Magnetic field-induced intermediate quantum spin liquid with a spinon Fermi surface.

abstract：:Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veesler D,Spinelli S,Mahony J,Lichière J,Blangy S,Bricogne G,Legrand P,Ortiz-Lombardia M,Campanacci V,van Sinderen D,Cambillau C

更新日期：2012-06-05 00:00:00

abstract：:Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) is known to induce t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin KM,Hu W,Troutman TD,Jennings M,Brewer T,Li X,Nanda S,Cohen P,Thomas JA,Pasare C

更新日期：2014-01-14 00:00:00

abstract：:Aortic endothelial cells from normal pigs and pigs with von Willebrand disease have been established in long-term cultures. Both cultures appeared similar in terms of general growth characteristics, morphologic features and ultrastructure. Immunofluorescent staining of these cultures with chicken (or rabbit) antiporci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Booyse FM,Quarfoot AJ,Bell S,Fass DN,Lewis JC,Mann KG,Bowie EJ

更新日期：1977-12-01 00:00:00

abstract：:Vertebrate hearing and balance are based in complex asymmetries of inner ear structure. Here, we identify retinoic acid (RA) as an extrinsic signal that acts directly on the ear rudiment to affect its compartmentalization along the anterior-posterior axis. A rostrocaudal wave of RA activity, generated by tissues surro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bok J,Raft S,Kong KA,Koo SK,Dräger UC,Wu DK

更新日期：2011-01-04 00:00:00

abstract：:Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial role in these behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saunderson EA,Spiers H,Mifsud KR,Gutierrez-Mecinas M,Trollope AF,Shaikh A,Mill J,Reul JM

更新日期：2016-04-26 00:00:00

abstract：:The epothilones represent a promising class of natural product-based antitumor drug candidates. Although these compounds operate through a microtubule stabilization mechanism similar to that of taxol, the epothilones offer a major potential therapeutic advantage in that they retain their activity against multidrug-res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou TC,Zhang X,Zhong ZY,Li Y,Feng L,Eng S,Myles DR,Johnson R Jr,Wu N,Yin YI,Wilson RM,Danishefsky SJ

更新日期：2008-09-02 00:00:00

abstract：:The bifunctional Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) both aminoacylates mitochondrial tRNA(Tyr) and acts as a structure-stabilizing splicing cofactor for group I introns. Previous studies showed that CYT-18 has distinct tRNA(Tyr) and group I intron-binding sites, with the latter fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paukstelis PJ,Lambowitz AM

更新日期：2008-04-22 00:00:00

abstract：:Individual proteins can now often be modified with atomic precision, but there are still major obstacles to connecting proteins into larger assemblies. To direct protein assembly, ideally, peptide tags would be used, providing the minimal perturbation to protein function. However, binding to peptides is generally weak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fierer JO,Veggiani G,Howarth M

更新日期：2014-04-01 00:00:00

abstract：:By incorporating a population number regulating mechanism into the formulation of genic selection involving a pair of alleles (A1 and A2) with respective frequencies x and I-x, it is shown that the change of x in one generation is given by deltax = sx(1-x)/W, in which W is the mean absolute selective value (in Wright'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura M

更新日期：1978-04-01 00:00:00

abstract：:Criegee intermediates are thought to play a role in atmospheric chemistry, in particular, the oxidation of SO2, which produces SO3 and subsequently H2SO4, an important constituent of aerosols and acid rain. However, the impact of such oxidation reactions is affected by the reactions of Criegee intermediates with water...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HL,Chao W,Lin JJ

更新日期：2015-09-01 00:00:00

abstract：:Sulfonated gallium(III) corroles are intensely fluorescent macrocyclic compounds that spontaneously assemble with carrier proteins to undergo cell entry. We report in vivo imaging and therapeutic efficacy of a tumor-targeted corrole noncovalently assembled with a heregulin-modified protein directed at the human epider...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agadjanian H,Ma J,Rentsendorj A,Valluripalli V,Hwang JY,Mahammed A,Farkas DL,Gray HB,Gross Z,Medina-Kauwe LK

更新日期：2009-04-14 00:00:00

abstract：:Interfacial zones between tissues provide specialized, transitional junctions central to normal tissue function. Regenerative medicine strategies focused on multiple cell types and/or bi/tri-layered scaffolds do not provide continuously graded interfaces, severely limiting the integration and biological performance of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JE,Burns KL,Le Doux JM,Guldberg RE,García AJ

更新日期：2008-08-26 00:00:00

abstract：:The all-cis hexose D-allose, fed to hamster fibroblast cultures over 14-20 hr, brings about a striking down-regulation of hexose transport. This down-regulation by allose is inhibited by 2,4-dinitrophenol. By using D-[14C]allose and thin-layer chromatography, two types of products accumulated that have been identified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ullrey DB,Kalckar HM

更新日期：1991-02-15 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) tuberculosis (TB) highlights the urgent need to understand the mechanisms of resistance to the drugs used to treat this disease. The aminoglycosides kanamycin and amikacin are important bactericidal drugs used to treat MDR TB, and resistance to one or both of these drugs is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaunbrecher MA,Sikes RD Jr,Metchock B,Shinnick TM,Posey JE

更新日期：2009-11-24 00:00:00

abstract：:The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of menstruation-associated toxic shock syndrome (TSS). In this work, we show that the human vaginal isolate Lactobacillus reuteri RC-14 produces small signaling mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Wang W,Xu SX,Magarvey NA,McCormick JK

更新日期：2011-02-22 00:00:00

abstract：:Changes in protein function can lead to changes in the selection acting on specific residues. This can often be detected as evolutionary rate changes at the sites in question. A maximum-likelihood method for detecting evolutionary rate shifts at specific protein positions is presented. The method determines significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knudsen B,Miyamoto MM

更新日期：2001-12-04 00:00:00

abstract：:Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Although antiretroviral the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crakes KR,Santos Rocha C,Grishina I,Hirao LA,Napoli E,Gaulke CA,Fenton A,Datta S,Arredondo J,Marco ML,Sankaran-Walters S,Cortopassi G,Giulivi C,Dandekar S

更新日期：2019-12-03 00:00:00

abstract：:Human diploid fibroblasts (HDFs) possess Ca(2+)-dependent membrane currents. These currents were suppressed in late-passage normal (senescent) HDFs and prematurely senescent HDFs derived from a subject with Werner syndrome (WS), compared with early-passage normal (young) HDFs. When young HDFs were microinjected with m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Thweatt R,Lumpkin CK Jr,Goldstein S

更新日期：1994-03-15 00:00:00

abstract：:Agrobacterium tumefaciens can transfer part of its Ti plasmid, the T-DNA, to plant cells where it integrates into the nuclear genome via illegitimate recombination. Integration of the T-DNA results in small deletions of the plant target DNA, and may lead to truncation of the T-DNA borders and the production of filler ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundock P,Hooykaas PJ

更新日期：1996-12-24 00:00:00

abstract：:Huntington's disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and the important role o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dargaei Z,Bang JY,Mahadevan V,Khademullah CS,Bedard S,Parfitt GM,Kim JC,Woodin MA

更新日期：2018-02-13 00:00:00

abstract：:Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult. We have studied the importance of phosphatidylinositol-3' kinase (PI3K) signaling in these responses by mutating the PI3K-binding sites in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heuchel R,Berg A,Tallquist M,Ahlén K,Reed RK,Rubin K,Claesson-Welsh L,Heldin CH,Soriano P

更新日期：1999-09-28 00:00:00

abstract：:It is becoming common practice to partition glass-forming liquids into two classes based on the dependence of the shear viscosity η on temperature T. In an Arrhenius plot, ln η vs 1/T, a strong liquid shows linear behavior whereas a fragile liquid exhibits an upward curvature [super-Arrhenius (SA) behavior], a situati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallamace F,Branca C,Corsaro C,Leone N,Spooren J,Chen SH,Stanley HE

更新日期：2010-12-28 00:00:00

abstract：:The output of the cerebellar cortex is controlled by two main inputs, (i.e., the climbing fiber and mossy fiber-parallel fiber pathway) and activations of these inputs elicit characteristic effects in its Purkinje cells: that is, the so-called complex spikes and simple spikes. Target neurons of the Purkinje cells in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoebeek FE,Witter L,Ruigrok TJ,De Zeeuw CI

更新日期：2010-05-04 00:00:00

abstract：:In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals that the GTPCHI decame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maita N,Okada K,Hatakeyama K,Hakoshima T

更新日期：2002-02-05 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12] mRNA levels are induced by physiologic concentrations of insulin in cultured 3T3-F442A adipocyte and H35 hepatoma cell lines. To examine the mechanism by which insulin regulates GAPDH mRNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alexander MC,Lomanto M,Nasrin N,Ramaika C

更新日期：1988-07-01 00:00:00

abstract：:We have used germ-line transformation to dissect the cis regulatory elements responsible for the transcriptional control of an internally marked Drosophila chorion gene (s15-P) during development. A 73-base-pair segment of the proximal 5'-flanking DNA contains sequences essential for the tissue-specific expression and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mariani BD,Lingappa JR,Kafatos FC

更新日期：1988-05-01 00:00:00

abstract：:Peer review is the main institution responsible for the evaluation and gestation of scientific research. Although peer review is widely seen as vital to scientific evaluation, anecdotal evidence abounds of gatekeeping mistakes in leading journals, such as rejecting seminal contributions or accepting mediocre submissio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siler K,Lee K,Bero L

更新日期：2015-01-13 00:00:00

abstract：:A change in the conformation of the active site of scallop myosin under the influence of regulatory amounts of Ca2+ has been identified by use of the ADP photoaffinity analog 2-[(4-azido-2-nitrophenyl)amino]ethyl diphosphate (NANDP). NANDP, trapped at the active site with Mn2+ and vanadate, photolabeled preferentially...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kerwin BA,Yount RG

更新日期：1993-01-01 00:00:00

abstract：:A rapid method for quantitating products of the oligodeoxynucleotide processing reaction in vitro has been developed to facilitate enzymatic studies of the retroviral integrases. Unlike earlier procedures, this assay does not depend on polyacrylamide gel electrphoresis but separates products by batch adsorption to PEI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller B,Jones KS,Merkel GW,Skalka AM

更新日期：1993-12-15 00:00:00

abstract：:Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after retinal det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trichonas G,Murakami Y,Thanos A,Morizane Y,Kayama M,Debouck CM,Hisatomi T,Miller JW,Vavvas DG

更新日期：2010-12-14 00:00:00