Abstract：
:Angelman syndrome is a neurogenetic condition characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioral phenotype that includes sleep problems. It is caused by lack of expression of the UBE3A gene on the maternal chromosome 15q11-q13. Although part of the diagnostic description, 'sleep problems' are not well characterized. A pattern emerges from the available reports. It includes reduced total sleep time, increased sleep onset latency, disrupted sleep architecture with frequent nocturnal awakenings, reduced rapid eye movement (REM) sleep and periodic leg movements. Poor sleep does not significantly interfere with daytime alertness and sleep problems commonly diminish by late childhood, with continuing improvement through adolescence and adulthood. Sleep problems in Angelman syndrome reflect abnormal neurodevelopmental functioning presumably involving dysregulation of GABA-mediated inhibitory influences in thalamocortical interactions. Management may be difficult, particularly in young children; it primarily involves behavioral approaches, though pharmacological treatment may be required. The relationship between sleep and seizure disorder, and between sleep and learning raises critical questions, but more studies are needed to address these relationships adequately.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Pelc K,Cheron G,Boyd SG,Dan Bdoi
10.1016/j.sleep.2007.07.001subject
Has Abstractpub_date
2008-05-01 00:00:00pages
434-41issue
4eissn
1389-9457issn
1878-5506pii
S1389-9457(07)00254-7journal_volume
9pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract：OBJECTIVE:To report our findings from a sample of narcoleptic children and adolescents evaluated in our unit from 1988 to 2005. PATIENTS AND METHODS:The sample was composed of nine children (5 boys) with a mean age of 14.5 years at diagnosis. The protocol included the following: Epworth, Ullanlinna narcolepsy scale, a...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.02.017
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND AND PURPOSES:To report the neurophysiological features of a patient with alternating leg muscle activation (ALMA) during sleep, a quickly alternating pattern of anterior tibialis activation which might represent transient facilitation of a spinal central pattern generator for locomotion, perhaps due to the s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2005.06.007
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:Few reports on sleep patterns of patients with spinal muscular atrophy type 1 (SMA1) have been published and none on sleep microstructure. The aim of this study was to analyze sleep architecture and microstructure in a group of infants with SMA1, compared with age- and sex-matched controls. METHODS:Twelve SM...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.05.029
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:Studies investigating the effects of subthalamic deep-brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) are limited and report conflicting results, with some describing the emergence of RLS after DBS-STN, while others report postoperative improvement of this disorder. Sev...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.11.020
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:In obstructive sleep apnea syndrome (OSAS), any of the activated neural, vascular, hemodynamic, metabolic, inflammatory, and thrombotic mechanisms may be related to increased cerebrovascular disease and risk of death; however, the possible pathophysiological process between obstructive sleep apnea syndrome an...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.09.020
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence and correlates of help-seeking behaviors for insomnia in Hong Kong Chinese middle-aged adults and their offspring. METHODS:A total of 2231 middle-aged adults (54.2% females, mean age 45.8 years) and 2186 children and adolescents (51.9% females, mean age 13.4 years) completed a qu...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.01.006
更新日期：2016-05-01 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) may offer a reliable means to characterize significant pathophysiologic and neurochemical aspects of restless legs syndrome (RLS). Namely, TMS has revealed specific patterns of changes in cortical excitability and plasticity, in particular dysfunctional inhibitory mechanisms and...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2019.12.009
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:It is now recognized that the vast majority of individuals with typical RBD will develop a synucleinopathy; usually 11-16 years after symptom onset. Parasomnia Overlap Disorder (POD) with adolescent-onset dream enactment behavior with phenoconversion to neurodegenerative disease after a long latency has not ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.01.041
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:The aims of this study were to compare compliance to treatment with fixed CPAP and with autoCPAP, subjective preference for type of CPAP treatment, and factors associated to preference for autoCPAP in patients with OSAS. PATIENTS AND METHODS:Twenty-two subjects were studied in a randomized, single blind cro...
journal_title：Sleep medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.sleep.2003.09.011
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Sleep is vital for adolescent functioning. Those with optimal sleep duration have shown improved capacity to learn and decreased rate of motor vehicle accidents. This study explored the influence of numerous protective and risk factors on adolescents' school night sleep (bedtime, sleep latency, total sleep t...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.07.007
更新日期：2016-10-01 00:00:00
abstract：:Sleep is important for optimal cognitive functioning across the lifespan. Among older adults (≥55 years), self-reported short and long sleep durations have been repeatedly, albeit inconsistently, reported to elevate the risk for poor cognitive function. This meta-analytic review quantitatively summarizes the risk for ...
journal_title：Sleep medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.sleep.2015.08.021
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:We investigated the frequency of restless legs syndrome (RLS) and sleep disturbance in spinocerebellar ataxia type 6 (SCA6). PATIENTS AND METHODS:Five patients out of three multigenerational SCA6 families underwent a standardized investigation protocol including clinical interview for RLS, neuro...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.03.013
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:Pulse wave attenuation, which occurs in association with obstructive sleep apnea (OSA), is sympathetically mediated. We compared the effect of Doxazosin (DO, a peripheral alpha-receptor inhibitor) and Enalapril (EN, an ACE inhibitor) on digital vasoconstriction and nocturnal blood pressure (BP) in hypertensiv...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2009.10.004
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Poor sleep is known to cause detrimental effects on the course of diverse psychiatric disorders and is a putative risk factor for hostility and aggression. Thus, sleep may be crucial in forensic psychiatric practice. However, little is known about the prevalence of sleep disturbances in these complex psychiat...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.03.008
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:The present study was conducted to clarify the prevalence of the use of alcohol and hypnotic medication as sleep aids, and associated factors, in the general population in Japan. METHODS:The survey was conducted in June 2000, using self-administered questionnaires, targeting a population that was selected ra...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.10.009
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:Later school start times for adolescents have been implemented in the US and associated benefits found, although no randomised controlled trials (RCT) have been undertaken. The objective of this study was to evaluate the impact of two school interventions in the UK, a delayed start time and a sleep education ...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2018.10.021
更新日期：2019-08-01 00:00:00
abstract：:Poor sleep quality is very common among pregnant women. Gestational diabetes mellitus (GDM) has been related to various adverse maternal and neonatal outcomes. The aim of this systematic review was to examine the association between poor sleep quality and gestational diabetes risk. Following the Preferred Reporting It...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2019.11.1246
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) is more prevalent in stroke patients than age- and sex-matched controls, but the relationship between SDB and functional outcome of stroke patients is unclear. The aim of our study was to determine the prevalence of SDB in ischemic stroke and its influence on func...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.08.006
更新日期：2009-08-01 00:00:00
abstract：:Sleep-related eating disorder (SRED) is characterized by nocturnal partial arousals associated with compulsive consumption of food and altered levels of consciousness. Reports of an increased incidence of SRED in relatives of affected individuals suggest a genetic predisposition. We report a woman with SRED whose frat...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(02)00137-5
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To document and provide a micro analysis of the relationship between insomnia and health problems, health-care use, absenteeism, productivity and accidents. PARTICIPANTS AND METHODS:A population-based sample of 953 French-speaking adults from Québec, Canada. Participants were categorized as havi...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.04.005
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To evaluate the test-to-test variability of the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS). PATIENTS AND METHODS:Twenty patients with primary RLS (12 men and eight women; age: 53.3+/-11.3 years) were selected for the study. We compared the results of two SI...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.02.007
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Studies examining the impact of daytime preoccupations with sleep are rare. The aim of the present study was to determine whether daytime preoccupations mediate the relationship between anxiety and attributions for poor sleep within older adults. METHOD:A cross-sectional study examined the media...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.08.011
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:Machado-Joseph disease (MJD) is a neurodegenerative disease which usually presents several clinical findings including cerebellar ataxia and other extracerebellar features, such as Parkinsonism, dystonia, peripheral neuropathy, and lower motor neuron disease. Some data have demonstrated a high frequency of sl...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.09.025
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Children's sleep problems are associated with poorer student functioning in the school environment, including impairment in peer relationships; yet, no studies have examined sleep functioning in relation to the student-teacher relationship. The objective of this study was to examine whether child-rated total ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.12.001
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Using transcranial B-mode sonography (TCS), the first morphological marker for restless legs syndrome (RLS), hypoechogenicity of the substantia nigra (SN) has been found. The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to i...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2007.09.001
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Infancy is a period of rapid development when the quality of caregiving behavior may be particularly consequential for children's long-term functioning. During this critical period for caregiving behavior, parents experience changes in their sleep that may affect their ability to provide sensitive ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.07.017
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:To explore the correlates of nocturnal sleep duration, nocturnal sleep variability, and nocturnal sleep problems in a sample of Australian toddlers. METHODS:Participants were 173 toddlers (average age 19.7 ± 4.1 months) from the GET UP! STUDY:Nocturnal sleep duration, nocturnal sleep variability, nap(s) and...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2018.08.035
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVES:Although sleep disorders have been reported to affect more than half of adults with attention-deficit/hyperactivity disorder (ADHD), the association between sleep and ADHD is poorly understood. The aims of our study were to investigate sleep-related variables in adults with ADHD and to assess if any differen...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2013.03.003
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality which may be mediated by increased arterial stiffness and endothelial dysfunction. Continuous positive airway pressure (CPAP) therapy improves excessive daytime somnolence (EDS), but its effect on vascular funct...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2013.08.786
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:Adolescents are predisposed to short sleep duration and irregular sleep patterns due to certain host characteristics (e.g., age, pubertal status, gender, ethnicity, socioeconomic class, and neighborhood distress) and health-related variables (e.g., ADHD, asthma, birth weight, and BMI). The aim of the current...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.07.020
更新日期：2011-03-01 00:00:00
