Abstract：
:Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of "receptor reserve", also known as "spare receptors". This kind of receptors allow agonists to achieve their maximal effect without occupying all of the relevant cell receptors. In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease or some kinds of neurocardiogenic syncopes. In both cases, the presence of spare receptors appears to be an attempt to overcome a weak interaction between adenosine and its receptors. The identification of adenosine spare receptors in cardiovascular disorders may be helpful for diagnostic purposes.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Fenouillet E,Mottola G,Kipson N,Paganelli F,Guieu R,Ruf Jdoi
10.3390/ijms20235964subject
Has Abstractpub_date
2019-11-27 00:00:00issue
23issn
1422-0067pii
ijms20235964journal_volume
20pub_type
杂志文章,评审abstract：:We have recently found that diabetes-induced premature senescence of retinal endothelial cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase enzyme arginase 1 (A1). Here, we used genetic strategies to determine the specific involvement of A1 in diabetes-induced endothelial cell senescence...
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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