Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen.

abstract：:[3H]Forskolin bound to high- and low-affinity sites in the rat brain. The high-affinity site was discretely located, with highest densities in the striatum, nucleus accumbens, olfactory tubercule, substantia nigra, hippocampus, and the molecular layers of the cerebellum. This site did not correlate well with the distr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poat JA,Cripps HE,Iversen LL

更新日期：1988-05-01 00:00:00

abstract：:If X(1), X(2),... are independent random variables with zero expectation and finite variances, the cumulative sums S(n) are, on the average, of the order of magnitude S(n), where S(n) (2) = E(S(n) (2)). The occasional maxima of the ratios S(n)/S(n) are surprisingly large and the problem is to estimate the extent of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feller W

更新日期：1969-07-01 00:00:00

abstract：:AMP deaminase (adenylate deaminase; AMP aminohydrolase, EC 3.5.4.6), a large flat tetrameric enzyme found in skeletal muscle, binds strongly and specifically to the subfragment-2 region of rabbit skeletal muscle myosin. This allows its use as a structural probe in myosin and myosin rod aggregation studies. When mixed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koretz JF

更新日期：1982-10-01 00:00:00

abstract：:We show that endemic (eBL), sporadic (sBL), and acquired immunodeficiency syndrome-associated (AIDS-BL) forms of Burkitt lymphoma (BL) carrying t(8;14) chromosomal translocations display different breakpoints within the immunoglobulin heavy-chain locus (IGH) on chromosome 14. In sBL (7 out of 11) and AIDS-BL (5 out of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neri A,Barriga F,Knowles DM,Magrath IT,Dalla-Favera R

更新日期：1988-04-01 00:00:00

abstract：:The bacterial transposon Tn7 encodes two distinct but overlapping transposition pathways. tnsABC + tnsD promote transposition to a specific site, attTn7, while tnsABC + tnsE promote transposition to many other sites unrelated to attTn7. We have identified a tnsD-dependent DNA binding activity that specifically recogni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waddell CS,Craig NL

更新日期：1989-06-01 00:00:00

abstract：:The distribution of wealth in the United States and countries around the world is highly skewed. How does visible economic inequality affect well-off individuals' support for redistribution? Using a placebo-controlled field experiment, I randomize the presence of poverty-stricken people in public spaces frequented by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sands ML

更新日期：2017-01-24 00:00:00

abstract：:The notion of stability of a local ring arises naturally in investigating completed moduli spaces via geometric invariant theory. A scheme corresponding to a boundary point of a moduli space of nonsingular varieties cannot have unstable singular points. This paper reports some results concerning the stability of surfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah J

更新日期：1978-09-01 00:00:00

abstract：:The role of anti-peripheral nerve myelin antibody (anti-PNM Ab) in the pathogenesis of acquired demyelination of peripheral nerve is unclear, in part, due to the poor correlation between antibody and disease activity. Previous studies show that only 27-50% of patients with acute demyelinating neuropathy or Guillain-Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koski CL,Humphrey R,Shin ML

更新日期：1985-02-01 00:00:00

abstract：:Gene therapy of the brain is hindered by the presence of the blood-brain barrier (BBB), which prevents the brain uptake of bloodborne gene formulations. Exogenous genes have been expressed in the brain after invasive routes of administration, such as craniotomy or intracarotid arterial infusion of noxious agents causi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi N,Pardridge WM

更新日期：2000-06-20 00:00:00

abstract：:Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-chase experiments, tog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng AC,Miyake T,Yokoe S,Zhang L,Rezende LM Jr,Sharma P,MacLennan DH,Liu PP,Gramolini AO

更新日期：2015-06-09 00:00:00

abstract：:Plant morphogenesis requires coordinated cytoplasmic growth, oriented cell wall extension, and cell cycle progression, but it is debated which of these processes are primary drivers for tissue growth and directly targeted by developmental genes. Here, we used ChIP high-throughput sequencing combined with transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiessl K,Muiño JM,Sablowski R

更新日期：2014-02-18 00:00:00

abstract：:The role of GATA4 during the earliest stages of cardiogenesis has not been defined because Gata4 knockout embryos suffer an early developmental arrest caused by deficiencies in extraembryonic visceral endoderm function. We have used tetraploid embryo complementation to rescue these defects and generated clonal embryon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watt AJ,Battle MA,Li J,Duncan SA

更新日期：2004-08-24 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls the degradation of substrate proteins at mitotic exit and throughout the G1 phase. We have identified an APC/C substrate and cell cycle-regulated protein, KIAA0101/PAF15. PAF15 protein levels peak in the G2/M p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emanuele MJ,Ciccia A,Elia AE,Elledge SJ

更新日期：2011-06-14 00:00:00

abstract：:Hearing is one of the last sensory modalities to be subjected to genetic analysis in Drosophila melanogaster. We describe a behavioral assay for auditory function involving courtship among groups of males triggered by the pulse component of the courtship song. In a mutagenesis screen for mutations that disrupt the aud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eberl DF,Duyk GM,Perrimon N

更新日期：1997-12-23 00:00:00

abstract：:The proliferating cell nuclear antigen (PCNA) acts as a processivity factor for replicative DNA polymerases and is essential for DNA replication. In vitro studies have suggested a role for PCNA-in the repair synthesis step of nucleotide excision repair, and PCNA interacts with the cyclin-dependent kinase inhibitor p21...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres-Ramos CA,Yoder BL,Burgers PM,Prakash S,Prakash L

更新日期：1996-09-03 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae, and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, in a nonstructural protein (nsp) that is released from polyprotein 1ab by the viral main protease (Mpro). Previously, self-GMPylation/UMPylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slanina H,Madhugiri R,Bylapudi G,Schultheiß K,Karl N,Gulyaeva A,Gorbalenya AE,Linne U,Ziebuhr J

更新日期：2021-02-09 00:00:00

abstract：:Some strains of Bradyrhizobium japonicum produce rhizobitoxine, a phytotoxin that causes foliar chlorosis on susceptible host plants. We have previously obtained Tn5-induced rhizobitoxine null mutants of B. japonicum. DNA sequence analysis of the region surrounding two Tn5 insertions identifies two overlapping open re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan X,Zhang C,Peters NK

更新日期：1993-04-01 00:00:00

abstract：:Aging and disease processes may be due to deleterious and irreversible changes produced by free radical reactions. The enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) performs a protective function by scavenging superoxide radicals. The Cu-Zn SOD gene (Sod) cloned...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto NO,Hayashi S,Tener GM

更新日期：1990-06-01 00:00:00

abstract：:These experiments investigate the capacity of thalamic and cortical structures in a sensory system to process information of a modality normally associated with another system. Retinal ganglion cells in newborn Syrian hamsters were made to project permanently to the main thalamic somatosensory (ventrobasal) nucleus. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Métin C,Frost DO

更新日期：1989-01-01 00:00:00

abstract：:Here, we describe the identification and characterization of a nuclear body (matrix-associated deacetylase body) whose formation and integrity depend on deacetylase activity. Typically, there are 20-40 0.5-microM bodies per nucleus, although the size and number can vary substantially. The structure appears to contain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Downes M,Ordentlich P,Kao HY,Alvarez JG,Evans RM

更新日期：2000-09-12 00:00:00

abstract：:In this study we examine how the introduction of a reference lottery with nonrandom outcomes alters the way in which choices among pairs of lotteries are made, even if it does not alter the choices. We use different domains (some of the lotteries produce gains, other losses) and different contexts (one member of the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickhaut J,McCabe K,Nagode JC,Rustichini A,Smith K,Pardo JV

更新日期：2003-03-18 00:00:00

abstract：:We describe a method based on a phagemid vector with helper phage rescue for the construction and rapid analysis of combinatorial antibody Fab libraries. This approach should allow the generation and selection of many monoclonal antibodies. Antibody genes are expressed in concert with phage morphogenesis, thereby allo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang AS,Barbas CF,Janda KD,Benkovic SJ,Lerner RA

更新日期：1991-05-15 00:00:00

abstract：:Citizenship endows legal protections and is associated with economic and social gains for immigrants and their communities. In the United States, however, naturalization rates are relatively low. Yet we lack reliable knowledge as to what constrains immigrants from applying. Drawing on data from a public/private natura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hainmueller J,Lawrence D,Gest J,Hotard M,Koslowski R,Laitin DD

更新日期：2018-01-30 00:00:00

abstract：:DNA containing 5-azacytosine (azaC) has previously been shown to be a potent inhibitor of DNA-cytosine methyltransferases. In this report, we describe experiments which demonstrate that azaC-DNA forms a covalent complex with Hpa II methylase, a bacterial enzyme that methylates the internal C of C-C-G-G sequences. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santi DV,Norment A,Garrett CE

更新日期：1984-11-01 00:00:00

abstract：:The mitochondrial DNA polymerase from Drosophila embryos lacks dNTP turnover activity. However, a potent 3'----5' exonuclease activity can be detected by a specific assay in which the exonuclease excises mispaired nucleotides at the 3' termini of primed synthetic and natural DNA templates. The excision of a mispaired ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaguni LS,Olson MW

更新日期：1989-09-01 00:00:00

abstract：:The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torbati M,Lele TP,Agrawal A

更新日期：2016-10-04 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:Deregulated production of nitric oxide (NO) has been implicated in the development of certain human diseases, including cancer. We sought to assess the damaging potential of NO produced under long-term conditions through the development of a suitable model cell culture system. In this study, we report that when murine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang JC,Wogan GN

更新日期：1997-10-28 00:00:00

abstract：:In a study of autonomic reflexes it was found that some produce a generalized, bilaterally uniform response whereas others have an asymmetric or laterality of action. Recordings from vertebral nerve fibers (mainly vasoconstrictors to forelimb muscles), right and left cardiac sympathetics, and renal nerves show that ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kollai M,Koizumi K,Brooks CM

更新日期：1978-10-01 00:00:00

abstract：:Functional imaging of the human brain is an increasingly important technique for clinical and cognitive neuroscience research, with functional MRI (fMRI) of the blood oxygen level-dependent (BOLD) response and electroencephalography or magnetoencephalography (MEG) recordings of neural oscillations being 2 of the most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muthukumaraswamy SD,Edden RA,Jones DK,Swettenham JB,Singh KD

更新日期：2009-05-19 00:00:00