Middle Eastern countries because it is a traditional pr...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-1074-z
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:Hydrocarbons are a common cause of accidental poisoning in children, with kerosene being the most implicated agent in rural parts of India. However, lately, liquid mosquito repellent ingestion is emerging as an important cause of hydrocarbon (kerosene) poisoning in urban households. METHODS:This is a retros...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03088-y
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:To determine the incidence, pattern, causality, preventability, severity and predictors of adverse drug reactions (ADRs) in pediatric population. METHODS:It was a prospective, observational study that included patients of either sex, of any age treated in the pediatric wards of a tertiary care hospital. Stu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-015-2002-1
更新日期：2016-05-01 00:00:00
