Severe persistent bone marrow failure following therapy with 2-chlorodeoxyadenosine for relapsing juvenile xanthogranuloma of the brain.

Abstract:

:2-Chlorodeoxyadenosine (2-CdA) has been successfully used in children to treat refractory Langerhans cell histiocytosis and juvenile xanthogranuloma (JXG) as salvage therapy. Although 2-CdA is generally well-tolerated, with temporary myelosuppression as the primary dose-limiting toxicity, prolonged myelosuppressive, and immunosuppressive effects have been reported. We describe an adolescent patient with refractory multiple central nervous system JXG, with the lesion size markedly reduced after treatment with 2-CdA. However, severe transfusion-dependent bone marrow failure developed after five courses of 2-CdA. He underwent successful bone marrow transplantation from his HLA compatible sister with reduced intensity conditioning.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Yamada K,Yasui M,Sawada A,Inoue M,Nakayama M,Kawa K

doi

10.1002/pbc.23087

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

300-2

issue

2

eissn

1545-5009

issn

1545-5017

journal_volume

58

pub_type

杂志文章
  • Long-term results of the AIEOP LNH-97 protocol for childhood lymphoblastic lymphoma.

    abstract:BACKGROUND:Treatment intensification was considered a suitable strategy to increase the cure rate of lymphoblastic lymphoma (LBL) in children. PROCEDURE:The AIEOP LNH-97 trial was run between 1997 and 2007 for newly diagnosed LBL in patients aged less than 18 years. Treatment schedule was based on the previous, LSA2-L...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/pbc.25469

    authors: Pillon M,Aricò M,Mussolin L,Carraro E,Conter V,Sala A,Buffardi S,Garaventa A,D'Angelo P,Lo Nigro L,Santoro N,Piglione M,Lombardi A,Porta F,Cesaro S,Moleti ML,Casale F,Mura R,d'Amore ES,Basso G,Rosolen A

    更新日期:2015-08-01 00:00:00

  • A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma.

    abstract:BACKGROUND:The potential role of VEGF in osteosarcoma has been evaluated in several studies. The majority of them included heterogeneous and limited series of patients, giving conflicting results. The aim of presented study is to evaluate the prognostic role of VEGF-A in biopsy samples of clinically homogeneous group o...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.23021

    authors: Ługowska I,Woźniak W,Klepacka T,Michalak E,Szamotulska K

    更新日期:2011-07-15 00:00:00

  • Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis.

    abstract::Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20986

    authors: Ridola V,Buonuomo PS,Maurizi P,Putzulu R,Annunziata ML,Pietrini D,Riccardi R

    更新日期:2008-02-01 00:00:00

  • Subcutaneous immunoglobulin replacement following CD19-specific chimeric antigen receptor T-cell therapy for B-cell acute lymphoblastic leukemia in pediatric patients.

    abstract::Twenty-eight patients were maintained on subcutaneous immunoglobulin replacement for persistent B-cell aplasia and agammaglobulinemia following CD19-targeted chimeric antigen receptor T-cell therapy for B-cell lymphoblastic leukemia. Patients were transitioned from intravenous to subcutaneous immunoglobulin replacemen...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28092

    authors: Arnold DE,Maude SL,Callahan CA,DiNofia AM,Grupp SA,Heimall JR

    更新日期:2020-03-01 00:00:00

  • Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group.

    abstract:BACKGROUND:The prognostic impact of central nervous system (CNS) involvement in children with acute myeloid leukemia (AML) has varied in past trials, and controversy exists over the degree of involvement requiring intensified CNS therapy. Two recent Children's Oncology Group protocols, AAML03P1 and AAML0531, directed a...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26612

    authors: Johnston DL,Alonzo TA,Gerbing RB,Aplenc R,Woods WG,Meshinchi S,Gamis AS

    更新日期:2017-12-01 00:00:00

  • Parents' responses to prognostic disclosure at diagnosis of a child with a high-risk brain tumor: Analysis of clinician-parent interactions and implications for clinical practice.

    abstract:BACKGROUND:Previous studies have found that parents of children with cancer desire more prognostic information than is often given even when prognosis is poor. We explored in audio-recorded consultations the kinds of information they seek. METHODS:Ethnographic study including observation and audio recording of consult...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28802

    authors: Bluebond-Langner M,Hall N,Vincent K,Henderson EM,Russell J,Beecham E,Bryan G,Gains JE,Gaze MN,Slater O,Langner RW,Hargrave D

    更新日期:2021-03-01 00:00:00

  • Oral health and dental anomalies in patients treated for leukemia in childhood and adolescence.

    abstract:BACKGROUND:This study was conducted to evaluate oral health and dental anomalies in children treated for acute lymphoblastic leukemia (ALL) and to compare results with those of a group of healthy children matched for sex and age. PROCEDURE:Fifty-six children treated for ALL and 56 healthy controls were examined for de...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22108

    authors: Maciel JC,de Castro CG Jr,Brunetto AL,Di Leone LP,da Silveira HE

    更新日期:2009-09-01 00:00:00

  • Age dependency of primary tumor sites and metastases in patients with Ewing sarcoma.

    abstract:BACKGROUND:The median age of patients with Ewing sarcoma (EwS) at diagnosis is around 14-15 years. Older age is associated with a worse outcome. The correlation of age at diagnosis on sites of disease has not been fully described. OBJECTIVE:The goal of this study was to evaluate the differences in sites of primary tum...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27251

    authors: Worch J,Ranft A,DuBois SG,Paulussen M,Juergens H,Dirksen U

    更新日期:2018-09-01 00:00:00

  • Paediatric and adolescent alveolar soft part sarcoma: A joint series from European cooperative groups.

    abstract:BACKGROUND:Alveolar soft part sarcomas (ASPS) are generally chemo- and radio-resistant mesenchymal tumours, with no standardized treatment guidelines. We describe the clinical behaviour of paediatric ASPS and compare these features to previously reported adult series. PATIENTS AND METHODS:The clinical data of 51 child...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24683

    authors: Orbach D,Brennan B,Casanova M,Bergeron C,Mosseri V,Francotte N,Van Noesel M,Rey A,Bisogno G,Pierron G,Ferrari A

    更新日期:2013-11-01 00:00:00

  • Characterization of karyotypic events and evolution in neuroblastoma.

    abstract:BACKGROUND:Neuroblastoma (NB) is cytogenetically characterized by a number of non-random events. However, knowledge is limited concerning the timing of occurrence and inter-action of many of these events. METHODS:Karyotypic patterns were obtained from a study group of 49 NB tumors that had been analyzed by conventiona...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20179

    authors: Betts DR,Cohen N,Leibundgut KE,Kühne T,Caflisch U,Greiner J,Traktenbrot L,Niggli FK

    更新日期:2005-02-01 00:00:00

  • Recognition of Li Fraumeni syndrome at diagnosis of a locally advanced extremity rhabdomyosarcoma.

    abstract::A contemporaneous presentation of a second breast cancer in a mother and an extremity rhabdomyosarcoma (RMS) in her daughter led to the diagnosis of the Li Fraumeni syndrome (LFS). Although the association between LFS and RMS in young patients is well recognised 1 there are no guidelines as to how this knowledge shoul...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20795

    authors: Trahair T,Andrews L,Cohn RJ

    更新日期:2007-03-01 00:00:00

  • MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL).

    abstract::Acute lymphoblastic leukemia (ALL) is the most common type of pediatric neoplasia. Highly heterogeneous, ALL includes several genetic subtypes with varying clinical outcome. Although, some features are well established as prognostic predictors, the details of the molecular mechanisms underlying different phenotypes ar...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.24167

    authors: de Oliveira JC,Brassesco MS,Scrideli CA,Tone LG,Narendran A

    更新日期:2012-10-01 00:00:00

  • Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.

    abstract:BACKGROUND:The introduction of the United Kingdom Medical Research Council's 10th AML trial (MRC AML 10) protocol incorporating high-dose anthracycline therapy has improved outcome of children with acute myeloid leukemia (AML). In this study, we review the results of childhood AML therapy in a Singapore university hosp...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20834

    authors: Tan RM,Quah TC,Aung L,Liang S,Kirk RC,Yeoh AE

    更新日期:2007-03-01 00:00:00

  • Severe H1N1-associated acute respiratory failure in immunocompromised children.

    abstract:BACKGROUND:Severe pandemic influenza A (H1N1) infection can lead to acute respiratory failure (ARF) with associated high mortality. Children with malignancy may be at higher risk of H1N1-associated ARF because of underlying primary disease or immunosuppression associated with chemotherapy. PROCEDURE:We describe the cl...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22973

    authors: Elbahlawan L,Gaur AH,Furman W,Jeha S,Woods T,Norris A,Morrison RR

    更新日期:2011-10-01 00:00:00

  • Body mass index and thromboembolism in children with hematological malignancies.

    abstract::We evaluated the effects of body mass index (BMI) on the risk of thromboembolism (TE) in children (<18 years) with hematological malignancies during the period 1990-2009 (n = 359). Obesity was prevalent in 12% of patients: 6% versus 17% prior to and after the year 2000 (P = 0.02). Sixty-one (17%) patients developed TE...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.23355

    authors: Tuckuviene R,Christensen AL,Chan AK,Athale U

    更新日期:2012-08-01 00:00:00

  • Multimodality treatment of osteosarcoma: radiation in a high-risk cohort.

    abstract:PURPOSE:Chemotherapy during radiation and/or bone-seeking radioisotope therapy (153-samarium; 1 mCi/kg) during radiation may improve osteosarcoma cancer control. PATIENTS AND METHODS:We analyzed our preliminary radiation experience in high-risk, metastatic, and/or recurrent patients during a consecutive period of 20 m...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21451

    authors: Mahajan A,Woo SY,Kornguth DG,Hughes D,Huh W,Chang EL,Herzog CE,Pelloski CE,Anderson P

    更新日期:2008-05-01 00:00:00

  • End of life in children with cancer: experience at the pediatric oncology department of the istituto nazionale tumori in Milan.

    abstract:BACKGROUND:Coping with end-stage pediatric cancer patients and the related bereavement is a challenge for all the caregivers involved. PROCEDURE:Forty-seven cancer patients who died in 2006 were assessed as concerns the main place of care in the end stage of their disease, their symptoms, the palliative treatments rec...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22284

    authors: Beretta S,Polastri D,Clerici CA,Casanova M,Cefalo G,Ferrari A,Luksch R,Massimino M,Meazza C,Podda MG,Spreafico F,Terenziani M,Bellani FF

    更新日期:2010-01-01 00:00:00

  • Pediatric venous thromboembolism in the United States: a tertiary care complication of chronic diseases.

    abstract:BACKGROUND:Pediatric venous thromboembolism (VTE) is an increasingly common problem. We hypothesized that VTE occurs most commonly in tertiary care settings and that the pattern of associated illnesses may have changed from earlier reports. METHODS:The Kids' Inpatient Database 2006 was utilized to identify children ≤ ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.23388

    authors: Setty BA,O'Brien SH,Kerlin BA

    更新日期:2012-08-01 00:00:00

  • Validation of the school age self-administered pediatric bleeding questionnaire (Self-PBQ) in children aged 8-12 years.

    abstract:BACKGROUND:In the pediatric population, pathologic bleeding is often challenging to identify. The pediatric bleeding questionnaire (PBQ) was developed as a screening tool for von Willebrand disease (VWD) but was designed to be self-completed by children above 12 years of age. The study objective was to determine whethe...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27709

    authors: Bui J,Martyres D,James PD,Grabell J,Wu J,Steele M,Silva M,Rand ML,Blanchette VS,Barrowman N,Klaassen RJ

    更新日期:2019-06-01 00:00:00

  • Langerhans cell histiocytosis masquerading as tuberculosis: a diagnostic dilemma resulting in inappropriate anti-tubercular therapy.

    abstract::Langerhans cell histiocytosis is known to mimic many other conditions. We present two patients where anti-tubercular therapy was instituted when clinical and radiological features suggested tuberculosis. The correct diagnosis of histiocytosis was reached only on further work-up including immunohistochemistry following...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21930

    authors: Sharma P,Dhingra KK,Sural S,Mandal AK,Singh T

    更新日期:2009-07-01 00:00:00

  • Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation.

    abstract:BACKGROUND:The purpose of this study was to evaluate a reduced irradiation dose strategy for newly diagnosed primary central nervous system (CNS) germinomas. METHODS:Twenty patients with histologically diagnosed localized pure germinoma (n = 19) or germinoma with a mature teratoma component (n = 1) received four cycle...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22468

    authors: Khatua S,Dhall G,O'Neil S,Jubran R,Villablanca JG,Marachelian A,Nastia A,Lavey R,Olch AJ,Gonzalez I,Gilles F,Nelson M,Panigrahy A,McComb G,Krieger M,Fan J,Sposto R,Finlay JL

    更新日期:2010-07-15 00:00:00

  • Information provision and information needs in adult survivors of childhood cancer.

    abstract:BACKGROUND:Knowledge about their past medical history is central for childhood cancer survivors to ensure informed decisions in their health management. Knowledge about information provision and information needs in this population is still scarce. We thus aimed to assess: (1) the information survivors reported to have...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24762

    authors: Gianinazzi ME,Essig S,Rueegg CS,von der Weid NX,Brazzola P,Kuehni CE,Michel G,Swiss Paediatric Oncology Group (SPOG).

    更新日期:2014-02-01 00:00:00

  • Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma.

    abstract:BACKGROUND:Progressive/recurrent high-grade and diffuse intrinsic pontine gliomas (DIPGs) are fatal. Treatments targeting molecular pathways critical for these cancers are needed. METHODS:We conducted a phase 1 study (rolling-six design) to establish the safety and maximum tolerated dose (MTD) of dasatinib, an oral pl...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27035

    authors: Broniscer A,Jia S,Mandrell B,Hamideh D,Huang J,Onar-Thomas A,Gajjar A,Raimondi SC,Tatevossian RG,Stewart CF

    更新日期:2018-07-01 00:00:00

  • Late effects in childhood cancer survivors: a review with a framing effect bias?

    abstract::Most publications report the adverse (negative) health issues in childhood cancer survivors. Presenting information to the newly diagnosed patient in a positive manner is advocated, while noting that recurrence is the most likely adverse event. Re-analysis of population-based studies on life-threatening toxicities fro...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.22975

    authors: Fryer C

    更新日期:2011-12-15 00:00:00

  • Use of infliximab-daclizumab combination for the treatment of acute and chronic graft-versus-host disease of the liver and gut.

    abstract::Infliximab-daclizumab was used to treat acute and chronic liver and gut graft-versus-host disease (GVHD) in two children after standard immunosuppressive therapy failed. Infliximab (10 mg/kg weekly, 4 doses) and daclizumab (1 mg/kg, days 1, 4, 8, 15, and 22) were given over 1 month. In case 1, grade 2 chronic GVHD of ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.20648

    authors: Rodriguez V,Anderson PM,Trotz BA,Arndt CA,Allen JA,Khan SP

    更新日期:2007-08-01 00:00:00

  • Histologic survey of neuroblastomas after intensive induction chemotherapy.

    abstract:BACKGROUND:Histology after intensive induction chemotherapy is expected to become a beacon indicating when and how extensively radical surgery and lymph node dissection should be performed in advanced neuroblastoma. A thorough histologic review of surgical specimens was undertaken. PROCEDURE:All specimens from 34 pati...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20345

    authors: Tsuchida Y,Miyauchi J,Kuroiwa M,Suzuki N,Sakamoto J,Suzuki M,Shitara T

    更新日期:2005-10-15 00:00:00

  • Proton therapy for pediatric head and neck malignancies.

    abstract:PURPOSE:Pediatric head and neck malignancies are managed with intensive multimodality therapy. Proton beam therapy (PBT) may reduce toxicity by limiting exposure of normal tissue to radiation. In this study, we report acute toxicities and early outcomes following PBT for pediatric head and neck malignancies. MATERIALS...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26858

    authors: Vogel J,Both S,Kirk M,Chao HH,Bagatell R,Li Y,Womer R,Balamuth N,Reilly A,Kurtz G,Lustig R,Tochner Z,Hill-Kayser C

    更新日期:2018-02-01 00:00:00

  • Neuroblastoma with symptomatic epidural compression in the infant: the AIEOP experience.

    abstract:BACKGROUND:Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay in diagnosis. PATIENTS AND METHODS:Clinical, imaging and follow-up data of 34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at Italian AIEOP centers were ...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/pbc.25028

    authors: De Bernardi B,Quaglietta L,Haupt R,Castellano A,Tirtei E,Luksch R,Mastrangelo S,Viscardi E,Indolfi P,Cellini M,Tamburini A,Erminio G,Gandolfo C,Sorrentino S,Vetrella S,Gigliotti AR

    更新日期:2014-08-01 00:00:00

  • Variation in receipt of opioids by pediatric oncology patients who died in children's hospitals.

    abstract:BACKGROUND:Opioids are a cornerstone of palliation of pain. We sought to assess variation in opioid prescription during the last week of life among a cohort of pediatric oncology patients who died while hospitalized. PROCEDURE:We used detailed hospital administrative data from the Pediatric Health Information System (...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pbc.21824

    authors: Orsey AD,Belasco JB,Ellenberg JH,Schmitz KH,Feudtner C

    更新日期:2009-07-01 00:00:00

  • Prognostic factors and treatment outcome in childhood Hodgkin disease.

    abstract:BACKGROUND:The goals of this study included: (1) Identification of factors prognostic for event-free survival (EFS) and overall survival (OS), and (2) Definition of risk groups for risk adapted therapy in children with Hodgkin disease (HD). PROCEDURE:From 1991 to 2003, 69 children with newly diagnosed, untreated biops...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20487

    authors: Oguz A,Karadeniz C,Okur FV,Citak EC,Pinarli FG,Bora H,Akyurek N

    更新日期:2005-10-15 00:00:00