Molecular pharmacology of topiramate: managing seizures and preventing migraine.

Abstract:

:Topiramate is a neuromodulatory compound with stabilizing properties that was initially introduced for the management of partial seizures. Topiramate has been demonstrated to modify several receptor-gated and voltage-sensitive ion channels, including voltage-activated Na+ and Ca2+ channels and non-NMDA receptors. These receptors have been implicated in the pathophysiology of both epilepsy and migraine. The pharmacological mechanisms of action for topiramate that may explain its antiepileptic and migraine preventive activities will be discussed in this review. In addition, the potential relationship between the molecular activities of topiramate and its efficacy in epilepsy and migraine prevention will be emphasized.

journal_name

Headache

journal_title

Headache

authors

White HS

doi

10.1111/j.1526-4610.2005.4501006.x

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

S48-56

eissn

0017-8748

issn

1526-4610

pii

HED4501006

journal_volume

45 Suppl 1

pub_type

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