Abstract:
:Topiramate is a neuromodulatory compound with stabilizing properties that was initially introduced for the management of partial seizures. Topiramate has been demonstrated to modify several receptor-gated and voltage-sensitive ion channels, including voltage-activated Na+ and Ca2+ channels and non-NMDA receptors. These receptors have been implicated in the pathophysiology of both epilepsy and migraine. The pharmacological mechanisms of action for topiramate that may explain its antiepileptic and migraine preventive activities will be discussed in this review. In addition, the potential relationship between the molecular activities of topiramate and its efficacy in epilepsy and migraine prevention will be emphasized.
journal_name
Headachejournal_title
Headacheauthors
White HSdoi
10.1111/j.1526-4610.2005.4501006.xkeywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
S48-56eissn
0017-8748issn
1526-4610pii
HED4501006journal_volume
45 Suppl 1pub_type
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