Abstract:
BACKGROUND:Migraine is a common and often debilitating neurological disease. It can be divided into episodic and chronic subforms based on the number of monthly headache days. Because only a subset of individuals with episodic migraine (EM) progress to chronic migraine (CM) over any given time period, understanding the factors that predict the new onset of CM or "migraine progression" may provide insights into the mechanisms, pathophysiology, prevention, and treatment of CM. In this review, we identify and summarize studies that report risk factors associated with the new onset of CM or related chronic headache diagnoses, group these risk factors and report the strength of evidence for the identified risk factors. OBJECTIVE:To conduct a systematic review of studies that identify risk factors for the new onset of CM or related chronic headache diagnoses such as transformed migraine (TM) and chronic daily headache (CDH). METHODS:Herein we summarize the findings of studies of risk factors associated with the new onset of CM/TM, CDH, or related diagnoses from the English language literature published before March 2018. The PubMed database was searched for relevant studies. Longitudinal studies with follow-up data and case-control studies were included in this qualitative synthesis. We report methodology, analytic criteria, and results for each manuscript and for the parent study. Next, we review the strength of evidence for each of the identified risk factors using a modified version of AB Hill's criteria for causation and rank evidence as fair, moderate, or strong. We categorized risk factors as nonmodifiable, modifiable and based on putative mechanisms. We further categorized risk factors into sociodemographics, lifestyle factors and habits, headache features, comorbid and concomitant diseases and conditions and pharmacologic treatment-related. Finally, we review theories of the pathophysiology underlying the development of new onset chronic migraine or increasing attack frequency. RESULTS:The PubMed search yielded 1870 records after duplicates were removed. Nine additional records were identified through expert consultation and other methods (eg, citations found as references in manuscripts identified in the literature review and through communication with the authors of manuscripts included in the review). The 1879 manuscripts were screened against the inclusion and exclusion criteria and 109 were found to be potentially eligible. Of 109 full-text articles, 17 studies were identified as meeting the prespecified criteria based on the consensus of all authors. Of the 17 full texts, 13 were longitudinal cohort studies and 4 were case-controlled studies. We found strength of evidence ranging from fair to strong for the identified risk factors. The strongest data were found for increased headache day frequency, depression, and medication overuse/high-frequency use. Risk factors for new onset CM and CDH in children and adolescents were similar to those identified in adults. CONCLUSIONS:A range of risk factors for the new onset of CM/TM, CDH, or related chronic headache diseases were identified with the strongest data supporting increased headache day frequency, acute medication overuse/high-frequency use and depression, which are potentially modifiable risk factors. Modifiable risk factors may provide targets for intervention. The lack of strong evidence or any evidence does not imply that there is not a relationship between a particular risk factor and new onset CM or related disease; but may indicate little or no research or that research did not have sufficient methodological rigor. In addition, it is likely that additional risk factors exist which have not yet been identified. Putative factors include pro-inflammatory states and pro-thrombotic states. Development of central sensitization and increased activation of the trigeminal nociceptive pathways may be drivers of the new onset of CM or CDH. Future research may include the systematic testing of interventions targeting modifiable risk factors to determine if progression can be prevented as well as continued exploration of the benefits of treating these risk factors among people with CM in an effort to increase rates of remission. Future work should also consider the natural fluctuations in headache day frequency and examine progression in terms of continuous definitions rather than or in addition to a dichotomous boundary.
journal_name
Headachejournal_title
Headacheauthors
Buse DC,Greisman JD,Baigi K,Lipton RBdoi
10.1111/head.13459subject
Has Abstractpub_date
2019-03-01 00:00:00pages
306-338issue
3eissn
0017-8748issn
1526-4610journal_volume
59pub_type
杂志文章相关文献
HEADACHE文献大全abstract::Seventy-six patients with vascular (migraine or mixed migraine and tension) headache (HA) participated in a controlled evaluation of a minimal-therapist-contact, largely home-based, treatment program which combined relaxation (R) training with thermal biofeedback (TBF). One group received TBF + R administered in 3 off...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.1990.hed3006371.x
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:To describe the occurrence of cerebral venous thrombosis in a 40-year-old man whose cerebral event was induced by a poor golf swing, to review the literature on possible mechanisms producing venous thrombosis, and to compare this case with the literature. BACKGROUND:Headache is the most frequent symptom in ...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1046/j.1526-4610.2000.00093.x
更新日期:2000-07-01 00:00:00
abstract::Many patients with migraine believe weather is a trigger for their headaches. The objective of this study was to determine if very low frequency sferics, pulse-shaped electromagnetic fields originating from atmospheric discharges (lightning), are precipitating factors. The occurrence of sferics impulses is characteriz...
journal_title:Headache
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Persistent migraine aura without infarction (PMA) is a rare condition that is defined as an aura that lasts longer than 1 week in absence of infarction. Two types of PMA have been distinguished, notably persistent primary visual disturbance (PPVD) and typical aura (TA). OBJECTIVES:This case-based review art...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12392
更新日期:2014-09-01 00:00:00
abstract::The Monks of Athos in Greece constitute a particular group with unusual sleep schedule and specific diet. In order to study the frequency of headache among them, a special questionnaire was designed. Four hundred forty-nine monks below the age of 50 were approached, 39 of whom suffered from frequent (more than one epi...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1994.hed3409539.x
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVES/BACKGROUND:We herein investigated the role of polymorphisms in calcitonin gene-related peptide (CGRP)-related genes looking at the association of rs3781719 (T > C) in the calcitonin gene-related polypeptide-alpha (CALCA) gene and of rs3754701 (T > A) and rs7590387 (C > G) at the receptor activity modifying 1...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12559
更新日期:2015-05-01 00:00:00
abstract::Discrimination toward people living with migraine and other headache disorders is widespread and socially accepted. Stigma toward these diseases is both a manifestation of these discriminatory attitudes and a sustainer of them. For those living with migraine and headache disorders, stigma limits the full expression of...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13913
更新日期:2020-10-01 00:00:00
abstract::To test the influence of arterial O2 saturation (SaO2) on heart rate in cluster headache, changes in pulse rate induced by hyperoxia and hypoxia were monitored in 11 cluster headache patients (6 during cluster period, and 5 during remission). The results were compared with those obtained in 11 age and sex matched heal...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1994.hed3402079.x
更新日期:1994-02-01 00:00:00
abstract::Significant progress in molecular genetics has advanced our understanding of the genetic basis of migraine. The fundamentals of molecular genetics, and the recent advances in the field, are important for clinicians to understand, as they provide a foundation for critical appraisal of the literature, unprecedented insi...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12156
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To assess physician-patient communication about headache-related disability and to evaluate the influence of information about disability on physicians' perceptions of illness severity and the treatment needs of migraineurs. BACKGROUND:Evidence suggests that migraine is suboptimally treated in clinical pract...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2001.111006343.x
更新日期:2001-04-01 00:00:00
abstract::A self-administered questionnaire covering the diagnostic criteria of the International Headache Society was completed by 1208 undergraduates of the National University of Singapore to determine the prevalence and characteristics of headaches in this population. The relationship between headaches and depressive illnes...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1997.3701026.x
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:The primary objective of the TEENZ Study (NCT01211145) was to assess the efficacy of zolmitriptan nasal spray in the acute treatment of adolescent migraine patients (ages 12 to 17 years), as measured by the primary outcome variable of pain-free status at 2 hours post-treatment. METHODS:This randomized, doubl...
journal_title:Headache
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/head.12859
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:Our objectives were to determine if: (1) patients with migraine have B wave abnormalities in comparison to normal controls and patients with chronic tension headache and (2) patients with chronic tension headache have an imbalance in autonomic activity that is reflected in differences in Mayer wave activity ...
journal_title:Headache
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::Two adults presented with new-onset migrainous-type visual disturbances and had angiographically demonstrated filling defects near the torcular Herophili. Neither patient had a visual field deficit nor cerebral computed tomography evidence of an occipital infarction. The association of migraine-like visual phenomena w...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1989.hed2902082.x
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Neuromodulators such as topiramate (TPM) and divalproex sodium (DVS) are effective in the preventive treatment of migraine. Nonetheless, patients often discontinue their use due to side effects. OBJECTIVES:The study aims to determine whether the combination of lower doses of TPM and DVS may be useful for pa...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2011.02035.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To review the scope of the problem facing individuals with migraine who are under- or uninsured. In this first of a 2-part narrative review, we will explore migraine epidemiology and the challenges that face this vulnerable population. BACKGROUND:Implementation of the Affordable Care Act has improved access ...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.13286
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:A new form of headache, Headache attributed to aeroplane travel (AH), has been recognized within the International Classification of Headache Disorders 3 beta (ICHD-3beta). In 8 out of 85 AH cases we identified the coexistence of a headache with identical features of AH, but appearing during the rapid descen...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12766
更新日期:2016-02-01 00:00:00
abstract::Interictal serum levels of serotonin and plasma and mononuclear cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/day) and compared with a ...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1046/j.1526-4610.1996.3602091.x
更新日期:1996-02-01 00:00:00
abstract::In a period of one year (1990) we selected 40 patients suffering from migraine. For an open randomized study there were 2 groups of patients: the first were treated with 10mg of flunarizine per day and the second with 3 mg per day. The patients were treated for 4 months consecutively. There were 11 drop outs (27.5%): ...
journal_title:Headache
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1526-4610.1992.hed3208390.x
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease who need dialysis often have poor quality of life. Dialysis headache is a frequent complication of hemodialysis and is often a challenge for nephrologists, neurologists, and headache specialists. METHOD:This was a narrative review. RESULTS:The prevalence of dialysis hea...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12875
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Epidemiological studies support the association between migraine, especially migraine with aura, and vascular disorders. The ankle-brachial index (ABI) is largely used as a surrogate of peripheral obstructive arterial disorders (POAD). Accordingly, in this study we contrasted the ABI in individuals with migr...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01536.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To examine test-retest reliability of magnetic suppression of perceptual accuracy (MSPA) prior to its use as a marker of cortical excitability in a trial of migraine prophylactic agents. BACKGROUND:MSPA is a relatively novel avenue of research in headache, providing an opportunity to study cortical responsi...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.2005.00243.x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The sequence and timing of taking migraine medications, whether prescription or over-the-counter, and the patient's response to their treatment, is unknown. OBJECTIVE:To describe the use of, response to, and satisfaction with acute medications for 1 migraine attack. METHODS:We performed a clinic-based surv...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00437.x
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Migraine is frequently comorbid with major depressive disorder, the presence of which confers increased disability and various clinical challenges. METHODS/RESULTS:The present article reviews empirically supported pharmacologic and cognitive-behavioral interventions for depression, as well as the emerging y...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12521
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To compare, using a within-woman analysis, the severity, duration, and relapse of menstrual vs nonmenstrual episodes of migraine during treatment with usual migraine therapy. BACKGROUND:Studies comparing the clinical characteristics of menstrual and nonmenstrual migraine attacks have yielded conflicting resu...
journal_title:Headache
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1526-4610.2010.01625.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To assess the measurement properties of the Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQv2.1) electronic patient-reported outcome (ePRO) Role Function-Restrictive (RFR) domain to evaluate the functional impact of migraine in patients with episodic (EM) or chronic migraine (CM) enrolled in...
journal_title:Headache
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/head.13497
更新日期:2019-05-01 00:00:00
abstract::A questionnaire study on headaches, using a door-to-door survey, was carried out in a representative sample of the general Greek population, including 1737 men and 1764 women, from 15 to 75 years of age. The parameters evaluated included age, sex, education, socioeconomic status, region of domicile, frequency of heada...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3603168.x
更新日期:1996-03-01 00:00:00
abstract::This review aims to understand the prevalence of premonitory symptoms in migraine, postulate their mechanisms, and compare these with functional imaging studies. A thorough literature review was conducted using PubMed for prevalence studies of premonitory symptoms in migraine and functional imaging studies in the prem...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12572
更新日期:2015-05-01 00:00:00
abstract::Headache centers have to deal with patients suffering from headache induced by chronic substance use which is a well-recognized complication of migraine treatment. The objective of this study was to compare psychiatric comorbidity between migraineurs with and without chronic substance use: 34 migrainous inpatients wit...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1999.3907477.x
更新日期:1999-07-01 00:00:00
abstract::We performed greater occipital nerve blocks on 24 migraineurs with unilateral migraine and trigeminal nerve distribution allodynia. Using a visual analog scale for migraine pain, brush allodynia in the trigeminal nerve distribution and photophobia were reduced 64%, 75%, and 67%, respectively, after 5 minutes. Allodyni...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01146.x
更新日期:2008-07-01 00:00:00