The pharmacogenetics of analgesia.

abstract：:Chronic kidney diseases frequently advance to end-stage renal failure, and the number of patients affected is steadily increasing worldwide. At the molecular level, progression of renal insufficiency correlates closely with ongoing pathological matrix protein expansion (i.e., renal fibrosis), in a manner independent o...

journal_title：Expert opinion on pharmacotherapy

authors： Gaedeke J,Neumayer HH,Peters H

更新日期：2006-03-01 00:00:00

abstract：:Seborrhoeic dermatitis (SD) is a chronic, inflammatory skin disorder, affecting areas of the head and body where sebaceous glands are most prominent and active. The disorder commonly affects hair-bearing areas of the head, including the scalp. Involvement on the face is usually limited to the hairline, eyebrows, nasol...

journal_title：Expert opinion on pharmacotherapy

authors： Faergemann J,Borgers M,Degreef H

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of daily sildenafil on levels of soluble molecular markers of endothelial function in men with erectile dysfunction. METHODS:Patients aged >18 years with erectile dysfunction of vascular etiology for >6 months, either alone or in combination with disease states strongly associated w...

journal_title：Expert opinion on pharmacotherapy

authors： Konstantinopoulos A,Giannitsas K,Athanasopoulos A,Spathas D,Perimenis P

更新日期：2009-02-01 00:00:00

abstract：:One vaccine designed to prevent cancer by preventing a precursor infection is already in common use, and at least one more is in the latter stages of clinical development. These vaccines are part of a new era of cancer immunoprophylaxis. Several further vaccines are in preclinical and clinical development, targeted at...

journal_title：Expert opinion on pharmacotherapy

authors： Frazer I

更新日期：2004-12-01 00:00:00

abstract：:Introduction: Insomnia has been implicated in the development, maintenance, worsening, and relapse of alcohol use disorder (AUD).Areas covered: The authors review the possible pharmacological and non-pharmacological treatment options of insomnia for patients with alcohol-use disorder and provide their expert opinion.E...

journal_title：Expert opinion on pharmacotherapy

authors： Geoffroy PA,Lejoyeux M,Rolland B

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Much research has gone into developing medications that can be used to alleviate endometriosis-associated symptoms. In addition to already established medications, a new GnRH antagonist, elagolix, is in development. The novelty of this drug compared to other GnRH antagonists, is its nonpeptide structure, a...

journal_title：Expert opinion on pharmacotherapy

authors： Perricos A,Wenzl R

更新日期：2017-09-01 00:00:00

abstract：:Paracetamol (acetaminophen) is one of the over-the-counter analgesics that is used frequently for the self-management of some of the common disorders. There seems to be two types of relations between paracetamol and asthma - paracetamol intolerance leading to bronchospasm in analgesic-induced asthmatics; and the relat...

journal_title：Expert opinion on pharmacotherapy

authors： Karakaya G,Kalyoncu AF

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Kidney transplantation is the treatment of choice for patients with end-stage renal failure, and their survival after transplantation is gradually improving. Everolimus (EVL) is a mammalian target of rapamycin inhibitor, providing a safe and effective immunosuppressive regime after kidney transplantation. ...

journal_title：Expert opinion on pharmacotherapy

authors： Dantal J

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Osteoporosis is a well-recognized disease with severe consequences if left untreated. The prevention of osteoporosis-associated fractures should include fall prevention, calcium supplementation and life-style advice, as well as pharmacological therapy using agents with proven antifracture efficacy. AREAS ...

journal_title：Expert opinion on pharmacotherapy

authors： Lecart MP,Reginster JY

更新日期：2011-11-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Statins are widely accepted as the drugs of choice for achieving increasingly stringent low-density lipoprotein cholesterol (LDL-C) goals for dyslipidemic patients. However, when making treatment decisions, outcomes data from clinical trials are of greater importance than LDL-C-lowering ability....

journal_title：Expert opinion on pharmacotherapy

authors： Weart CW,Hogan RJ

更新日期：2011-01-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Acute promyelocytic leukemia (APL) represents a paradigm of therapeutic success in clinical hematology. Since the introduction of all-trans-retinoic-acid in the early 1980s, complete remission rates exceed 90% and the cure rate is > 70%. Notwithstanding, various questions concerning the manageme...

journal_title：Expert opinion on pharmacotherapy

authors： Ferrara F

更新日期：2010-03-01 00:00:00

abstract：:Introduction: The current recommendations of chronic obstructive pulmonary disease (COPD) suggest to escalate from inhaled corticosteroid/long-acting β2-adrenoceptor agonist (ICS/LABA) treatment to triple therapy in patients experiencing persistent breathlessness, exercise limitation, or exacerbation. The addition of ...

journal_title：Expert opinion on pharmacotherapy

authors： Ritondo BL,Puxeddu E,Calzetta L,Cazzola M,Rogliani P

更新日期：2020-11-11 00:00:00

abstract：INTRODUCTION:Hepatitis C virus (HCV) therapy continues to evolve rapidly. ABT-450 is a novel potent inhibitor of the non-structural 3/4A protease that has been studied in combination with several agents, allowing shorter duration of therapy and interferon-free/ribavirin-free all-oral regimens. Preliminary data from stu...

journal_title：Expert opinion on pharmacotherapy

authors： Carrion AF,Gutierrez J,Martin P

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Asthma is the most common chronic disease in childhood, affecting approximately 10% of all children, and is the leading cause of hospitalization in developed countries. In this paper we aimed to review the evidence on chemical pharmacotherapy for long-term treatment of pediatric asthma, according to the la...

journal_title：Expert opinion on pharmacotherapy

authors： Vitale C,Maglio A,Pelaia C,Vatrella A

更新日期：2017-05-01 00:00:00

abstract：:Migraine is a multifactorial and disabling syndrome often in comorbidity with psychiatric illnesses. Triptans are the first-line treatment in acute attacks and the most effective drugs in various types of migraine. Sumatriptan was the first medication of this group. Thanks to multiple types of formulations that greatl...

journal_title：Expert opinion on pharmacotherapy

authors： Napoletano F,Lionetto L,Martelletti P

更新日期：2014-02-01 00:00:00

abstract：:Valproic acid (VPA) is considered to be a drug of first choice and one of the most frequently-prescribed antiepileptic drugs worldwide for the therapy of generalized and focal epilepsies, including special epileptic. It is a broad-spectrum antiepileptic drug and is usually well tolerated. Rarely, serious complications...

journal_title：Expert opinion on pharmacotherapy

authors： Gerstner T,Bell N,König S

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Treating HIV-infected children remains a challenge due to a lack of treatment options, appropriate drug formulations and, in countries with limited resources, insufficient access to diagnostic tests and treatment. OBJECTIVE:To summarize current data concerning new opportunities to improve the treatment of H...

journal_title：Expert opinion on pharmacotherapy

authors： Van der Linden D,Callens S,Brichard B,Colebunders R

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Olanzapine long-acting injection (OLAI), or olanzapine pamoate , is one of three second generation (SGA) antipsychotics now available in a long-acting formulation. OLAI is a microcrystalline salt of pamoic acid and olanzapine suspended in an aqueous solution that slowly dissociates into the separate compon...

journal_title：Expert opinion on pharmacotherapy

authors： Chue P,Chue J

更新日期：2012-08-01 00:00:00

abstract：:Desvenlafaxine (DESV) is a newer antidepressant, which inhibits serotonin-norepinephrine reuptake neurotransmission, similarly to venlafaxine, milnacipran and duloxetine. It was approved in February 2008 by the FDA for the treatment of major depressive disorder (MDD), based on well-controlled and adequately powered, l...

journal_title：Expert opinion on pharmacotherapy

authors： Pae CU

更新日期：2011-12-01 00:00:00

abstract：:Glatiramer acetate (Copaxone, Teva Pharmaceuticals Ltd) is a collection of immunomodulatory, synthetic polypeptides indicated for the treatment of relapsing-remitting multiple sclerosis (RR MS). Preclinical and clinical studies provide an evolving understanding of the mechanisms by which glatiramer acetate exerts both...

journal_title：Expert opinion on pharmacotherapy

authors： Wolinsky JS

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:The potency, tolerability and convenience of antiretroviral agents have all significantly improved over the past years, making lifelong HIV therapy easier. However, several specific needs are still unmet, including low daily pill burden, friendly metabolic profile, lack of (or few) drug interactions and hi...

journal_title：Expert opinion on pharmacotherapy

authors： Fernández-Montero JV,Vispo E,Soriano V

更新日期：2014-02-01 00:00:00

abstract：:Motor fluctuations are common and distressing for patients with advanced Parkinson's disease. Subcutaneous apomorphine injections can be an extremely valuable adjunctive therapy. In this review, the authors discuss the history, pharmacology, efficacy, safety and proper administration of apomorphine for treating 'off' ...

journal_title：Expert opinion on pharmacotherapy

authors： Haq IU,Lewitt PA,Fernandez HH

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:The intent of this pooled analysis was to determine the relationship between baseline depression symptom severity and treatment response for escitalopram compared to that for other pooled antidepressant medications (citalopram, duloxetine, fluoxetine, paroxetine, sertraline and venlafaxine). METHODS:Data wer...

journal_title：Expert opinion on pharmacotherapy

authors： Kilts CD,Wade AG,Andersen HF,Schlaepfer TE

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. AREAS COVERED:Herein, the authors address the eff...

journal_title：Expert opinion on pharmacotherapy

authors： Dempsey JL,Johns A,Rosko AE,Lazarus HM

更新日期：2019-05-01 00:00:00

abstract：:This editorial considers the use of the first selective oral renin inhibitor, aliskiren, in reducing angiotensin (Ang) II reactivation or aldosterone (ALDO) escape during renin-angiotensin-aldosterone system (RAAS) inhibition. RAAS blockade with angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin recep...

journal_title：Expert opinion on pharmacotherapy

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Tziomalos K,Karagiannis A

更新日期：2007-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Hypertension is a major independent risk factor for kidney disease and for faster renal function loss. Choice of antihypertensive strategies with highest nephroprotective effect is crucial to prevent or reverse progression to end stage renal disease (ESRD). AREAS COVERED IN THIS REVIEW:The pres...

journal_title：Expert opinion on pharmacotherapy

authors： Cravedi P,Ruggenenti P,Remuzzi G

更新日期：2010-11-01 00:00:00

abstract：:Diabetes mellitus is now occurring in epidemic proportions in many countries. Owing to the limited effectiveness of drug prophylaxis of diabetic complications after diabetes has developed, it may be more appropriate to investigate ways to prevent the onset of diabetes. A recent trial published by the Diabetes Preventi...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:EGFR-targeted drugs have been successfully approved in many countries and have demonstrated higher efficacy and lower toxicity than chemotherapy in molecularly defined subgroups of patients. Significant advances in clinical trials and studies focusing on targeted therapies have rapidly developed in Asia. ...

journal_title：Expert opinion on pharmacotherapy

authors： Ke EE,Zhou Q,Wu YL

更新日期：2015-06-01 00:00:00

abstract：:Simplified antiretroviral regimens have been developed with the aim of improving treatment adherence and quality of life of HIV-infected patients. The single-class triple-nucleoside reverse transcriptase inhibitor combination has contributed to the improvement of the management of HIV infection, especially in patients...

journal_title：Expert opinion on pharmacotherapy

authors： Mastroianni CM,d'Ettorre G,Vullo V

更新日期：2006-11-01 00:00:00

abstract：:An increasing need for economic evaluations of non-Hodgkin's lymphoma (NHL) treatments exists. We performed a literature review on the currently available NHL economic evaluations, using PubMed and the Cochrane database. English and Dutch language papers on treatment in adults were selected. A total of 88 publications...

journal_title：Expert opinion on pharmacotherapy

authors： van Agthoven M,Uyl-de Groot CA,Sonneveld P,Hagenbeek A

更新日期：2004-12-01 00:00:00