Evaluating triptorelin as a treatment option for breast cancer.

abstract：INTRODUCTION:Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma. Additional drugs include leukotriene-receptor antagonists, slow-release theophylline and the long-acting muscarini...

journal_title：Expert opinion on pharmacotherapy

authors： Thomson NC

更新日期：2017-02-01 00:00:00

abstract：:Despite the revolutionary introduction of antibiotic therapy in the post-World War II era, primary care physicians continue to struggle with the issue of optimal treatment strategies for bacterial infection and the growing problem of antimicrobial resistance. The aggressive use of potent agents as first-line therapy m...

journal_title：Expert opinion on pharmacotherapy

authors： Nicolau DP

更新日期：2004-02-01 00:00:00

abstract：:Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify assoc...

journal_title：Expert opinion on pharmacotherapy

authors： Stamer UM,Stüber F

更新日期：2007-10-01 00:00:00

abstract：:Cervical dystonia (CD) manifests clinically through involuntary spasms of neck muscles, producing abnormal head and neck movements and postures, which is often associated with pain. CD is the most common form of focal dystonia presenting to movement disorders clinics. Chemodenervation with botulinum toxin (BTX) has be...

journal_title：Expert opinion on pharmacotherapy

authors： Tintner R,Jankovic J

更新日期：2001-12-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Prostate cancer is a common cancer and the role of adjuvant medical therapy continues to be investigated. An understanding of the use of adjuvant medical therapy is essential for the appropriate care of prostate cancer patients, especially for those with locally advanced or high-risk disease. A...

journal_title：Expert opinion on pharmacotherapy

authors： Sumey C,Flaig TW

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The management of thyroid cancer is difficult because the tumors comprise a wide range of biologic behaviors, from small papillary thyroid microcarcinomas that pose little or no threat to survival for the patient, to anaplastic thyroid cancers that are arguably the most lethal tumor. Although it may be diffi...

journal_title：Expert opinion on pharmacotherapy

authors： Sipos JA,Mazzaferri EL

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Only 40-60% of obsessive-compulsive patients respond to first line treatments, such as selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy. Several second-line treatments have been investigated in the last two decades, and most of them seem to work, at least in a subset of pati...

journal_title：Expert opinion on pharmacotherapy

authors： Grassi G,Pallanti S

更新日期：2018-10-01 00:00:00

abstract：:Introduction: The increasing prevalence of comorbid depression and diabetes exerts a heavy burden on global health. Co-occurrence of depression and diabetes is common, affecting 14% to 35.8% of patients with diabetes, leading to a higher mortality and morbidity rate, more micro- and macro-vascular diseases and more co...

journal_title：Expert opinion on pharmacotherapy

authors： Li HQ,Chi S,Dong Q,Yu JT

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Status epilepticus (SE) is a common neurological and medical emergency. It has high mortality and morbidity rates, which typically correlate with seizure semiology and duration; therefore, prompt and proper pharmacological intervention is paramount. In a pre-hospital setting, establishing venous access can...

journal_title：Expert opinion on pharmacotherapy

authors： Riva A,Iapadre G,Grasso EA,Balagura G,Striano P,Verrotti A

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:The introduction of novel agents has significantly improved multiple myeloma (MM) patient outcome during the last two decades. MM received the most drug approvals for any one malignancy during this time period, both in the United States as well as in Europe. Areas covered: Proteasome inhibitors, immunomodu...

journal_title：Expert opinion on pharmacotherapy

authors： Podar K,Pecherstorfer M

更新日期：2017-08-01 00:00:00

abstract：:Seborrhoeic dermatitis (SD) is a chronic, inflammatory skin disorder, affecting areas of the head and body where sebaceous glands are most prominent and active. The disorder commonly affects hair-bearing areas of the head, including the scalp. Involvement on the face is usually limited to the hairline, eyebrows, nasol...

journal_title：Expert opinion on pharmacotherapy

authors： Faergemann J,Borgers M,Degreef H

更新日期：2007-06-01 00:00:00

abstract：:The burden of insomnia has had a significant effect not only on the socioeconomic matrix, but also the medical terrain, as signified by the increased morbidity and mortality of its associated psychiatric and organic sequelae. To this end, a plethora of pharmacotherapeutic agents have been recently introduced that addr...

journal_title：Expert opinion on pharmacotherapy

authors： Navab P,Guilleminault C

更新日期：2006-09-01 00:00:00

abstract：:Elevated blood pressure levels are highly prevalent and are a major reason for cardiovascular events and thus place a significant financial burden on healthcare systems worldwide. Guidelines recommend five first-line anti-hypertensive drug classes, but compelling indications may indicate favoring one drug class over a...

journal_title：Expert opinion on pharmacotherapy

authors： Bramlage P,Durand-Zaleski I,Desai N,Pirk O,Hacker C

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:For more than two decades, lowering levels of low-density lipoprotein cholesterol has formed the cornerstone of management of patients with atherosclerotic cardiovascular disease. The substantial residual risk of clinical events in patients treated with statin therapy highlights the need to develop more ef...

journal_title：Expert opinion on pharmacotherapy

authors： Nicholls SJ,Pisaniello AD,Kataoka Y,Puri R

更新日期：2014-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:It is very rare for patients with bipolar disorder to have a single episode of mania or depression over a lifetime and the vast majority of these individuals need long-term prophylactic/maintenance treatment. However, treatment nonadherence is a major issue for close to half of subjects with bip...

journal_title：Expert opinion on pharmacotherapy

authors： Fagiolini A,Casamassima F,Mostacciuolo W,Forgione R,Goracci A,Goldstein BI

更新日期：2010-07-01 00:00:00

abstract：:Actinic keratosis (AK) and basal cell carcinoma (BCC) are precancerous and cancerous skin lesions that should be treated especially when multiple or in cosmetically important areas. Apart from 5% 5-fluorouracil topical cream, which some feel is the gold standard topical treatment for AK, several invasive treatment mod...

journal_title：Expert opinion on pharmacotherapy

authors： Papadavid E,Stratigos AJ,Falagas ME

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:Graves' hyperthyroidism is associated with significant morbidity and mortality risk. The thionamides, methimazole, its pro-drug derivative carbimazole, and propylthiouracil, remain a cornerstone of management. Yet despite decades of use, optimal strategies for maximising treatment response and curtailing a...

journal_title：Expert opinion on pharmacotherapy

authors： Okosieme OE,Lazarus JH

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Tamoxifen is the established adjuvant treatment for postmenopausal women with hormone-sensitive breast cancer. OBJECTIVE:To determine whether the aromatase inhibitor anastrozole should replace tamoxifen as the adjuvant treatment in this cancer. METHODS:Two recent trials of anastrozole and tamoxifen as adju...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2008-06-01 00:00:00

abstract：:Amifostine (Ethyoltrade mark, Alza Pharmaceuticals) is an inorganic thiophosphate cytoprotective agent known chemically as ethanethiol, 2-[3- aminopropyl)amino]dihydrogen phosphate. It is a prodrug of free thiol (WR-1065) that may act as a scavenger of free radicals generated in tissues exposed to cytotoxic drugs and ...

journal_title：Expert opinion on pharmacotherapy

authors： Santini V

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Etravirine is the first non-nucleoside reverse transcriptase inhibitor (NNRTI) to be active against human immunodeficiency virus with NNRTI mutations. OBJECTIVE:To understand the unique features of etravirine and to evaluate its safety, efficacy, and optimal use. METHODS:The structure and the mechanism of ...

journal_title：Expert opinion on pharmacotherapy

authors： Jayaweera DT,Espinoza L,Castro J

更新日期：2008-12-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare disease characterized by the accumulation of clonal dendritic cells in different organs. Most recent findings (e.g., activating BRAF mutations) favor the hypothesis that LCH may represent a neoplasm with varying behavior, but the ultimate pathogenesis remains to be uncover...

journal_title：Expert opinion on pharmacotherapy

authors： Minkov M

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide. Although advanced NSCLC is still incurable, various anti-neoplastic agents have become available for the treatment of this disease. Pemetrexed , a multi-target folate antagonist, has improved the survival of non-squamous...

journal_title：Expert opinion on pharmacotherapy

authors： Genova C,Rijavec E,Truini A,Coco S,Sini C,Barletta G,Dal Bello MG,Alama A,Savarino G,Pronzato P,Boccardo F,Grossi F

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Since the recognition of inherited sodium (Na(+)) channel disease, the cardiac Na(+) channel has been extensively studied. Both loss-of-function and gain-of-function mutations of the cardiac Na(+) channel are associated with cardiac arrhythmia and sudden cardiac death. Pathophysiological mechanisms that ma...

journal_title：Expert opinion on pharmacotherapy

authors： van Hoeijen DA,Blom MT,Tan HL

更新日期：2014-09-01 00:00:00

abstract：:Thirty to forty percent of patients with idiopathic membranous nephropathy have persistent heavy proteinuria and may progress to end-stage kidney disease in 5 - 15 years. The ideal treatment for these patients is a matter of debate. Several nonspecific immunosuppressive regimens have been suggested with the aim of red...

journal_title：Expert opinion on pharmacotherapy

authors： Ruggenenti P,Cravedi P,Remuzzi G

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:The study investigated the efficacy and tolerability of teneligliptin co-administered to patients with type 2 diabetes mellitus (T2DM) who were inadequately controlled by stable metformin monotherapy ≥ 1000 mg/day. METHODS:A total of 447 patients from 55 European centers who completed a 14-day screening and ...

journal_title：Expert opinion on pharmacotherapy

authors： Bryson A,Jennings PE,Deak L,Paveliu FS,Lawson M

更新日期：2016-07-01 00:00:00

abstract：:Anticoagulants are used for the prevention and treatment of venous thromboembolism and for the secondary prevention of stroke and myocardial infarction. The list of available anticoagulants includes unfractionated heparin, low molecular weight heparins, fondaparinux, warfarin and the direct thrombin inhibitors. Numero...

journal_title：Expert opinion on pharmacotherapy

authors： Hawkins D,Huston SA

更新日期：2006-06-01 00:00:00

abstract：INTRODUCTION:Diabetic foot ulcers, especially when they become infected, are a leading cause of morbidity and may lead to severe consequences, such as amputation. Optimal treatment of these diabetic foot problems usually requires a multidisciplinary approach, typically including wound debridement, pressure off-loading,...

journal_title：Expert opinion on pharmacotherapy

authors： Abbas M,Uçkay I,Lipsky BA

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common immune-mediated disorder that in 70% of cases appears in mild or mild-to-moderate form. Psoriasis is usually treated with topical medications and/or phototherapy with variable efficacy in controlling the disease. AREAS COVERED:For the past three decades, research has been focused on ...

journal_title：Expert opinion on pharmacotherapy

authors： Chiricozzi A,Pitocco R,Saraceno R,Nistico SP,Giunta A,Chimenti S

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) can spontaneously improve during pregnancy. However, a considerable proportion of patients can experience a flare and high disease activity has been associated with an increased risk of adverse pregnancy outcome. Thus, the treatment of RA in pregnant women should be selected takin...

journal_title：Expert opinion on pharmacotherapy

authors： Gerosa M,Schioppo T,Meroni PL

更新日期：2016-08-01 00:00:00

abstract：:Hydrocephalus is an excess accumulation of cerebrospinal fluid in or around the brain that can be produced by a broad spectrum of disorders. It can develop at any age and its incidence is increasing, both in infants and adults. Although the standard treatment of hydrocephalus is cerebrospinal fluid shunting, there are...

journal_title：Expert opinion on pharmacotherapy

authors： Poca MA,Sahuquillo J

更新日期：2005-08-01 00:00:00