Management of insomnia in alcohol use disorder.

abstract：BACKGROUND:Obesity has become a global epidemic with recent estimates of > 400 million obese adults. Despite this, there are few safe and effective pharmacological interventions for obesity. Sibutramine is a weight loss agent, for use as an adjuvant to a comprehensive program of calorie restriction, exercise and behavi...

journal_title：Expert opinion on pharmacotherapy

authors： Sharma B,Henderson DC

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Bronchodilators represent the mainstay of symptomatic treatment for chronic obstructive pulmonary disease (COPD). The principal bronchodilator agents are β(2)-agonists, anticholinergics and methylxanthines, used singly or in combination. Indacaterol is a novel long-acting β(2)-agonist for maintenance bronc...

journal_title：Expert opinion on pharmacotherapy

authors： Steiropoulos P,Papanas N,Nena E,Bouros D

更新日期：2012-05-01 00:00:00

abstract：:Introduction: Liposarcomas are a heterogeneous group of soft tissue tumors that arise from adipose tissue and are one of the most common soft tissue sarcomas found in adults. Liposarcomas are subclassified into four subtypes with distinct histologic and biologic features that influence their treatment and management. ...

journal_title：Expert opinion on pharmacotherapy

authors： Suarez-Kelly LP,Baldi GG,Gronchi A

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Diabetic foot ulceration is a serious secondary complication of diabetes mellitus and the most common cause of hospitalization in diabetic patients. The etiology of diabetic foot ulcerations is complex due to their multifactorial nature. Thus, addressing all of the factors involved remains instrumental in ...

journal_title：Expert opinion on pharmacotherapy

authors： Tecilazich F,Dinh T,Veves A

更新日期：2011-03-01 00:00:00

abstract：:Glycosuria is being increasingly recognised as not only a symptom but also as a novel therapeutic approach in the management of type 2 diabetes mellitus (T2DM). This is accomplished through sodium glucose co-transporter 2 (SGLT2) inhibitors. Consequently, the safety and efficacy of these new agents have been thoroughl...

journal_title：Expert opinion on pharmacotherapy

authors： Pafili K,Papanas N

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Postpartum depression (PPD) is a common and serious illness that affects up to 14% of women in the first month after childbirth. We present an update on the pharmacologic treatment of PPD, although there continues to be a lack of large, randomized controlled trials (RCTs). AREAS COVERED:A review of the li...

journal_title：Expert opinion on pharmacotherapy

authors： Kim DR,Epperson CN,Weiss AR,Wisner KL

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Skin and skin structure infections are frequently encountered in clinical practice. Fortunately, these infections usually produce only mild to moderate symptoms and signs. Some, however, are severe and may even be life-threatening. OBJECTIVE:To review the approach to the evaluation and treatment of patients...

journal_title：Expert opinion on pharmacotherapy

authors： Cornia PB,Davidson HL,Lipsky BA

更新日期：2008-04-01 00:00:00

abstract：:Sertraline (Zoloft, Pfizer Inc.) is a selective serotonin re-uptake inhibitor (SSRI) which has been approved by the US FDA for the treatment of premenstrual dysphoric disorder (PMDD). PMDD is a severe form of premenstrual syndrome (PMS) which affects at least 5 - 8% of women of reproductive age. It is characterised by...

journal_title：Expert opinion on pharmacotherapy

authors： Halbreich U,Kahn LS

更新日期：2003-11-01 00:00:00

abstract：INTRODUCTION:Chronic lymphocytic leukemia (CLL) often has an extended disease course. With a median age at diagnosis of 72 years, newer treatment options with less toxicity than standard nucleoside analogue-based regimens are needed. Historically, few therapy options are available once CLL has become refractory to nucl...

journal_title：Expert opinion on pharmacotherapy

authors： Chang JE,Kahl BS

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Obesity is a growing health problem that has numerous comorbidities, including cardiovascular disease (CVD). The multi-disciplinary treatment of obesity now includes the use of pharmacotherapy. When treating patients with obesity and CVD, certain medications may be more appropriate than others. AREAS COVE...

journal_title：Expert opinion on pharmacotherapy

authors： Andrew CA,Saunders KH,Shukla AP,Aronne LJ

更新日期：2019-04-01 00:00:00

abstract：:Non-Hodgkin's lymphomas (NHL) encompass a heterogeneous group of lymphoid malignancies with varying natural histories and prognoses. Recent classifications for NHL have defined distinct lymphoma entities based on morphology, immunophenotype, genetic features, clonal cell lineage and clinical features. These new, more ...

journal_title：Expert opinion on pharmacotherapy

authors： Tan BR,Bartlett NL

更新日期：2000-03-01 00:00:00

abstract：:Diabetes mellitus is now occurring in epidemic proportions in many countries. Owing to the limited effectiveness of drug prophylaxis of diabetic complications after diabetes has developed, it may be more appropriate to investigate ways to prevent the onset of diabetes. A recent trial published by the Diabetes Preventi...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:Breast cancer (BC) remains the most frequently diagnosed cancer and the most common cause of cancer death among women of all races worldwide. Over 80% of BC cases are hormone receptor (HR)-positive, comprised of luminal A and luminal B per molecular subtypes, imposing an urgent need to fully understand the...

journal_title：Expert opinion on pharmacotherapy

authors： Duso BA,Trapani D,Viale G,Criscitiello C,D'Amico P,Belli C,Mazzarella L,Locatelli M,Minchella I,Curigliano G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:This study examined the effects of short-term administration of the sodium glucose cotransporter 2 (SGLT-2) inhibitor, dapagliflozin, on visceral fat area (VFA) in Japanese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:In this randomized, crossover, controlled clinical trial, overweight patient...

journal_title：Expert opinion on pharmacotherapy

authors： Kato K,Suzuki K,Aoki C,Sagara M,Niitani T,Wakamatsu S,Yanagi K,Aso Y

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the effect of aliskiren and amlopidine on ankle-foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP). RESEARCH DESIGN AND METHODS:After 4-week placebo, 120 outpatients with grade 1 - 2 hypertension were randomized to amlodipine 10 mg or aliskiren 300 mg or t...

journal_title：Expert opinion on pharmacotherapy

authors： Fogari R,Zoppi A,Mugellini A,Maffioli P,Lazzari P,Monti C,Derosa G

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:PI3K inhibition with idelalisib (at that time CAL-101) was at the forefront of the development of molecularly targeted therapies in Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) and follicular lymphoma. However, after initial approval, subsequent trials identified specific immune-medi...

journal_title：Expert opinion on pharmacotherapy

authors： Kienle DL,Stilgenbauer S

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Treatment options for hair disorders are generally very limited. These options are even more limited in children due to the lack of trials and clinical research. Moreover, physicians are sometimes scared to treat children with drugs without safety data, especially because most hair disorders are benign. A...

journal_title：Expert opinion on pharmacotherapy

authors： Iorizzo M,Oranje AP

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Disturbances in lipid metabolism represent an integral component of dysglycemic states and may increase the risk of diabetic complications. Although from a pathophysiological viewpoint fibrates could represent the ideal drug for patients with diabetic dyslipidemia the evidence that support their use in the...

journal_title：Expert opinion on pharmacotherapy

authors： Tsimihodimos V,Mikhailidis DP,Elisaf M

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:During the past decade, there have been significant advances in the pharmacotherapies for the treatment of diabetic macular edema (DME). Among the presently available treatment options, anti-vascular endothelial growth factors (anti-VEGF) agents are the most favored agents due to their efficacy and safety....

journal_title：Expert opinion on pharmacotherapy

authors： Agarwal A,Parriott J,Demirel S,Argo C,Sepah YJ,Do DV,Nguyen QD

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Nonadherence is still a major problem in the long-term treatment of schizophrenia. Long-acting injectable or depot atypical antipsychotics are associated with better maintenance. Olanzapine pamoate, available since 2010, is the second depot atypical antipsychotic. AREAS COVERED:This review covers data on ...

journal_title：Expert opinion on pharmacotherapy

authors： Naber D

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Patients with advanced pancreatic cancer (APC) refractory to first-line therapy have a dismal prognosis and limited therapeutic options, with only one option consisting of nanoliposomal irinotecan in combination with fluorouracil and folinic acid which was approved by FDA based upon results of the phase II...

journal_title：Expert opinion on pharmacotherapy

authors： Passero FC Jr,Saif MW

更新日期：2017-10-01 00:00:00

abstract：:Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify assoc...

journal_title：Expert opinion on pharmacotherapy

authors： Stamer UM,Stüber F

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:In non-exacerbation chronic obstructive pulmonary disease (COPD) with mild lung function impairment, single bronchodilator therapy might be as effective as combined inhaled corticosteroid/bronchodilator therapy, whereas the risk of pneumonia associated with the latter would be practically absent. AREAS CO...

journal_title：Expert opinion on pharmacotherapy

authors： Ruxandra U,Antoniu SA,Mihaltan F,Boisteanu D

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Hypertension is highly prevalent in patients with end-stage kidney disease on hemodialysis and is often not well controlled. Blood pressure (BP) levels before and after hemodialysis have a U-shaped relationship with cardiovascular and all-cause mortality. Although antihypertensive drugs are recommended for...

journal_title：Expert opinion on pharmacotherapy

authors： Maruyama T,Takashima H,Abe M

更新日期：2020-07-01 00:00:00

abstract：:The Ras-Raf-MEK-ERK pathway is a ubiquitously expressed signalling module that regulates the proliferation, differentiation and survival of cells. This pathway features several oncogenes and is deregulated in approximately 30% of all human cancers. Thus, it has emerged as a prime target for antitumour therapy. Drugs t...

journal_title：Expert opinion on pharmacotherapy

authors： Kolch W

更新日期：2002-06-01 00:00:00

abstract：:Candesartan is a long-acting angiotensin receptor antagonist that is well absorbed from the gastrointestinal tract, with insurmountable receptor binding abilities. Recent studies have shown candesartan to be an effective therapy for heart failure patients, producing a significant reduction in mortality and morbidity. ...

journal_title：Expert opinion on pharmacotherapy

authors： McKelvie RS

更新日期：2006-10-01 00:00:00

abstract：INTRODUCTION:With growing knowledge of the molecular pathway of carcinogenesis, targeted therapies have become the 'blue ocean' of cancer treatment. sorafenib is an oral multikinase inhibitor that targets Raf/mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (ERK) (Raf/MEK/ERK) and several ty...

journal_title：Expert opinion on pharmacotherapy

authors： Woo HY,Heo J

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Historically, there were few effective and durable treatments for metastatic melanoma. Recently, mutation based targeted therapies have revolutionized treatment and outcomes for patients with metastatic melanoma. Specifically, inhibitors aimed at BRAF, NRAS, and C-KIT mutations are now commonly used in tre...

journal_title：Expert opinion on pharmacotherapy

authors： Turner MC,Rossfeld K,Salama AK,Tyler D,Beasley G

更新日期：2017-04-01 00:00:00

abstract：:A randomized Phase III trial tested the efficacy of pemetrexed as maintenance treatment in patients with advanced non-small-cell lung cancer (NSCLC) who were without progression after completing four cycles of first-line platinum-based chemotherapy. The primary endpoint of the trial was progression-free survival (PFS)...

journal_title：Expert opinion on pharmacotherapy

authors： Gridelli C,Di Maio M

更新日期：2010-02-01 00:00:00

abstract：:Osteoporosis is a severe condition, associated with significant disability as a result of fragility fractures and increased mortality. Oral bisphosphonates effectively reduce the risk of osteoporotic fracture and are generally well tolerated. Unfortunately, patient outcomes are often compromised by suboptimal therapeu...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY

更新日期：2005-10-01 00:00:00