Abstract：
OBJECTIVE:Sleep disturbances are frequently reported in Mowat-Wilson Syndrome (MWS). The current study aimed to evaluate clinical and video-polysomnographic (VPSG) characteristics of the sleep architecture and abnormal electroencephalogram (EEG) patterns during sleep in MWS. METHODS:Sixteen individuals with MWS (range 16 months-25 years), attending the Department of Child Neurology and Psychiatry of the University of Bologna, were included. The "Sleep Disturbances Scale for Children (SDSC)" questionnaire was administered to all parents of MWS patients, and all patients underwent a VPSG recording. RESULTS:The analysis of the SDSC questionnaire revealed disturbances mainly at the sleep-wake transition and in initiating and maintaining sleep. Evaluation of sleep structure in MWS patients showed a significant reduction of total sleep time, an increase of wake after sleep onset and arousal index as compared to normal controls. An EEG pattern characterized by slowing of background activity and poverty of physiological sleep characterisitcs was observed in all patients. Moreover, in patients aged >7 years, anteriorly predominant spike and waves were observed, markedly activated by sleep configuring a sub-continuous or continuous activity. CONCLUSION:Our data (both clinical and VPSG) documented the presence of significant and clinically relevant sleep disturbances in MWS patients. Moreover, we identified a characteristic age-dependent sleep EEG pattern that could provide a new element to assist in the management of MWS.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Di Pisa V,Provini F,Ubertiello S,Bonetti S,Ricci E,Ivanovski I,Caraffi SG,Giordano L,Accorsi P,Savasta S,Raviglione F,Boni A,Grioni D,Graziano C,Garavelli L,Cordelli DMdoi
10.1016/j.sleep.2019.04.011subject
Has Abstractpub_date
2019-09-01 00:00:00pages
44-51eissn
1389-9457issn
1878-5506pii
S1389-9457(19)30126-1journal_volume
61pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract：BACKGROUND:There is a critical need for studies aimed to help clinicians to establish the normal/expected central apnea-hypopnea index (CAHI) at altitudes above sea level and ages other than those reported in the current available studies. The aim of the present study was to develop predictive models useful for determi...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.12.033
更新日期：2020-12-31 00:00:00
abstract：BACKGROUND:Frequent nightmares show signs of hyperarousal in NREM sleep. Nevertheless, idiopathic nightmare disorder is considered a REM parasomnia, but the pathophysiology of REM sleep in relation to frequent nightmares is controversial. Cortical oscillatory activity in REM sleep is largely modulated by phasic and ton...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.07.014
更新日期：2020-11-01 00:00:00
abstract：:Poor sleep quality is very common among pregnant women. Gestational diabetes mellitus (GDM) has been related to various adverse maternal and neonatal outcomes. The aim of this systematic review was to examine the association between poor sleep quality and gestational diabetes risk. Following the Preferred Reporting It...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2019.11.1246
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Contradictory data have been published on the influence of Apolipoprotein E (APOE) epsilon4 allele on obstructive sleep apnea (OSA). The aims of this study were to confirm the presence of specific neuropsychological changes in OSA patients carrying the APOE epsilon4 allele and to clarify if these changes are...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2007.10.015
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To document and provide a micro analysis of the relationship between insomnia and health problems, health-care use, absenteeism, productivity and accidents. PARTICIPANTS AND METHODS:A population-based sample of 953 French-speaking adults from Québec, Canada. Participants were categorized as havi...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.04.005
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVES:Sleep is critical for adolescent health and is influenced by the family environment. In our study, we examined if family structure defined as single- vs. two-parent households affected adolescent sleep. METHODS:Participants were 242 (57% black; 47% boys) healthy adolescents (mean age, 15.7 years). Sleep was...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.10.012
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Mandibular advancement devices (MADs) are one of the treatment options used for the obstructive sleep apnea syndrome (OSAS). At present, MADs are designed with standard titration systems, without considering each patient's anatomical characteristics of the temporomandibular joint and mandible shape. The main...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.04.016
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:This study analyzes sawtooth waves (STW), a characteristic feature of rapid eye movement (REM) sleep, in temporal lobe epilepsy patients in order to test the hypothesis of STW dysfunction in this population. METHODS:Polysomnographic records from 16 patients with temporal lobe epilepsy and 11 con...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2005.02.005
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Esmirtazapine (Org 50081), a high-affinity antagonist at 5-HT2A and H1 receptors, was assessed for its hypnotic efficacy. METHODS:In this double-blind, randomized study, non-elderly patients with primary insomnia (but otherwise healthy) were treated with esmirtazapine (1.5, 3.0, or 4.5 mg) or placebo for tw...
journal_title：Sleep medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.sleep.2015.03.005
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVES:The present study investigated the effectiveness of a school-based sleep education programme in improving key sleep behaviours, sleep knowledge, and sleep hygiene. DESIGN AND METHODS:A cross-sectional cluster-randomised controlled trial with two groups (Intervention and Control) and three assessment time po...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2015.02.534
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Adaptive servo-ventilation (ASV) is a well-established treatment of central sleep apnea (CSA) related to congestive heart failure (CHF). Few studies have evaluated the effectiveness and adherence in patients with CSA of other etiologies, and even less is known about treatment of CSA in patients of post ische...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.06.013
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:We investigated the impact of delayed sleep phase disorder (DSPD) on the daily lives of adolescents and their families. METHOD:In this qualitative study, six adolescents with DSPD, and six parents were given in-depth interviews. Using thematic analysis, we merged open codes into themes that reflected the ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.05.022
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:A social gradient in sleep has been demonstrated across the life span, but previous studies have been cross-sectional and used self-reported socioeconomic status (SES) indicators. Using registry-based data on family income trajectories, the current study examined the association between relative poverty in ch...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.06.005
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:Nightmares are extremely unpleasant and vivid recurring dreams that are accompanied with awakening during sleep. However, earlier studies were mostly conducted with children and adults, with very few studies on nightmares in older adults. This population-based study aims to investigate the prevalence of nigh...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.11.039
更新日期：2020-12-04 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has been considered a promising technique for the treatment of primary insomnia. However, its efficacy and placebo response remains unclear due to limited clinical data. Therefore, we conducted a systematic review to examine the efficacy and placebo respons...
journal_title：Sleep medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.sleep.2019.05.008
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Poor sleep may be associated with the cardiovascular disease (CVD) morbidity and mortality. It is less clear if poor sleep is associated with subclinical CVD. We evaluated cross-sectional associations between self-reported sleep disturbance and duration and calcification in the coronary arteries (CAC) and ao...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2012.11.016
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Very few prospective studies examine the relationship between childhood sleep problems and subsequent substance use. In this study, we examined how sleep problems at ages 3-8 predicted onset of alcohol, cigarette, and marijuana use in adolescence. We also investigated the relationships between childhood slee...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.06.015
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associat...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2018.02.007
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:Type 1 narcolepsy/hypocretin deficiency is characterized by excessive daytime sleepiness, sleep fragmentation, and cataplexy. Short rapid eye movement (REM) latency (≤15 min) during nocturnal polysomnography (PSG) or during naps of the multiple sleep latency test (MSLT) defines a sleep-onset REM sleep period ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.06.007
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND AND PURPOSE:We previously postulated how evolutionary changes in man's upper respiratory tract to facilitate speech, a phenomenon Jared Diamond calls The Great Leap Forward, have predisposed man to obstructive sleep apnea (OSA) [Diamond J. The Third Chimpanzee: the evolution and future of the human animal. N...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2005.03.007
更新日期：2005-11-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the National Institute of Health (NIH)-funded PRIDE Institute in Behavioral Medicine and Sleep Disorders Research at New York University (NYU) Langone Medical Center. The NYU PRIDE Institute provides intensive didactic and mentored research training to junior underrepresented m...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.09.010
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:There are substantial inter-individual differences in infants' longest consecutive sleep duration. However, intra-individual differences are rarely considered. The present study aimed to describe night-to-night variability in achieving 6 or 8 h of consolidated sleep over a 13-night period in 6-month-old infan...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.10.005
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:The present study was conducted to evaluate serum levels of high-sensitivity C-reactive protein (hs-CRP) in newly diagnosed patients with obstructive sleep apnea (OSA). SUBJECTS AND METHODS:Between April 2005 and March 2006, a total of 231 consecutive adult habitual snorers underwent polysomnography (PSG) in...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2007.02.004
更新日期：2008-01-01 00:00:00
abstract：:This article focuses on the contributions made by Michel Jouvet concerning the systems responsible for the muscle atonia of paradoxical sleep (REM sleep). He was the first to describe the brainstem system mechanisms responsible for muscle atonia during paradoxical sleep using pontine cats and localized pontine lesions...
journal_title：Sleep medicine
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.sleep.2018.05.026
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Odor identification and discrimination are reduced in subjects with obstructive sleep apnea syndrome (OSAS), but the pathophysiology of the olfactory dysfunction in OSAS is still poorly understood. Experimental evidence suggests that olfactory impairment could be related to central cholinergic dysf...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.06.021
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:We aimed to investigate subjective sleep quality and polysomnographic sleep structure features in patients with vascular cognitive impairment-no dementia (VCIND). METHODS:Fifty-six patients with VCIND, 48 patients with simple stroke (without cognitive impairment), and 48 control subjects were included. The ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.07.003
更新日期：2013-11-01 00:00:00
abstract：STUDY OBJECTIVES:Using a multi-method design, this study examined the construct validity of the Parent-Child Sleep Interactions Scale (PSIS; Alfano et al., 2013), which measures sleep-related parenting behaviors and interactions that contribute to preschoolers' sleep problems. METHODS:Participants included a community...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.04.002
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Intrinsic variance of the urine proteome limits the discriminative power of proteomic analysis and complicates potential biomarker detection in the context of paediatric sleep disorders. METHODS AND RESULTS:Using a rigorous workflow for proteomic analysis of urine, we demonstrate that gender and diurnal eff...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.01.010
更新日期：2014-05-01 00:00:00
abstract：:This report presents the results of the work by a joint task force of the International and European Restless Legs Syndrome Study Groups and World Association of Sleep Medicine that revised and updated the current standards for recording and scoring leg movements (LM) in polysomnographic recordings (PSG). First, the b...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.10.010
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:Two doses of EVT 201, a partial positive allosteric modulator of the GABA(A) system, were evaluated in elderly primary insomnia patients with daytime sleepiness. PATIENTS AND METHODS:Participants were 149 elderly patients with DSM-IV primary insomnia including evidence of daytime sleepiness (53 males, 96 fem...
journal_title：Sleep medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.sleep.2009.07.012
更新日期：2010-01-01 00:00:00
