Targeting CGRP for the Prevention of Migraine and Cluster Headache: A Narrative Review.

abstract：OBJECTIVE:To evaluate the sensitivity of the new International Classification of Headache Disorders-2nd edition (ICHD-II) criteria in the diagnosis of childhood migraine and to propose specific criteria for the diagnosis of childhood migraine. BACKGROUND:In 2004, ICHD-II was adopted by the International Headache Socie...

journal_title：Headache

authors： Hershey AD,Winner P,Kabbouche MA,Gladstein J,Yonker M,Lewis D,Pearlman E,Linder SL,Rothner AD,Powers SW

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To explore the effects of olmesartan on frequency and severity of migraine attacks in patients with comorbid hypertension and prehypertension. BACKGROUND:A randomized, double-blind, placebo-controlled, crossover study with a total of 60 patients has demonstrated the efficacy and safety of the angiotensin II ...

journal_title：Headache

authors： Charles JA,Jotkowitz S,Byrd LH

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:This cross-sectional study on a randomly drawn population sample of children and adolescents (n = 3399; aged 9 to 15) aimed at the assessment of patterns of associations between psychosocial variables and primary headache disorders like migraine (MIG) or tension-type headache. A headache-free group served as ...

journal_title：Headache

authors： Kröner-Herwig B,Gassmann J

更新日期：2012-10-01 00:00:00

abstract：:This multicenter, double-blind, clinical study was designed to compare the efficacy and safety of alpha-dihydroergocryptine and flunarizine in the prophylaxis of migraine without aura. One hundred thirty-five patients fulfilling the diagnostic criteria of the International Headache Society were enrolled at five neurol...

journal_title：Headache

authors： Bussone G,Cerbo R,Martucci N,Micieli G,Zanferrari C,Grazzi L,Fabbrini G,Cavallini A,Granella F,Ambrosoli L,Mailland F,Poli A,Manzoni G

更新日期：1999-06-01 00:00:00

abstract：:The CBF studies performed so far during attacks of migraine, may be interpreted as favouring "the vascular theory." This applies to migraine with aura as well as to migraine without aura. Migraine without aura may be due to mild focal CBF reduction--too mild to be detected by the available CBF techniques (i.e. 20% or ...

journal_title：Headache

authors： Skyhøj Olsen T

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Medication-overuse headache (MOH) refers to headache attributed to excessive use of acute medications. The role of personality needs studies to explain the shifting from drug use to drug abuse. The main aim of this study is to study personality, according to Minnesota Multiphasic Personality Inventory, compa...

journal_title：Headache

authors： Galli F,Pozzi G,Frustaci A,Allena M,Anastasi S,Chirumbolo A,Ghiotto N,Guidetti V,Matarrese A,Nappi G,Pazzi S,Quartesan R,Sances G,Tassorelli C

更新日期：2011-09-01 00:00:00

abstract：:Significant progress in molecular genetics has advanced our understanding of the genetic basis of migraine. The fundamentals of molecular genetics, and the recent advances in the field, are important for clinicians to understand, as they provide a foundation for critical appraisal of the literature, unprecedented insi...

journal_title：Headache

authors： Silberstein SD,Dodick DW

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Migraine can be disabling, but it varies greatly in frequency and intensity between individuals. It is not clear which clinical features have the greatest impact on a migraineur's quality of life. OBJECTIVE:To determine the influence of headache intensity and frequency on headache-related disability. METHO...

journal_title：Headache

authors： Magnusson JE,Becker WJ

更新日期：2003-11-01 00:00:00

abstract：:Topiramate is a neuromodulatory compound with stabilizing properties that was initially introduced for the management of partial seizures. Topiramate has been demonstrated to modify several receptor-gated and voltage-sensitive ion channels, including voltage-activated Na+ and Ca2+ channels and non-NMDA receptors. Thes...

journal_title：Headache

authors： White HS

更新日期：2005-04-01 00:00:00

abstract：:A 6-year-old boy with a family history of hemiplegic migraine had a hemiplegic migraine lasting for 6 days complicated by prolonged fever, lethargy, and two brief focal seizures. An acute single photon emission computerized tomogram (SPECT) demonstrated decreased blood flow in the symptomatic cerebral hemisphere as we...

journal_title：Headache

authors： Crawford JS,Konkol RJ

更新日期：1997-10-01 00:00:00

abstract：:A subcutaneous injection of 6 mg sumatriptan rapidly and effectively stopped attacks of cluster headache. After a time lag of 4-14 minutes (mean 7 minutes) pain dramatically dropped to zero within seconds to single minutes (mean 56 seconds). This rapid effect may indicate that mere vasoconstriction is the mechanism be...

journal_title：Headache

authors： Hardebo JE

更新日期：1993-01-01 00:00:00

abstract：:This study examined the relationship between the menstrual cycle, the stress process, and migraines. Women migraineurs (N = 12) and a matched control sample (N = 12) completed a set of questionnaires assessing stress, appraisal, and coping at premenses, menses, and ovulation. In addition, migraineurs completed a month...

journal_title：Headache

authors： Holm JE,Bury L,Suda KT

更新日期：1996-10-01 00:00:00

abstract：:The drug discovery programs that led to the development of the triptans were determined by the membership of the American Headache Society to be the most important breakthrough in headache medicine in the last 50 years. Dr. Humphrey, who spearheaded the drug discovery, recounts the pioneering work that took place and ...

journal_title：Headache

authors： Humphrey PP

更新日期：2008-05-01 00:00:00

abstract：:We studied 11 patients undergoing a routine lumbar puncture to determine if there were cerebrospinal fluid leaks at the puncture site and whether the maximum volume of leakage correlates with a lumbar puncture headache. Patients completed a headache questionnaire before and after the lumbar puncture. Limited magnetic ...

journal_title：Headache

authors： Iqbal J,Davis LE,Orrison WW Jr

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVES:To compare the relative tolerability of 5-HT1B/1D agonists and to investigate the relationships (if any) among systemic exposure, lipophilicity, and clinical tolerability for 5-HT1B/1D agonists. METHODS:Post hoc correlations were sought among the following variables: absolute dose (= administered dose x ora...

journal_title：Headache

authors： Fox AW

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To assess the degree of debilitation and the treatment views of individuals with headache presenting to a community pharmacy. BACKGROUND:Migraine and chronic daily headache are common poorly managed illnesses. Pharmacists recommend an over-the-counter "headache product" to customers more than 53 000 times da...

journal_title：Headache

authors： Wenzel RG,Schommer JC,Marks TG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Migraine is a common and often debilitating neurological disease. It can be divided into episodic and chronic subforms based on the number of monthly headache days. Because only a subset of individuals with episodic migraine (EM) progress to chronic migraine (CM) over any given time period, understanding the...

journal_title：Headache

authors： Buse DC,Greisman JD,Baigi K,Lipton RB

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Migraine is a common primary headache disorder occurring predominantly in a young, relatively healthy population. RESULTS:There is a growing literature on associations between migraine, especially migraine with aura, and ischemic stroke as well as other vascular events. Migraine as a risk factor for vascula...

journal_title：Headache

authors： Murinova N,Krashin DL,Lucas S

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Migraine occurs in 3% to 5% of young children and up to 18% of adolescents. Management requires a tailored regimen of pharmacological and behavioral measures that consider the headache burden and disability. Patients with frequent or disabling attacks (or both) may warrant preventive agents. OBJECTIVE:To in...

journal_title：Headache

authors： Lewis DW,Diamond S,Scott D,Jones V

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The progression and remission of migraine and the risk factors that determine the course of illness have been intensively studied for the past decade. METHODS:In this fourth paper in a series of methodological articles, we summarize crucial issues that influence studies of migraine clinical course, and sugg...

journal_title：Headache

authors： Lipton RB,Penzien DB,Turner DP,Smitherman TA,Houle TT

更新日期：2013-06-01 00:00:00

abstract：:Episodic cluster headache is a well-recognized entity usually starting in the second decade of life. Uncommonly, the first typical symptoms may present in the first decade of life, but are rarely recognized as such during childhood. We report a 12-year-old girl who presented with a 1-year history of bouts of right-sid...

journal_title：Headache

authors： Neubauer D,Kuhar M,Ravnik IM

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Mechanical compression of the trigeminal root by an artery is thought to cause trigeminal neuralgia. The 5-HT(1B/1D) receptor agonist may inhibit neurogenic inflammation and vasodilation near the irritated trigeminal root. OBJECTIVE:To examine the effectiveness of a 5-HT(1B/1D) receptor agonist, sumatriptan...

journal_title：Headache

authors： Kanai A,Saito M,Hoka S

更新日期：2006-04-01 00:00:00

abstract：:A 57-year-old woman presented with an escalation of her headaches which ultimately progressed to multiple strokes and death. MRI/MRA demonstrated diffuse vasospasm and other causes of stroke were excluded on premortem investigation and postmortem examination. Reversible MRI abnormalities, vasospasm on angiogram and fa...

journal_title：Headache

authors： Marshall N,Maclaurin WA,Koulouris G

更新日期：2007-02-01 00:00:00

abstract：:Migraine is a debilitating condition characterized by a cycle of painful headaches and headache-related symptoms interspersed with periods of worry, distress, and apprehension. The negative impact of migraine on patient functioning, workplace productivity, and other daily activities has been demonstrated through the u...

journal_title：Headache

authors： Kaniecki R

更新日期：2008-04-01 00:00:00

abstract：:Individual differences in pain sensitivity have long remained a perplexing and challenging clinical problem. How can one individual have a sensory experience that is vastly different than that of another, even when they have received similar sensory input? Developing an understanding of such differences and the mechan...

journal_title：Headache

authors： Coghill RC

更新日期：2010-10-01 00:00:00

abstract：:Recently, it has become obvious that disabling postoperative headache is a major problem with acoustic neuroma surgery. A questionnaire was used to retrospectively evaluate the incidence, clinical features, prognosis and possible therapeutic measures of this particular form of headache. Forty-two percent (42%) of pati...

journal_title：Headache

authors： Vijayan N

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:To describe a standardized methodology for the performance of peripheral nerve blocks (PNBs) in the treatment of headache disorders. BACKGROUND:PNBs have long been employed in the management of headache disorders, but a wide variety of techniques are utilized in literature reports and clinical practice. MET...

journal_title：Headache

authors： Blumenfeld A,Ashkenazi A,Napchan U,Bender SD,Klein BC,Berliner R,Ailani J,Schim J,Friedman DI,Charleston L 4th,Young WB,Robertson CE,Dodick DW,Silberstein SD,Robbins MS

更新日期：2013-03-01 00:00:00

abstract：:Respiratory sinus arrhythmia is regarded as indicative of cardiac vagal integrity. A ratio of the longest R-R interval to the shortest R-R interval during deep breathing test (E:I ratio) was calculated in controls (n = 49), cluster headache (n = 33) and CPH (n = 4) patients. E:I ratio decreased with age but was not de...

journal_title：Headache

authors： Kruszewski P

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the role of the chemokine receptor CX3CR1 in headaches and migraine. METHODS:Distribution of 2 polymorphisms of the chemokine receptor CX3CR1 (V249I and T280M) was determined in a population-based sample of 1179 elderly individuals. RESULTS:Heterozygotes for both CX...

journal_title：Headache

authors： Combadière C,Godin O,Vidal C,Cangialosi A,Proust C,Tzourio C

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the course of headache in patients with moderate-to-severe headache due to aneurysmal subarachnoid hemorrhage (aSAH) and to identify its predisposing factors. BACKGROUND:Little is known about the long-term course of headache in patients with aSAH. METHODS:Since Sep...

journal_title：Headache

authors： Hong CK,Joo JY,Kim YB,Shim YS,Lim YC,Shin YS,Chung J

更新日期：2015-07-01 00:00:00