Abstract:
BACKGROUND:Challenges remain in the judgement of pathological murmurs in newborns at maternity hospitals, and there are still many simple major CHD patients in developing countries who are not diagnosed in a timely fashion. This study aimed to evaluate the accuracy of cardiac auscultation on neonatal CHD by general paediatricians. METHODS:We conducted a prospective study at three hospitals. All asymptomatic newborns underwent auscultation, pulse oximetry monitoring, and echocardiography. Major CHD was classified and confirmed through follow-up. We evaluated the accuracy of various degrees of murmurs for detecting major CHD to determine the most appropriate standards and time of auscultation. RESULTS:A total of 6750 newborns were included. The median age of auscultation was 43 hours. Cardiac murmurs were identified in 6.6% of newborns. For all CHD, 44.4% had varying degrees of murmurs. A murmur of grade ≥2 used as a reference standard for major CHD had a sensitivity of 89.58%. The false positive rate of murmurs of grade ≥2 for detecting major CHD was significantly negatively related to auscultation time, with 84.4% of false positives requiring follow-up for non-major CHD cardiac issues. Auscultation after 27 hours of life could reduce the false positive rate of major CHD from 2.7 to 0.9%. CONCLUSIONS:With appropriate training, maternity hospital's paediatricians can detect major CHD with high detection rates with an acceptable false positive rate.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Zhao QM,Niu C,Liu F,Wu L,Ma XJ,Huang GYdoi
10.1017/S1047951119000799subject
Has Abstractpub_date
2019-05-01 00:00:00pages
679-683issue
5eissn
1047-9511issn
1467-1107pii
S1047951119000799journal_volume
29pub_type
杂志文章,多中心研究abstract:BACKGROUND:The association between long QT interval and sudden infant death syndrome has been clearly established. Several studies have been conducted to determine the evolution of the QT interval in childhood from birth, but only in full-term newborns. However, data on the QT interval in pre-term infants are extremely...
journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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更新日期:2005-04-01 00:00:00
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002400
更新日期:2015-01-01 00:00:00
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journal_title:Cardiology in the young
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
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pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000625
更新日期:2013-04-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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journal_title:Cardiology in the young
pub_type: 杂志文章
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journal_title:Cardiology in the young
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00