当前位置： SCI文献检索 > SLEEP MEDICINE期刊下所有文献 > The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea.

The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea.

Abstract：

BACKGROUND:Contradictory data have been published on the influence of Apolipoprotein E (APOE) epsilon4 allele on obstructive sleep apnea (OSA). The aims of this study were to confirm the presence of specific neuropsychological changes in OSA patients carrying the APOE epsilon4 allele and to clarify if these changes are due to the sole presence of this allele or to its interactions with OSA pathology. METHODS:The APOE genotype was examined in 123 patients with OSA and in 121 controls, together with a series of neuropsychological tests. RESULTS:OSA and control subjects had similar APOE genotype and allele distribution, but when neuropsychological tests were considered, OSA patients showed significantly lower values for verbal long-term (delayed free recall at the Rey auditory-verbal learning test) and working memory (bisyllabic words). Moreover, spatial span was found to be lower in OSA epsilon4 allele carriers than in non-carriers; this difference was not observed in controls. CONCLUSIONS:This study confirms the presence of a verbal memory impairment in OSA patients and provides evidence for a significant interaction of APOE epsilon4 allele and OSA on frontal lobe function in adults, possibly mediated by the presence of specific frontal lobe neuroanatomical changes in these patients.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Cosentino FI,Bosco P,Drago V,Prestianni G,Lanuzza B,Iero I,Tripodi M,Spada RS,Toscano G,Caraci F,Ferri R

doi

10.1016/j.sleep.2007.10.015

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

831-9

issue

8

eissn

1389-9457

issn

1878-5506

pii

S1389-9457(07)00371-1

journal_volume

9

pub_type

杂志文章

相关文献

SLEEP MEDICINE文献大全
  • Predictors of long-term effectiveness to mandibular repositioning device treatment in obstructive sleep apnea patients after 1000 days.

    abstract：OBJECTIVE/BACKGROUND:In obstructive sleep apnea (OSA), long-term adherence to treatment is crucial. This prospective single-center study investigated factors associated with long-term adherence to mandibular repositioning device (MRD) therapy. PATIENTS/METHODS:All OSA patients who had MRD treatment initiated in the pr...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2016.10.004

    authors： Attali V,Chaumereuil C,Arnulf I,Golmard JL,Tordjman F,Morin L,Goudot P,Similowski T,Collet JM

    更新日期：2016-01-01 00:00:00

  • Light exposure in the natural environment: relevance to mood and sleep disorders.

    abstract：:In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at ...

    journal_title：Sleep medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.sleep.2006.11.008

    authors： Dumont M,Beaulieu C

    更新日期：2007-09-01 00:00:00

  • Improved night shift schedule related to the mortality of critically ill patients with Corona Virus Disease 2019.

    abstract：PURPOSE:To determine the relationship between the improved night shift schedule and the mortality of critically ill patients with Corona Virus Disease 2019 (COVID-19). METHODS:According to the time of the implementation of the new night shift schedule, we divided all patients into two groups: initial period group and ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2020.08.010

    authors： Zhang S,Xu Y,Wu K,Wang T,Su X,Han Q,Xi Y,Zhu S,Gao Y,Wang H,Hu Y,Liu C,Zhong N,Ran P,Zhang N

    更新日期：2020-11-01 00:00:00

  • REM sleep behavior disorder in a patient with pontine stroke.

    abstract：:Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently seen in patients with neurodegenerative diseases. It can also be seen in brainstem lesions involving the pons. However, RBD in patients with a pure pontine infarction has been rarely reported. A 68-year-old man had a two-month history of violent beha...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2007.12.002

    authors： Xi Z,Luning W

    更新日期：2009-01-01 00:00:00

  • Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries.

    abstract：BACKGROUND AND PURPOSE:To estimate prevalence and severity (using the International Restless Legs Syndrome Study Group Rating Scale (IRLS)) and to identify risk factors of restless legs syndrome (RLS). PATIENTS AND METHODS:Population-based cross-sectional study; 2005 randomly selected adults 18 years and above partici...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2005.03.008

    authors： Bjorvatn B,Leissner L,Ulfberg J,Gyring J,Karlsborg M,Regeur L,Skeidsvoll H,Nordhus IH,Pallesen S

    更新日期：2005-07-01 00:00:00

  • Long-term side effects of sleep apnea treatment with oral appliances: nature, magnitude and predictors of long-term changes.

    abstract：OBJECTIVES:Oral appliances for the treatment of obstructive sleep apnea (OSA) reduce upper airway collapse by advancing the mandible (OAm) and associated soft tissues. OAm are well tolerated but have side effects, mainly dental movement. It is not yet clear whether there are irreversible skeletal changes associated wit...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2018.12.012

    authors： Hamoda MM,Almeida FR,Pliska BT

    更新日期：2019-04-01 00:00:00

  • Clinical presentation, diagnosis and polysomnographic findings in children with migraine referred to sleep clinics.

    abstract：OBJECTIVE:An association between migraine and sleep disturbances in children was reported, yet limited clinical data exist. The current study addresses the clinical presentation, polysomnographic (PSG) characteristics, and comorbid sleep diagnoses of children with migraine referred to the sleep clinic. PATIENTS:A retr...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2019.04.023

    authors： Armoni Domany K,Nahman-Averbuch H,King CD,Dye T,Xu Y,Hossain M,Hershey AD,Simakajornboon N

    更新日期：2019-11-01 00:00:00

  • Randomized trial of pramipexole for patients with restless legs syndrome (RLS) and RLS-related impairment of mood.

    abstract：OBJECTIVES:Patients with restless legs syndrome (RLS) have an elevated prevalence of mood disorders compared with the general population. We investigated the change of RLS-related mood impairment during treatment of RLS with pramipexole, a dopamine D(3)/D(2) agonist. METHODS:Adults with moderate to very severe RLS wer...

    journal_title：Sleep medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.sleep.2010.08.005

    authors： Montagna P,Hornyak M,Ulfberg J,Hong SB,Koester J,Crespi G,Albrecht S

    更新日期：2011-01-01 00:00:00

  • Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study.

    abstract：BACKGROUND:Hypoxia plays an important role in the development of solid tumors. Intermittent hypoxia is the hallmark of sleep apnea (SA). We tested the hypothesis that SA may increase the risk of breast cancer in Taiwan by using a population-based data set. METHODS:Our study cohort consisted of women diagnosed with SA ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2014.05.026

    authors： Chang WP,Liu ME,Chang WC,Yang AC,Ku YC,Pai JT,Lin YW,Tsai SJ

    更新日期：2014-09-01 00:00:00

  • Treatment of elderly primary insomnia patients with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepiness.

    abstract：OBJECTIVE:Two doses of EVT 201, a partial positive allosteric modulator of the GABA(A) system, were evaluated in elderly primary insomnia patients with daytime sleepiness. PATIENTS AND METHODS:Participants were 149 elderly patients with DSM-IV primary insomnia including evidence of daytime sleepiness (53 males, 96 fem...

    journal_title：Sleep medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.sleep.2009.07.012

    authors： Walsh JK,Salkeld L,Knowles LJ,Tasker T,Hunneyball IM

    更新日期：2010-01-01 00:00:00

  • CPAP therapy improves erectile function in patients with severe obstructive sleep apnea.

    abstract：OBJECTIVES:Erectile dysfunction (ED) is highly prevalent in obstructive sleep apnea (OSA), however, the effect of continuous positive airway pressure (CPAP) therapy on erectile function has not yet been thoroughly investigated in these patients. METHODS:Ninety-four men with severe OSA (ie, with an apnea-hypopnea-index...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2018.03.018

    authors： Schulz R,Bischof F,Galetke W,Gall H,Heitmann J,Hetzenecker A,Laudenburg M,Magnus TJ,Nilius G,Priegnitz C,Randerath W,Schröder M,Treml M,Arzt M,German Sleep Apnea Research Network (GERSAN).

    更新日期：2019-01-01 00:00:00

  • TOX3 gene variant could be associated with painful restless legs.

    abstract：BACKGROUND/OBJECTIVE:Restless legs syndrome (RLS) is a neurological disorder with a strong genetic susceptibility. A painful RLS sub-phenotype has been described previously but the neurobiological basis for this phenotypic variant remains unknown. This study investigated whether any of the six initially discovered geno...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2019.07.003

    authors： Karroum EG,Saini PS,Trotti LM,Rye DB

    更新日期：2020-01-01 00:00:00

  • Clinical significance and correlates of behaviorally induced insufficient sleep syndrome.

    abstract：BACKGROUND AND PURPOSE:The aim of this study was to investigate the demographic variables and clinical characteristics of behaviorally induced insufficient sleep syndrome (BIISS) and to compare it with the other major hypersomnia disorders. PATIENTS AND METHODS:One-thousand two-hundred forty-three consecutive patients...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2007.08.018

    authors： Komada Y,Inoue Y,Hayashida K,Nakajima T,Honda M,Takahashi K

    更新日期：2008-12-01 00:00:00

  • Restless Legs Syndrome and the five-factor model of personality: results from a community sample.

    abstract：OBJECTIVE:To examine personality characteristics as potential mediators of the association between Restless Legs Syndrome (RLS) and psychiatric disorders. METHOD:Revised NEO Personality Inventory traits are compared in respondents with (n=42) versus without (n=982) a diagnosis of RLS in a general population sample. R...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2008.07.004

    authors： Kalaydjian A,Bienvenu OJ,Hening WA,Allen RP,Eaton WW,Lee HB

    更新日期：2009-06-01 00:00:00

  • Preschool children's eating and sleeping habits: late rising and brunch on weekends is related to several physical and mental symptoms.

    abstract：OBJECTIVE:As the relationships of sleep-wake schedule and mealtime with children's behaviors have not often been studied together, we investigated the relationships of these lifestyles variables with preschool children's well-being. METHODS:Using a network survey, we investigated several lifestyle variables of 1000 fa...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2019.03.023

    authors： Fukuda K,Hasegawa T,Kawahashi I,Imada S

    更新日期：2019-09-01 00:00:00

  • Childhood sleep problems, early onset of substance use and behavioral problems in adolescence.

    abstract：BACKGROUND:Very few prospective studies examine the relationship between childhood sleep problems and subsequent substance use. In this study, we examined how sleep problems at ages 3-8 predicted onset of alcohol, cigarette, and marijuana use in adolescence. We also investigated the relationships between childhood slee...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2008.06.015

    authors： Wong MM,Brower KJ,Zucker RA

    更新日期：2009-08-01 00:00:00

  • Construct validity of the parent-child sleep interactions scale (PSIS): associations with parenting, family stress, and maternal and child psychopathology.

    abstract：STUDY OBJECTIVES:Using a multi-method design, this study examined the construct validity of the Parent-Child Sleep Interactions Scale (PSIS; Alfano et al., 2013), which measures sleep-related parenting behaviors and interactions that contribute to preschoolers' sleep problems. METHODS:Participants included a community...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2014.04.002

    authors： Smith VC,Leppert KA,Alfano CA,Dougherty LR

    更新日期：2014-08-01 00:00:00

  • Associations between specific technologies and adolescent sleep quantity, sleep quality, and parasomnias.

    abstract：OBJECTIVE:We tested the hypothesis that weekday bedtime use of six technologies would be significantly associated with eight sleep parameters studied relating to sleep quantity, sleep quality, and parasomnias. METHODS:In our cross-sectional study, we previously administered validated age-appropriate questionnaires (Sc...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2013.08.799

    authors： Arora T,Broglia E,Thomas GN,Taheri S

    更新日期：2014-02-01 00:00:00

  • Relationships between insomnia, long working hours, and long commuting time among public school teachers in Japan: a nationwide cross-sectional diary study.

    abstract：OBJECTIVES:The present study aimed to clarify the prevalence and risk factors of insomnia among public school teachers in Japan by examining the relationships between working hours, commuting time, and insomnia. Time spent on work activities among teachers with insomnia was also investigated. METHODS:This study was a ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2019.09.017

    authors： Hori D,Sasahara S,Oi Y,Doki S,Andrea CS,Takahashi T,Shiraki N,Ikeda T,Ikeda Y,Kambayashi T,Aoki E,Matsuzaki I

    更新日期：2020-11-01 00:00:00

  • Contribution of transcranial magnetic stimulation in restless legs syndrome: pathophysiological insights and therapeutical approaches.

    abstract：:Transcranial magnetic stimulation (TMS) may offer a reliable means to characterize significant pathophysiologic and neurochemical aspects of restless legs syndrome (RLS). Namely, TMS has revealed specific patterns of changes in cortical excitability and plasticity, in particular dysfunctional inhibitory mechanisms and...

    journal_title：Sleep medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.sleep.2019.12.009

    authors： Nardone R,Sebastianelli L,Versace V,Brigo F,Golaszewski S,Pucks-Faes E,Saltuari L,Trinka E

    更新日期：2020-07-01 00:00:00

  • Pramipexole for Chinese people with primary restless legs syndrome: a 12-week multicenter, randomized, double-blind study.

    abstract：BACKGROUND:Restless legs syndrome (RLS) often responds to agents that enhance dopamine neurotransmission. The present 12-week study aimed to evaluate the efficacy and adverse events of pramipexole (PPX) for the treatment of adult, Chinese people with primary RLS. METHODS:A total of 204 Chinese people with RLS were ran...

    journal_title：Sleep medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.sleep.2014.09.015

    authors： Zhang J,Liu B,Zheng Y,Chu T,Yang Z

    更新日期：2015-01-01 00:00:00

  • Psychosocial adjustment following relief of chronic narcolepsy.

    abstract：BACKGROUND AND PURPOSE:No previous research has examined the psychosocial adjustment of chronic narcolepsy patients following efficacious pharmacotherapy. In contrast, considerable research has examined the process of psychosocial adjustment following surgical relief of chronic epilepsy. This process can manifest as a ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2006.08.001

    authors： Wilson SJ,Frazer DW,Lawrence JA,Bladin PF

    更新日期：2007-04-01 00:00:00

  • Sleep quality and gestational diabetes in pregnant women: a systematic review and meta-analysis.

    abstract：:Poor sleep quality is very common among pregnant women. Gestational diabetes mellitus (GDM) has been related to various adverse maternal and neonatal outcomes. The aim of this systematic review was to examine the association between poor sleep quality and gestational diabetes risk. Following the Preferred Reporting It...

    journal_title：Sleep medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.sleep.2019.11.1246

    authors： Zhu B,Shi C,Park CG,Reutrakul S

    更新日期：2020-03-01 00:00:00

  • Night-to-night variability in sleep in cystic fibrosis.

    abstract：OBJECTIVES:The impact of night-to-night variability (NNV) on polysomnography (PSG) has been reported mainly in normal subjects, the elderly and patients with obstructive sleep apnea with focus on changes in the apnea/hypopnea index, rather than measures of nocturnal oxygenation. There is very limited data on NNV in pat...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/s1389-9457(02)00030-8

    authors： Milross MA,Piper AJ,Norman M,Willson GN,Grunstein RR,Sullivan CE,Bye PT

    更新日期：2002-05-01 00:00:00

  • Simple interventions improve re-attendance when treating the sleep apnoea syndrome.

    abstract：BACKGROUND AND PURPOSE:Interventions to improve treatment outcomes in sleep apnoea-hypopnoea syndrome (SAHS) have had mixed success. Most have concentrated on following the use of a continuous positive airway pressure (CPAP) machines; poorer users may not return for machine readings, so any compliance study must take i...

    journal_title：Sleep medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.sleep.2005.09.007

    authors： Lewis KE,Bartle IE,Watkins AJ,Seale L,Ebden P

    更新日期：2006-04-01 00:00:00

  • Sleep apnea increased incidence of primary central nervous system cancers: a nationwide cohort study.

    abstract：INTRODUCTION:Obstructive sleep apnea (OSA) was associated with increased incidence of all cancers. We aimed to determine the risk for primary central nervous system (CNS) cancers in patients with sleep apnea syndrome. METHODS:A total of 23,055 incident cases of newly diagnosed sleep apnea syndrome (sleep apnea group) ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2013.11.782

    authors： Chen JC,Hwang JH

    更新日期：2014-07-01 00:00:00

  • Obstructive sleep apnea in Parkinson's disease: a study in 239 Chinese patients.

    abstract：OBJECTIVE:Our objective was to explore the clinical characteristics of Parkinson's disease (PD) comorbidity with obstructive sleep apnea (OSA), explore the correlation between OSA and PD features and identify factors that are independent predictors of OSA in PD patients. METHODS:In sum, 239 PD patients were divided in...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2019.11.1251

    authors： Shen Y,Shen Y,Dong ZF,Pan PL,Shi HC,Liu CF

    更新日期：2020-03-01 00:00:00

  • Are there distinctive sleep problems in Angelman syndrome?

    abstract：:Angelman syndrome is a neurogenetic condition characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioral phenotype that includes sleep problems. It is caused by lack of expression of the UBE3A gene on the maternal chromosome 15q11-q13. Although part of the diagnostic ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2007.07.001

    authors： Pelc K,Cheron G,Boyd SG,Dan B

    更新日期：2008-05-01 00:00:00

  • Age- and gender-specific associations of napping duration with type 2 diabetes mellitus in a Chinese rural population: the RuralDiab study.

    abstract：BACKGROUND:The consistency and strength of the relationship between napping duration and type 2 diabetes mellitus (T2DM) remained uncertain, especially in the rural population. The purpose of this study was to explore the relationship between napping duration and T2DM in a Chinese rural population. METHODS:A total of ...

    journal_title：Sleep medicine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.sleep.2016.09.004

    authors： Liu R,Li Y,Wang F,Liu X,Zhou H,Wang P,Fan J,Xu F,Yang K,Hu D,Bie R,Wang C

    更新日期：2017-05-01 00:00:00

  • Moving into poverty during childhood is associated with later sleep problems.

    abstract：OBJECTIVE:A social gradient in sleep has been demonstrated across the life span, but previous studies have been cross-sectional and used self-reported socioeconomic status (SES) indicators. Using registry-based data on family income trajectories, the current study examined the association between relative poverty in ch...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2017.06.005

    authors： Sivertsen B,Bøe T,Skogen JC,Petrie KJ,Hysing M

    更新日期：2017-09-01 00:00:00