Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia.

abstract：BACKGROUND:Pediatric health-related quality of life (HRQOL) questionnaires have been validated in children with sickle cell disease (SCD), but small sample sizes in these studies have limited clinical comparisons. We used the baseline clinical data from the Collaborative Data (C-Data) Project of the Comprehensive Sickl...

journal_title：Pediatric blood & cancer

authors： Dampier C,Lieff S,LeBeau P,Rhee S,McMurray M,Rogers Z,Smith-Whitley K,Wang W,Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium (CTC).

更新日期：2010-09-01 00:00:00

abstract：:Osteosarcoma is the most common bone tumor in children and young adults, with few advances in survival and treatment, especially for metastatic disease, in the last 30 years. Recently, immunotherapy has begun to show promise in various adult cancers, but the utility of this approach for osteosarcoma remains relatively...

journal_title：Pediatric blood & cancer

authors： Wedekind MF,Wagner LM,Cripe TP

更新日期：2018-09-01 00:00:00

abstract：:The provision of tele-practice symptom management is often without the provision of evidence-based guidelines. Under the auspices of the Pediatric Oncology Group of Ontario, a nursing task force was established to appraise the evidence and develop guidelines. Promising new efforts to enhance symptom management through...

journal_title：Pediatric blood & cancer

authors： Tsimicalis A,De Courcy MJ,Di Monte B,Armstrong C,Bambury P,Constantin J,Dagelman B,Eves M,Jansen P,Honeyford L,Stregger D,Pediatric Oncology Group of Ontario.

更新日期：2011-10-01 00:00:00

abstract：:Time-to-antibiotic administration (TTA) has been suggested as a quality-of-care (QOC) measure for pediatric oncology patients with febrile neutropenia (FN). Unknown, however, is to what extent pediatric oncology centers utilize TTA. Therefore, we designed and administered an electronic survey (68% response rate) of pr...

journal_title：Pediatric blood & cancer

authors： McCavit TL,Winick N

更新日期：2012-02-01 00:00:00

abstract：:The fundamental purposes underlying formal health care transition from the pediatric to adult setting for young adult survivors of childhood cancer are to facilitate the continuous, medically and developmentally appropriate implementation of risk-based guidelines for the monitoring and management of late effects of ch...

journal_title：Pediatric blood & cancer

authors： Freyer DR,Brugieres L

更新日期：2008-05-01 00:00:00

abstract：:We evaluated the effects of body mass index (BMI) on the risk of thromboembolism (TE) in children (<18 years) with hematological malignancies during the period 1990-2009 (n = 359). Obesity was prevalent in 12% of patients: 6% versus 17% prior to and after the year 2000 (P = 0.02). Sixty-one (17%) patients developed TE...

journal_title：Pediatric blood & cancer

authors： Tuckuviene R,Christensen AL,Chan AK,Athale U

更新日期：2012-08-01 00:00:00

abstract：:Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...

journal_title：Pediatric blood & cancer

authors： Barr RD,Antillón Klussmann F,Baez F,Bonilla M,Moreno B,Navarrete M,Nieves R,Peña A,Conter V,De Alarcón P,Howard SC,Ribeiro RC,Rodriguez-Galindo C,Valsecchi MG,Biondi A,Velez G,Tognoni G,Cavalli F,Masera G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare disease, frequently affecting young children. PROCEDURE:We performed a retrospective study in patients younger than 16 years old manifesting with skin symptoms, and documented their different cutaneous lesions and systemic symptoms. We compared subgroups of chil...

journal_title：Pediatric blood & cancer

authors： Morren MA,Vanden Broecke K,Vangeebergen L,Sillevis-Smitt JH,Van Den Berghe P,Hauben E,Jacobs S,Van Gool SW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Central nervous system irradiation (CNS-RT) has played a central role in the cure of acute lymphoblastic leukemia (ALL), but due to the risk of long-term toxicity, it is now considered a less-favorable method of CNS-directed therapy. PROCEDURES:Retrospectively, we estimated the effect of CNS involvement and...

journal_title：Pediatric blood & cancer

authors： Taskinen M,Oskarsson T,Levinsen M,Bottai M,Hellebostad M,Jonsson OG,Lähteenmäki P,Schmiegelow K,Heyman M

更新日期：2017-02-01 00:00:00

abstract：:Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute ...

journal_title：Pediatric blood & cancer

authors： Esparza O,Xavier AC,Atkinson TP,Hill BC,Whelan K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The hallmark of sickle cell disease (SCD) is recurrent, painful vaso-occlusive episodes (VOC) and is the most common reason for hospitalization in SCD patients. Narcotics, particularly morphine, along with fluid hydration are standard treatments for painful episodes but have been associated with the developm...

journal_title：Pediatric blood & cancer

authors： Buchanan ID,Woodward M,Reed GW

更新日期：2005-10-15 00:00:00

abstract：:Poverty is an important patient-reported outcome of therapy and a potential predictor of outcome disparities in pediatric cancer. We previously identified that nearly 30% of pediatric cancer families experience household material hardship (HMH), a concrete measure of poverty including food, energy, or housing insecuri...

journal_title：Pediatric blood & cancer

authors： Bilodeau M,Ma C,Al-Sayegh H,Wolfe J,Bona K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Solid pseudopapillary pancreatic tumors (SPPT) are an extremely rare entity in pediatric patients. Even if the role of radical surgical resection as primary treatment is well established, data about follow-up after pancreatic resection in children are scant. METHODS:A retrospective review of data from the I...

journal_title：Pediatric blood & cancer

authors： Crocoli A,Grimaldi C,Virgone C,De Pasquale MD,Cecchetto G,Cesaro S,Bisogno G,Cecinati V,Narciso A,Alberti D,Ferrari A,Dall'Igna P,Spada M,Inserra A

更新日期：2019-03-01 00:00:00

abstract：:Hepatoblastoma (HB) and biliary atresia (BA) are both rare conditions that occurred in the patient described. This is the second such case in the literature. An explanation for this apparent coincidence could possibly be found in the existance of pluripotent liver stem cells. In humans, small epithelial cells (SEC) be...

journal_title：Pediatric blood & cancer

authors： Taat F,Bosman DK,Aronson DC

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:Palliative radiation therapy (pRT) is often used to improve quality of life for pediatric patients. Though palliative doses are generally lower than those for cure, pRT may still introduce undesirable effects. The decision to pursue additional therapy for a child may be challenging and depends on parents' kn...

journal_title：Pediatric blood & cancer

authors： Lee BK,Boyle PJ,Zaslowe-Dude C,Wolfe J,Marcus KJ

更新日期：2020-01-01 00:00:00

abstract：:Thymic epithelial neoplasms consist of thymomas, thymic carcinoids, and thymic carcinomas. Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia. They constitute only 4%-14% of thymic epithelial neoplams. Thymic carcinoma rarely occurs in children. Research in the English literat...

journal_title：Pediatric blood & cancer

authors： Yaris N,Nas Y,Cobanoglu U,Yavuz MN

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PHTN) is a potentially life-threatening complication, detected by echocardiographic evidence of elevated tricuspid regurgitant velocity (TRV). This condition has been described in adults with sickle cell disease (SCD) and other hemolytic disorders; however, there is little information...

journal_title：Pediatric blood & cancer

authors： Ambrusko SJ,Gunawardena S,Sakara A,Windsor B,Lanford L,Michelson P,Krishnamurti L

更新日期：2006-12-01 00:00:00

abstract：:Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemothera...

journal_title：Pediatric blood & cancer

authors： Gatz SA,Thway K,Mandeville H,Kerawala C,MacVicar D,Chisholm J

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Ewing tumors are the most frequent malignant tumors of the chest wall in children and young adults. Surgical management of these tumors can be challenging. Optimal local control remains controversial. The aim of this study was to analyze treatment, outcome, and surgical procedures in patients with thoracic t...

journal_title：Pediatric blood & cancer

authors： Seitz G,Urla C,Sparber-Sauer M,Schuck A,Vokuhl C,Blank B,Klingebiel T,Kazanowska B,Fuchs J,Koscielniak E

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The identification of hemophagocytosis (HPC) in tissue or bone marrow (BM) represents only one of 5/8 criteria needed for the diagnosis of hemophagocytic lymphohistiocytosis (HLH). Yet, confirmation of HPC in bone marrow aspirates (BMA) is often relied upon to make therapeutic decisions. There is no standard...

journal_title：Pediatric blood & cancer

authors： Gupta A,Tyrrell P,Valani R,Benseler S,Weitzman S,Abdelhaleem M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that SLCO1B1 c.521T > C variant decreases the clearance of methotrexate (MTX) and elevates its plasma concentration, hence leucovorin doses may need to be adjusted. However, high leucovorin doses may affect the cure rate in childhood acute lymphoblastic leukemia (ALL). Hitherto neither...

journal_title：Pediatric blood & cancer

authors： Zhang HN,He XL,Wang C,Wang Y,Chen YJ,Li JX,Niu CH,Gao P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Sickle cell disease (SCD) is an important, hidden cause of childhood mortality worldwide. It is most prevalent in sub-Saharan Africa where national newborn screening programs remain unavailable and most children in rural areas are never diagnosed. We conducted a study at a rural district hospital ...

journal_title：Pediatric blood & cancer

authors： Eastburg L,Peckham A,Kawira E,Chirangi B,Adler D,Akungo BD,Smart LR,Ambrose EE

更新日期：2020-11-01 00:00:00

abstract：:The incidence of bone marrow metastasis (BMM) in newly diagnosed Ewing sarcoma (ES) is variable across studies. An optimal staging strategy for detecting BMM is not defined. While bone marrow (BM) biopsy and/or aspirate (BMBA) have been the gold standard, [F-18]fluorodeoxyglucose positron emission tomography (FDG-PET)...

journal_title：Pediatric blood & cancer

authors： Campbell KM,Shulman DS,Grier HE,DuBois SG

更新日期：2021-02-01 00:00:00

abstract：:As increasing numbers of childhood cancer patients are surviving, the long-term complications of the disease and its treatment have become ever more increasingly important. Reduced bone mineral density and increased fracture risk have been reported during and after treatment of children with cancer. The causes of oste...

journal_title：Pediatric blood & cancer

authors： van der Sluis IM,van den Heuvel-Eibrink MM

更新日期：2008-02-01 00:00:00

abstract：:2-Chlorodeoxyadenosine (2-CdA) has been successfully used in children to treat refractory Langerhans cell histiocytosis and juvenile xanthogranuloma (JXG) as salvage therapy. Although 2-CdA is generally well-tolerated, with temporary myelosuppression as the primary dose-limiting toxicity, prolonged myelosuppressive, a...

journal_title：Pediatric blood & cancer

authors： Yamada K,Yasui M,Sawada A,Inoue M,Nakayama M,Kawa K

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Cancer patients undergoing chemotherapy often develop anemia, which can increase the risk for transfusions and fatigue. The recombinant erythropoiesis-stimulating agent darbepoetin alfa can effectively treat chemotherapy-induced anemia (CIA) in adults, but limited data are available regarding its use in pedi...

journal_title：Pediatric blood & cancer

authors： Blumer J,Berg S,Adamson PC,Loew T,Rossi G,Hastings C

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Long-term neuropsychological deficits associated with pediatric cancers and the related treatments have been consistently reported. Whole brain cranial radiation therapy (CRT) is associated with neurocognitive impairment. As a result, physicians are reticent to use CRT in favor of systemic or intrathecal che...

journal_title：Pediatric blood & cancer

authors： Pierson C,Waite E,Pyykkonen B

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:This pilot study was done to determine the feasibility and accuracy of University of Florida/National Cancer Institute (UF/NCI) phantoms and Monte Carlo (MC) retrospective dosimetry and had two aims: (1) to determine the anatomic accuracy of UF/NCI phantoms by comparing 3D organ doses in National Wilms Tumor St...

journal_title：Pediatric blood & cancer

authors： Kalapurakal JA,Gopalakrishnan M,Mille M,Helenowski I,Peterson S,Rigsby C,Laurie F,Jung JW,Fitzgerald TJ,Lee C

更新日期：2018-12-01 00:00:00

abstract：:In Mexico, childhood cancer incidence and mortality have increased in the last decade. Through government actions since 2005, the Popular Medical Insurance (PMI) program for childhood cancer was created. The objective of PMI was to offer early cancer diagnosis, standardized treatment regimens, and numerous pediatric o...

journal_title：Pediatric blood & cancer

authors： Rivera-Luna R,Zapata-Tarres M,Shalkow-Klincovstein J,Velasco-Hidalgo L,Olaya-Vargas A,Finkelstein-Mizrahi N,Cárdenas-Cardós R,Aguilar-Ortiz MR

更新日期：2017-06-01 00:00:00

abstract：:A 6-year-old female was admitted with abdominal pain and a mass in the right abdomen. Her lactose dehydrogenase level was 1,200 IU/L, and neuron specific enolase was 120 ng/ml. Computed tomography scan confirmed a large right renal mass with necrosis. A right radical nephrectomy was performed. The tumor was completely...

journal_title：Pediatric blood & cancer

authors： Maeda M,Tsuda A,Yamanishi S,Uchikoba Y,Fukunaga Y,Okita H,Hata J

更新日期：2008-01-01 00:00:00