Clinical characteristics of Korean pediatric patients with restless legs syndrome.

Abstract:

OBJECTIVES:Restless legs syndrome (RLS) is a common neurological disorder but it is not sufficiently recognized in children and adolescents. It often overlaps with growing pains in children, and as a result the clinical characteristics of pediatric RLS are not well studied, especially in Asia. The purpose of this study is to investigate the clinical characteristics of pediatric RLS patients in Korea and compare it to those of adult RLS patients. METHODS:We retrospectively reviewed the medical records of all pediatric RLS patients (≤18 years) from January 2015 to December 2018 in a regional tertiary hospital sleep center. We randomly selected adult primary RLS patients without comorbid medical disorders from our sleep center's dataset as controls. The number of controls was determined to be twice the number of pediatric RLS patients according to sample size calculation. The clinical and polysomnographic (PSG) characteristics of both groups were compared. The independent t-test, chi-squared test, and Fisher's exact test were used for analyzing quantitative data between the two groups and p < 0.05 was considered statistically significant. RESULTS:Twenty-nine primary pediatric RLS patients and 57 adult RLS patients were enrolled. Pediatric RLS patients showed equal prevalence between sexes, as opposed to adults where there is female predominance. Ferritin level was significantly lower in pediatric patients, although it remained within the normal range. Also, pediatric RLS patients showed less severe RLS symptoms and had better sleep quality than adults did in both objective and subjective measures. In addition, PLMS was shown to be less common in pediatric RLS patients compared to adults. CONCLUSIONS:Pediatric RLS patients showed relatively mild to moderate RLS symptoms and a smaller likelihood of experiencing PLMS than adult patients, which is comparable to similar western studies. Long-term evaluation of a patient's clinical course through multicenter clinical studies is strongly suggested for the future.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Kim S,Kim KT,Motamedi GK,Cho YW

doi

10.1016/j.sleep.2019.12.016

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

14-18

eissn

1389-9457

issn

1878-5506

pii

S1389-9457(20)30003-4

journal_volume

69

pub_type

杂志文章
  • The impact of aircraft noise exposure on objective parameters of sleep quality: results of the DEBATS study in France.

    abstract:BACKGROUND:Noise in the vicinity of airports is a public health issue. Exposure to aircraft noise has been shown to have adverse effects on health and particularly on sleep. Many studies support the hypothesis that noise at night can affect subjective sleep quality. Fewer studies, however, have performed objective meas...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2018.10.013

    authors: Nassur AM,Léger D,Lefèvre M,Elbaz M,Mietlicki F,Nguyen P,Ribeiro C,Sineau M,Laumon B,Evrard AS

    更新日期:2019-02-01 00:00:00

  • Plasma renin levels and renin-blood pressure relationship in normal-weight and overweight children with obstructive sleep apnea and matched controls.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) has been increasingly linked to elevated blood pressure (BP) and hypertension. Repeated night-time hypoxia in OSA is associated with activation of two critical mechanisms of BP control: the autonomic nervous system and the renin-angiotensin system (RAS). The effects of OSA on th...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2014.05.022

    authors: Shamsuzzaman A,Szczesniak RD,Fenchel MC,Amin RS

    更新日期:2015-01-01 00:00:00

  • Altered cortical excitability in patients with untreated obstructive sleep apnea syndrome.

    abstract:OBJECTIVE:To investigate cortical excitability in patients with obstructive sleep apnea syndrome (OSAS) during wakefulness. METHODS:The authors recruited 45 untreated severe OSAS (all males, mean age 47.2 years, mean apnea-hypopnea index=44.6h(-1)) patients and 44 age-matched healthy male volunteers (mean apnea-hypopn...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2010.02.015

    authors: Joo EY,Kim HJ,Lim YH,Koo DL,Hong SB

    更新日期:2010-10-01 00:00:00

  • Atomoxetine improves sleepiness and global severity of illness but not the respiratory disturbance index in mild to moderate obstructive sleep apnea with sleepiness.

    abstract:BACKGROUND AND PURPOSE:Norepinephrine reuptake inhibitors such as protriptyline have been shown to improve sleepiness in sleep apnea, with or without improvement in the respiratory disturbance index (RDI). This study was performed to evaluate whether the selective norepinephrine reuptake inhibitor atomoxetine improves ...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2007.07.013

    authors: Bart Sangal R,Sangal JM,Thorp K

    更新日期:2008-07-01 00:00:00

  • Assessing health-related quality of life in patients with restless legs syndrome in Korea: comparison with other chronic medical diseases.

    abstract:BACKGROUND:There have been few quality of life (QoL) studies of patients with restless legs syndrome (RLS) in Asian countries. We studied the QoL of patients with RLS and compared it to normal controls and patients with hypertension, type 2 diabetes, or osteoarthritis in Korea. METHODS:A total of 215 RLS patients (141...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2012.05.005

    authors: Cho YW,Kim DH,Allen RP,Earley CJ

    更新日期:2012-10-01 00:00:00

  • Sleep-disordered breathing: impact on functional outcome of ischemic stroke patients.

    abstract:BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) is more prevalent in stroke patients than age- and sex-matched controls, but the relationship between SDB and functional outcome of stroke patients is unclear. The aim of our study was to determine the prevalence of SDB in ischemic stroke and its influence on func...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2008.08.006

    authors: Yan-fang S,Yu-ping W

    更新日期:2009-08-01 00:00:00

  • Do reports of sleep disturbance relate to coronary and aortic calcification in healthy middle-aged women?: Study of women's health across the nation.

    abstract:BACKGROUND:Poor sleep may be associated with the cardiovascular disease (CVD) morbidity and mortality. It is less clear if poor sleep is associated with subclinical CVD. We evaluated cross-sectional associations between self-reported sleep disturbance and duration and calcification in the coronary arteries (CAC) and ao...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2012.11.016

    authors: Matthews KA,Everson-Rose SA,Kravitz HM,Lee L,Janssen I,Sutton-Tyrrell K

    更新日期:2013-03-01 00:00:00

  • A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients.

    abstract:OBJECTIVE:Pulse wave attenuation, which occurs in association with obstructive sleep apnea (OSA), is sympathetically mediated. We compared the effect of Doxazosin (DO, a peripheral alpha-receptor inhibitor) and Enalapril (EN, an ACE inhibitor) on digital vasoconstriction and nocturnal blood pressure (BP) in hypertensiv...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.sleep.2009.10.004

    authors: Zou D,Grote L,Eder DN,Radlinski J,Hedner J

    更新日期:2010-03-01 00:00:00

  • Associations between pain, objective sleep efficiency and cognition in patients with implantable cardioverter defibrillators.

    abstract:INTRODUCTION:Patients with implantable cardioverter defibrillators (ICDs) frequently experience sleep disruption. Prior work shows associations between objective (actigraphic) sleep and cognition in these patients, but whether pain affects associations between measures of sleep fragmentation (eg, sleep efficiency, SE) ...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2020.03.029

    authors: Curtis AF,Roth AJ,Sears SF,Conti JB,Berry RB,Dzierzewski JM,McCrae CS

    更新日期:2020-08-01 00:00:00

  • Correlates of benzodiazepine use in individuals with insomnia.

    abstract:BACKGROUND AND PURPOSE:Although benzodiazepines (BZDs) are commonly used in the treatment of insomnia, there is little information about psychological, health, and sociodemographic correlates associated with their use. OBJECTIVE:This study examined correlates of benzodiazepine use for sleep in a clinical sample of pat...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2004.04.001

    authors: Morin CM,Bélanger L,Bernier F

    更新日期:2004-09-01 00:00:00

  • Prevalence of insomnia and associated socio-demographic factors in a Brazilian community: the Bambuí study.

    abstract:BACKGROUND:Population-based studies of insomnia among adults residing in communities in developing countries are rare. The objectives of this population-based study were to determine the prevalence and factors associated with insomnia among adults (18 years and over) living in a Brazilian town with 15,000 inhabitants (...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/s1389-9457(01)00119-8

    authors: Rocha FL,Guerra HL,Lima-Costa MF

    更新日期:2002-03-01 00:00:00

  • Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study.

    abstract:OBJECTIVE:Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). METHODS:This was a cross-sectional study of 50 polysomnogr...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2020.12.038

    authors: Byun JI,Cha KS,Kim M,Lee WJ,Lee HS,Sunwoo JS,Shin JW,Kim TJ,Moon J,Lee ST,Jung KH,Chu K,Kim MH,Kim HJ,Shin WC,Lee SK,Jung KY

    更新日期:2021-01-02 00:00:00

  • Narcolepsy and the ability to resist sleep.

    abstract::We describe five patients who presented with irresistible daytime sleepiness and who have the clinical and laboratory features of narcolepsy but differ from most patients with narcolepsy in their ability to resist falling asleep during the daytime. All of the patients described partial or complete remission of their s...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/s1389-9457(99)00016-7

    authors: Shechter-Amir D,Wade JA,Moldofsky H

    更新日期:2000-04-01 00:00:00

  • Impact of diagnosing and treating obstructive sleep apnea on healthcare utilization.

    abstract:PURPOSE:Obstructive sleep apnea (OSA) contributes to an increased risk for multiple co-morbidities and decreased quality of life. As a result, OSA patients may have higher usage of healthcare resources which can be mitigated with effective treatment. This study evaluates changes in healthcare utilization (HCU) followin...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2017.07.020

    authors: Walter RJ,Hagedorn SI,Lettieri CJ

    更新日期:2017-10-01 00:00:00

  • A clinical investigation of obstructive sleep apnea syndrome (OSAS) and upper airway resistance syndrome (UARS) patients.

    abstract::Objective: (i) Evaluation of the clinical differences and similarities presented by patients diagnosed as OSAS and UARS subjects. (ii) Evaluation of the ability of a sleep disorders specialist to dissociate the two syndromes based upon clinical evaluation.Population: 314 subjects were included. They were referred to a...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/s1389-9457(99)00011-8

    authors: Guilleminault C,Black JE,Palombini L,Ohayon M

    更新日期:2000-02-01 00:00:00

  • Light exposure in the natural environment: relevance to mood and sleep disorders.

    abstract::In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at ...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.sleep.2006.11.008

    authors: Dumont M,Beaulieu C

    更新日期:2007-09-01 00:00:00

  • Cognitive and behavioral effects of obstructive sleep apnea syndrome in children: a systematic literature review.

    abstract::Obstructive sleep apnea syndrome (OSA) is a common respiratory sleep disorder in children that is believed to adversely affect both quality of life and cognition. The purpose of the present systematic review was to obtain evidence of the impact of OSA on children's cognitive/behavioral abilities from primary studies p...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2017.12.020

    authors: da Silva Gusmão Cardoso T,Pompéia S,Miranda MC

    更新日期:2018-06-01 00:00:00

  • Contribution of transcranial magnetic stimulation in restless legs syndrome: pathophysiological insights and therapeutical approaches.

    abstract::Transcranial magnetic stimulation (TMS) may offer a reliable means to characterize significant pathophysiologic and neurochemical aspects of restless legs syndrome (RLS). Namely, TMS has revealed specific patterns of changes in cortical excitability and plasticity, in particular dysfunctional inhibitory mechanisms and...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.sleep.2019.12.009

    authors: Nardone R,Sebastianelli L,Versace V,Brigo F,Golaszewski S,Pucks-Faes E,Saltuari L,Trinka E

    更新日期:2020-07-01 00:00:00

  • Bad sleep? Don't blame the moon! A population-based study.

    abstract:INTRODUCTION:The aim of this study was to evaluate if there is a significant effect of lunar phases on subjective and objective sleep variables in the general population. METHODS:A total of 2125 individuals (51.2% women, age 58.8 ± 11.2 years) participating in a population-based cohort study underwent a complete polys...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2015.08.002

    authors: Haba-Rubio J,Marques-Vidal P,Tobback N,Andries D,Preisig M,Kuehner C,Vollenweider P,Waeber G,Luca G,Tafti M,Heinzer R

    更新日期:2015-11-01 00:00:00

  • Clinical significance and correlates of behaviorally induced insufficient sleep syndrome.

    abstract:BACKGROUND AND PURPOSE:The aim of this study was to investigate the demographic variables and clinical characteristics of behaviorally induced insufficient sleep syndrome (BIISS) and to compare it with the other major hypersomnia disorders. PATIENTS AND METHODS:One-thousand two-hundred forty-three consecutive patients...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2007.08.018

    authors: Komada Y,Inoue Y,Hayashida K,Nakajima T,Honda M,Takahashi K

    更新日期:2008-12-01 00:00:00

  • Nighttime sleep and daytime functioning (sleepiness and fatigue) in less well-defined chronic rheumatic diseases with particular reference to the 'alpha-delta NREM sleep anomaly'

    abstract::For the past 25 years, the 'alpha-delta NREM sleep abnormality' has been used by some as a defining or legitimizing marker for poorly defined rheumatic diseases such as fibromyalgia and chronic fatigue syndrome. Comprehensive review of the literature reveals no support for such a conclusion. Most studies involve small...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/s1389-9457(00)00028-9

    authors: Mahowald ML,Mahowald MW

    更新日期:2000-07-01 00:00:00

  • Treatment of obstructive sleep apnea syndrome associated with stroke.

    abstract::The association between sleep-disordered breathing and stroke has been a subject of increased interest and research. Obstructive sleep apnea (OSA) is an important risk factor for stroke incidence and mortality. Moreover, OSA is a common clinical outcome after stroke, directly influencing the patient's recovery. The tr...

    journal_title:Sleep medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.sleep.2014.12.017

    authors: Mello-Fujita L,Kim LJ,Palombini Lde O,Rizzi C,Tufik S,Andersen ML,Coelho FM

    更新日期:2015-06-01 00:00:00

  • Reduced sleep spindle activity in children with primary snoring.

    abstract:BACKGROUND:Habitually snoring children are at risk of manifesting disease-related problems even if their sleep studies are overall within normal limits. STUDY OBJECTIVES:To compare sleep spindle activity in children with primary snoring and healthy controls. METHODS:Sleep spindle activity including analysis of fast a...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2019.10.001

    authors: Brockmann PE,Bruni O,Kheirandish-Gozal L,Gozal D

    更新日期:2020-01-01 00:00:00

  • Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP.

    abstract:BACKGROUND:Some patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) who are regular users of nasal continuous positive airway pressure (nCPAP) therapy continue to experience daytime sleepiness that impairs performance and quality of life. A randomized, double-blind, placebo-controlled, parallel-group study...

    journal_title:Sleep medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1389-9457(03)00108-4

    authors: Dinges DF,Weaver TE

    更新日期:2003-09-01 00:00:00

  • Web- vs. telehealth-based delivery of cognitive behavioral therapy for insomnia: a randomized controlled trial.

    abstract:OBJECTIVES:The purpose of our study was to evaluate and compare two methods of service delivery (web-based and telehealth-based) for chronic insomnia with regard to patient preference, clinical effectiveness, and patient satisfaction. METHODS:Our study was a randomized controlled trial with manualized telehealth- and ...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.sleep.2013.10.013

    authors: Holmqvist M,Vincent N,Walsh K

    更新日期:2014-02-01 00:00:00

  • The effects of dexamethasone on sleep in young children with acute lymphoblastic leukemia.

    abstract:PURPOSE:Corticosteroids, which are a mainstay in the treatment of acute lymphoblastic leukemia (ALL), have a well-documented adverse effect on sleep. We sought to characterize the effects of dexamethasone on sleep over an entire 28-day treatment cycle using actigraphy, an objective measure of sleep. METHODS:The sleep ...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2014.11.002

    authors: Rosen G,Harris AK,Liu M,Dreyfus J,Krueger J,Messinger YH

    更新日期:2015-04-01 00:00:00

  • Decreased cerebral vasomotor reactivity in patients with obstructive sleep apnea syndrome.

    abstract:OBJECTIVE:In obstructive sleep apnea syndrome (OSAS), any of the activated neural, vascular, hemodynamic, metabolic, inflammatory, and thrombotic mechanisms may be related to increased cerebrovascular disease and risk of death; however, the possible pathophysiological process between obstructive sleep apnea syndrome an...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2016.09.020

    authors: Oz O,Tasdemir S,Akgun H,Erdem M,Balikci A,Cetiz A,Yucel M,Ulas UH,Demirkaya S,Kutukcu Y,Özgen F

    更新日期:2017-02-01 00:00:00

  • Longitudinal changes in insomnia status and incidence of physical, emotional, or mixed impairment in postmenopausal women participating in the Women's Health Initiative (WHI) study.

    abstract:OBJECTIVES/BACKGROUND:We assessed prevalence and correlates of insomnia; associations between changes in insomnia with incidence of physical, emotional, and mixed impairments (PI, EI, and MI, respectively); and age as a moderator in these relationships. PARTICIPANTS/METHODS:The Women's Health Initiative (WHI) clinical...

    journal_title:Sleep medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.sleep.2014.11.008

    authors: Zaslavsky O,LaCroix AZ,Hale L,Tindle H,Shochat T

    更新日期:2015-03-01 00:00:00

  • Impact of sleep on osteoporosis: sleep quality is associated with bone stiffness index.

    abstract:OBJECTIVE:The aim of the present study was to investigate the impact of sleep on osteoporosis. METHODS:The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases. A total ...

    journal_title:Sleep medicine

    pub_type: 杂志文章

    doi:10.1016/j.sleep.2016.06.029

    authors: Sasaki N,Fujiwara S,Yamashita H,Ozono R,Teramen K,Kihara Y

    更新日期:2016-09-01 00:00:00

  • Treatment of insomnia with tricyclic antidepressants: a meta-analysis of polysomnographic randomized controlled trials.

    abstract:BACKGROUND:Insomnia represents a significant public health burden worldwide. Antidepressants have often been the insomnia treatment of choice in recent decades. Some tricyclic antidepressants (TCAs) have been shown to improve sleep efficiency. OBJECTIVE:Assess the efficacy and safety of TCAs for the treatment of insom...

    journal_title:Sleep medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.sleep.2017.03.007

    authors: Liu Y,Xu X,Dong M,Jia S,Wei Y

    更新日期:2017-06-01 00:00:00