Amifostine: chemotherapeutic and radiotherapeutic protective effects.

abstract：:A systemic and endemic emerging mycosis in Latin America, paracoccidioidomycosis, is characterised by its chronicity and by the severity of the disseminated form in healthy individuals, as well as in immunocompromised individuals co-infected with HIV, resulting, in the latter, in a mortality rate in the range of 30 - ...

journal_title：Expert opinion on pharmacotherapy

authors： Yasuda MA

更新日期：2005-03-01 00:00:00

abstract：:Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify assoc...

journal_title：Expert opinion on pharmacotherapy

authors： Stamer UM,Stüber F

更新日期：2007-10-01 00:00:00

abstract：:Itraconazole is a broad spectrum triazole antifungal agent. It has favourable pharmacodynamic and pharmacokinetic profiles and is available as both oral and i.v. formulations. Over the last two decades, clinical and animal infection studies have demonstrated the efficacy of itraconazole in a wide range of superficial ...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Arrese JE,Piérard-Franchimont C

更新日期：2000-01-01 00:00:00

abstract：:Non-motor symptoms may considerably reduce parkinsonian quality of life, particularly in advanced stages of the disease. Autonomic features, such as seborrhoea, hyperhidrosis, orthostatic hypotension, excessive salivation, bladder dysfunction and GI disturbances, and neuropsychiatric symptoms, such as depression, slee...

journal_title：Expert opinion on pharmacotherapy

authors： Müller T

更新日期：2002-04-01 00:00:00

abstract：:Ovarian cancer is the fifth leading cause of cancer deaths in women. The majority of patients present with advanced disease and relapse after first-line platinum-based chemotherapy; therefore, many proceed to treatment with salvage chemotherapy. Currently available treatment options are generally no longer curative in...

journal_title：Expert opinion on pharmacotherapy

authors： Ahmad T,Gore M

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. AREAS COVERED:Herein, the authors address the eff...

journal_title：Expert opinion on pharmacotherapy

authors： Dempsey JL,Johns A,Rosko AE,Lazarus HM

更新日期：2019-05-01 00:00:00

abstract：:Multiple approaches to enhancing antidepressant treatment response in bipolar depression are available and should, in many instances, be explored despite a lack of definitive controlled trial literature supporting their efficacy. Given that the morbidity of depression is three times greater than mania in bipolar illne...

journal_title：Expert opinion on pharmacotherapy

authors： Post RM

更新日期：2005-04-01 00:00:00

abstract：:Cronkhite-Canada syndrome (CCS) is a rare, non-inherited gastrointestinal polyposis syndrome associated with characteristic ectodermal abnormalities. A number of potentially life-threatening complications including malnutrition, gastrointestinal bleeding and infection may occur in affected patients and CCS is fatal in...

journal_title：Expert opinion on pharmacotherapy

authors： Ward EM,Wolfsen HC

更新日期：2003-03-01 00:00:00

abstract：:The burden of insomnia has had a significant effect not only on the socioeconomic matrix, but also the medical terrain, as signified by the increased morbidity and mortality of its associated psychiatric and organic sequelae. To this end, a plethora of pharmacotherapeutic agents have been recently introduced that addr...

journal_title：Expert opinion on pharmacotherapy

authors： Navab P,Guilleminault C

更新日期：2006-09-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Hypertension is a major independent risk factor for kidney disease and for faster renal function loss. Choice of antihypertensive strategies with highest nephroprotective effect is crucial to prevent or reverse progression to end stage renal disease (ESRD). AREAS COVERED IN THIS REVIEW:The pres...

journal_title：Expert opinion on pharmacotherapy

authors： Cravedi P,Ruggenenti P,Remuzzi G

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Gastritis is a broad term, which is used for different conditions by clinicians, endoscopists and pathologists. Classification strategies have led to more congruence between specialists. The histological evaluation of the gastric mucosa is mandatory for diagnosing and classifying gastritis. Main aetiologic...

journal_title：Expert opinion on pharmacotherapy

authors： den Hollander WJ,Kuipers EJ

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Atherosclerosis is frequently caused by clot blockage of the coronary or peripheral arteries, and may lead to myocardial infarction (MI) or peripheral arterial disease (PAD). Despite advancements in management of atherosclerosis, mortality and ischemic rates remain high. Vorapaxar is a protease activated r...

journal_title：Expert opinion on pharmacotherapy

authors： Wang A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:This study examined the effects of short-term administration of the sodium glucose cotransporter 2 (SGLT-2) inhibitor, dapagliflozin, on visceral fat area (VFA) in Japanese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:In this randomized, crossover, controlled clinical trial, overweight patient...

journal_title：Expert opinion on pharmacotherapy

authors： Kato K,Suzuki K,Aoki C,Sagara M,Niitani T,Wakamatsu S,Yanagi K,Aso Y

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular degeneration (AMD), all blinding diseases that lack effective treatment options. AREAS COVERED:...

journal_title：Expert opinion on pharmacotherapy

authors： Hussain RM,Gregori NZ,Ciulla TA,Lam BL

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of the central nervous system involving inflammation, chronic demyelination and axonal loss. MS affects more than 2 million people worldwide. AREAS COVERED:This article aims to summarize the findings from two pivotal 2-year, randomized, do...

journal_title：Expert opinion on pharmacotherapy

authors： Havrdova E,Hutchinson M,Kurukulasuriya NC,Raghupathi K,Sweetser MT,Dawson KT,Gold R

更新日期：2013-10-01 00:00:00

abstract：:In the recent years, advances in the treatment of chronic hepatitis B and C have shown that newer, more expensive therapy may result in higher sustained viral response rates. In light of this, the pertinent question for healthcare decision-makers centres around whether this increase in efficacy 'justifies' the additio...

journal_title：Expert opinion on pharmacotherapy

authors： Younossi ZM,Temple ME,Shermock KM

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Fesoterodine is a newly approved drug for the treatment of overactive bladder syndrome. OBJECTIVE:The aim of this study was to review the preclinical and clinical data on fesoterodine. METHODS:The study involved a search of the Medline database and the proceedings volumes of urological congresses. RESULTS...

journal_title：Expert opinion on pharmacotherapy

authors： Michel MC

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease (AD)-related epileptic comorbidity is now well documented and appears to have been previously underestimated. Prescribing antiepileptic drugs (AEDs) in AD patients aims at preventing seizure-related morbi-mortality and the occurrence of deleterious status epilepticus. At the earlier sta...

journal_title：Expert opinion on pharmacotherapy

authors： Cretin B

更新日期：2018-08-01 00:00:00

abstract：:alpha-adrenoceptor antagonists have traditionally been used in the treatment of hypertension but in recent years they have become increasingly common in the treatment of benign prostatic enlargement (BPE), where they reduce the 'dynamic' component of bladder outlet obstruction and appear to have additional actions to ...

journal_title：Expert opinion on pharmacotherapy

authors： Chess-Williams R

更新日期：2002-02-01 00:00:00

abstract：:Recognising the value added by economic evaluations of clinical trials and the interaction of clinical, humanistic and economic end points, the Radiation Therapy Oncology Group (RTOG) has developed an Outcomes Model that guides the comprehensive assessment of this triad of end points. This paper will focus on the econ...

journal_title：Expert opinion on pharmacotherapy

authors： Konski A,Watkins-Bruner D,RTOG (Radiation Therapy Oncology Group) Outcomes Model.

更新日期：2004-03-01 00:00:00

abstract：:Negative symptoms are core features of schizophrenia that respond poorly to first-generation antipsychotics and present a major obstacle in rehabilitation. Patients may be somewhat more responsive to clozapine and second-generation antipsychotics but even then, considerable impairment remains. This paper reviews the u...

journal_title：Expert opinion on pharmacotherapy

authors： Silver H

更新日期：2004-10-01 00:00:00

abstract：INTRODUCTION:Allergic rhinitis is a common condition with increasing prevalence and is associated with several comorbid disorders such as bronchial asthma and atopic dermatitis. If allergen avoidance is not possible, allergen-specific immunotherapy is the only causal treatment option. AREAS COVERED:This review focuses...

journal_title：Expert opinion on pharmacotherapy

authors： Klimek L,Sperl A,Becker S,Mösges R,Tomazic PV

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:In 1991, small cell lung cancer (SCLC) was reported as the first tumour type where colony stimulating factor (CSF) support was clinically effective. We reviewed 13 health services research studies that addressed CSF use as supportive care for SCLC. METHODS:Findings from American Society of Clinical Oncology...

journal_title：Expert opinion on pharmacotherapy

authors： Adams JR,Lyman GH,Djubegovic B,Feinglass J,Bennett CL

更新日期：2002-09-01 00:00:00

abstract：INTRODUCTION:Glaucoma is the second leading cause of blindness globally, representing a significant public health concern. More than 60 million people are affected by glaucoma worldwide; as this population ages, the number is expected to increase. Glaucoma is a collection of heterogeneous diseases sharing common clinic...

journal_title：Expert opinion on pharmacotherapy

authors： Konstas AG,Quaranta L,Realini T

更新日期：2012-04-01 00:00:00

abstract：:The American Heart Association annual meeting must be one of the largest scientific gatherings, attracting over 30,000 delegates. The meeting at the end of last year was held in Atlanta, USA, the 2000 meeting will be in New Orleans, USA. The following highlights represent my own interests. ...

journal_title：Expert opinion on pharmacotherapy

authors： Lunnon MW

更新日期：2000-03-01 00:00:00

abstract：:The introduction of steroid therapy by Truelove and Witts in the 1950s revolutionized the treatment of ulcerative colitis. Corticosteroids are potent inhibitors of T-cell activation and proinflammatory cytokines and still represent the mainstay of therapy of patients with ulcerative colitis. About 15% of patients are ...

journal_title：Expert opinion on pharmacotherapy

authors： Bossa F,Colombo E,Andriulli A,Annese V

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:The global epidemic of diabetes has led to an epidemic of diabetes complications. Diabetic neuropathy is the most common microvascular complication, of which diabetic peripheral neuropathy (DPN) and autonomic neuropathy (AN) are the most prevalent, affecting ~50% of patients. DPN results in pain with a poo...

journal_title：Expert opinion on pharmacotherapy

authors： Azmi S,Alam U,Burgess J,Malik RA

更新日期：2021-01-01 00:00:00

abstract：:Vascular injury is a ubiquitous phenomenon which can be both occult (such as with hyperlipidemia) and overt (such as with angioplasty). While the exact pathophysiology differs between acute and chronic atherosclerosis, both lesions can be mechanistically explained by the vasculature's exaggerated response to injury. P...

journal_title：Expert opinion on pharmacotherapy

authors： Selzman CH

更新日期：2001-05-01 00:00:00

abstract：:Introduction: Body dysmorphic disorder is a debilitating disorder that often presents with significant delusionality, low insight, and both medical and psychiatric comorbidities, presenting a challenge for treatment and long-term management. Its typically chronic course requires that therapy be continued indefinitely,...

journal_title：Expert opinion on pharmacotherapy

authors： Dong N,Nezgovorova V,Hong K,Hollander E

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Combination of glibenclamide (glyburide in the U.S.) and metformin hydrochloride simultaneously addresses two different but complimentary mechanisms to improve glycemic control in type 2 diabetes. AREAS COVERED:The pharmacokinetics, efficacy, and side effect profile of the oral combination of glibenclamid...

journal_title：Expert opinion on pharmacotherapy

authors： Lamos EM,Stein SA,Davis SN

更新日期：2012-12-01 00:00:00