Abstract:
BACKGROUND:The association between long QT interval and sudden infant death syndrome has been clearly established. Several studies have been conducted to determine the evolution of the QT interval in childhood from birth, but only in full-term newborns. However, data on the QT interval in pre-term infants are extremely scarce. The objective was to describe the development of the QT interval in premature infants. Material and methods In a prospective monocentric study in a neonatal intensive care unit, pre-term newborns born before 37 weeks of gestation without congenital heart disease, family history of long QT, unstable haemodynamic status, or administration of drugs inducing QT interval prolongation were included with parental consent. An electrocardiogram was recorded in similar conditions weekly until discharge in each child. The corrected QT was calculated with Bazett's formula. RESULTS:In all, 309 echocardiograms were recorded in 87 children, with gestational age ranging from 24-36 weeks. QT first increased after birth in very premature infants - less than 30 weeks of gestation - and then started to decrease, whereas it only decreased in more mature infants. When plotted against postmenstrual age, QT first increased, and then decreased after 32 weeks. Discussion Our data suggest that the QT interval varies with postmenstrual age in very premature infants, reaching a peak at 32 weeks. These developmental changes may induce specific vulnerability to QT-lengthening medications in premature infants. This study underlines the need for specific pharmacological studies in this population.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Séguéla PE,Rozé JC,Gournay Vdoi
10.1017/S1047951111001958subject
Has Abstractpub_date
2012-08-01 00:00:00pages
430-5issue
4eissn
1047-9511issn
1467-1107pii
S1047951111001958journal_volume
22pub_type
杂志文章abstract::Single-nucleotide polymorphisms in miRNA-machinery genes may alter the biogenesis of miRNAs affecting disease susceptibility. In this case-control study, we aimed to evaluate the impact of three single-nucleotide polymorphisms (DICER rs1057035, DROSHA rs10719, and XPO5 rs11077) and their combined effect in a genetic r...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120004874
更新日期:2021-01-11 00:00:00
abstract::We present a rare case of incidentally diagnosed Twiddler's syndrome in a child 7 years after implantation of a dual-chamber pacemaker system with epicardial leads. During revision, an insulation defect of the ventricular lead was evident, despite unremarkable prior pacemaker lead testing. The lead was repaired and a ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120001031
更新日期:2020-06-01 00:00:00
abstract::Infective endocarditis is a microbial infection of the endothelial surface of the heart, predominantly the heart valves, that is associated with high mortality and morbidity. Few contemporary data exist regarding affected children in our context. AIMS AND OBJECTIVES:We aimed to describe the profile and treatment outc...
journal_title:Cardiology in the young
pub_type: 杂志文章,多中心研究
doi:10.1017/S1047951119002154
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to identify incidence, aetiology, and outcomes of extubation failure in infants with shunt-dependent pulmonary blood flow at a single tertiary care, academic children's hospital. The second objective of this study was to determine the haemodynamic effects of transition of positi...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112002181
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:CHD is the leading cause of mortality due to birth defects. Array comparative genomic hybridisation (aCGH) detects submicroscopic copy number changes and may improve identification of the genetic basis of CHD. METHODS:This is a retrospective analysis of 1252 patients from a regional referral centre who had ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001838
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:The policy of early repair of patients with tetralogy of Fallot, irrespective of age, as opposed to initial palliation with a shunt, remains controversial. The aim of our study was to analyze the midterm outcome of primary early correction of tetralogy of Fallot. METHODS:Between 1996 and 2005, a total of 61 ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951108001960
更新日期:2008-04-01 00:00:00
abstract::An acute injury to a coronary artery was recognized during the surgical construction of the Fontan circulation. Surgical manipulation of the site of injury was not successful in restoring normal myocardial blood flow. A stent was therefore placed intraoperatively under direct vision, with restoration of normal coronar...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951104001180
更新日期:2004-02-01 00:00:00
abstract::We describe 3 siblings with muscular ventricular septal defects, two requiring surgical closure. One of their offspring had a rare congenital aneurysm of the muscular ventricular septum, also requiring surgery. Another had a small muscular ventricular septal defect which closed spontaneously. Their father had echocard...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951107000996
更新日期:2007-10-01 00:00:00
abstract::We report an extremely rare case of a 14-month-old girl who was diagnosed with a single right coronary artery with coronary artery fistula communicating with the right ventricle and congenital absence of left coronary artery. Angiography showed a dilated and tortuous single right coronary artery draining into the righ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119002105
更新日期:2019-11-01 00:00:00
abstract:UNLABELLED:Real-time three-dimensional echocardiography can surpass simple cross-sectional echocardiography in providing precise details of cardiac lesions. For the purpose of optimising treatment, we describe our findings with real-time three-dimensional echocardiography when interrogating different types of communica...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001107
更新日期:2012-04-01 00:00:00
abstract::Introduction Neurodevelopmental abnormalities are common in children with CHD and are the highest-priority concerns for parents and professionals following cardiac surgery in childhood. There is no additional routine monitoring of development for children with CHD in the United Kingdom; hence, neurodevelopmental conce...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117002918
更新日期:2018-04-01 00:00:00
abstract::A non-dysmorphic 10 month old female was discovered at surgery to have severe vasculopathy of both the systemic and pulmonary arteries. These findings were confirmed by pathologic examination. Follow-up angiography has confirmed multiple sites of vascular obstruction which appear to be worsening. Angioplasty has only ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s104795110200063x
更新日期:2002-05-01 00:00:00
abstract::CHD is associated with poor growth, delayed motor and language skills development, and increased length of hospital stay; 28.2% of infants were stunted, with z-scores<-2. The severity of surgery score was not associated with an increased length of stay, suggesting that a low weight-for-age z-score at the time of surge...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001778
更新日期:2016-04-01 00:00:00
abstract::We present a case of a 31-year-old male with a large atrial septal defect, who was found to have interrupted inferior caval vein with azygous continuation to the superior caval vein, which precluded transcutaneous closure by device. The defect was successfully closed with a 33 mm Occlutech Figula septal occluder using...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795112000092X
更新日期:2020-06-01 00:00:00
abstract::Supravalvular aortic stenosis is associated with the Williams-Beuren syndrome, but it also occurs in a non-syndromatic congenital form. An elastin gene mutation of chromosome 7q11.23 is responsible in both cases. The vascular features are identical. These patients have a higher risk of sudden death, particularly when ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110001563
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:The relationship between sildenafil dosing, exposure, and systemic hypotension in infants is incompletely understood. OBJECTIVES:The aim of this study was to characterise the relationship between predicted sildenafil exposure and hypotension in hospitalised infants. METHODS:We extracted information on sild...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001639
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The physiological importance of the lateral tunnel stenosis in the Fontan pathway for children with single ventricle physiology can be difficult to determine. The impact of the stenosis and stent implantation on total cavopulmonary connection resistance has not been characterized, and there are no clear guid...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114002765
更新日期:2016-01-01 00:00:00
abstract::We studied the duration and dispersion of the P wave in patients after a Senning operation, assessing its value in detecting the risk of atrial tachycardias.We measured the duration and dispersion of the wave in surface 12 lead electrocardiograms obtained from 18 patients with sinus rhythm, having a mean age of 12.8 y...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951109991892
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:The initial classic Fontan utilising a direct right atrial appendage to pulmonary artery anastomosis led to numerous complications. Adults with such complications may benefit from conversion to a total cavo-pulmonary connection, the current standard palliation for children with univentricular hearts. METHOD...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111900146X
更新日期:2019-08-01 00:00:00
abstract::Pneumopericardium, defined as air in the pericardial cavity, is a rare condition with potentially severe complications and mortality. In the neonatal period, pneumopericardium is associated with prematurity, very low birth weight, and assisted ventilation. We report the occurrence of spontaneous pneumopericardium in a...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117002657
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To determine styles of coping, that is personal ways of dealing with problems, and social support, or support from the social environment, in a cohort of adults with congenital heart disease. METHODS:We subjected 362 patients with congenital heart disease, aged from 20 to 46 years, belonging to five diagnost...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951104002033
更新日期:2004-04-01 00:00:00
abstract::The neuro-cutaneous syndrome tuberous sclerosis is commonly associated with rhabdomyomas in various organs including the heart. We are reporting a rare case of a 7-month old male child with congenitally corrected transposition of the great arteries associated with tuberous sclerosis and cardiac rhabdomyomas. To our kn...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002047
更新日期:2014-10-01 00:00:00
abstract::Endocarditis of congenital coronary fistulas in the cardiac chambers is rare, especially in the paediatric age group. We describe the case of a 9-year-old boy with a fistula from the dilated right coronary artery to the junction of the superior caval vein to the right atrium, complicated by endocarditis. Treatment con...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001846
更新日期:2018-02-01 00:00:00
abstract::We report an unusual case of a 12-month-old boy diagnosed with anomalous origin of a single coronary artery from the pulmonary artery associated with patent ductus arteriosus. The patient survival was attributed to left-to-right shunt (patent ductus arteriosus) allowing for appropriate myocardial perfusion. Successful...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120001328
更新日期:2020-07-01 00:00:00
abstract::Interest in brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the management of children with CHD has increased. There are, however, no current guidelines for their routine use. The aim of this review article is to provide an update on the data regarding the use of BNP/NT-proB...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951114002133
更新日期:2015-03-01 00:00:00
abstract::Plastic bronchitis is a rare and difficult to treat disease process in patients with congenital heart disease. Cardiac transplantation has been used increasingly to reverse this process, especially in single ventricle physiology. This case report demonstrates a foreseeable complication after cardiac transplantation in...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001066
更新日期:2014-08-01 00:00:00
abstract::Innocent murmurs are common in childhood. They require accurate diagnosis to avoid unnecessary anxiety and/or restrictions. With this in mind, we studied prospectively children diagnosed by a paediatric cardiologist as having innocent murmurs to review the necessity of investigations in excluding organic abnormalities...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s104795110000963x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:Increasing rates of survival have raised the question of medical and psychosocial factors contributing to quality of life of patients with congenital cardiac disease. We investigated the impact of the severity of disease, and social disadvantage, on the quality of life of patients and their primary caregivers...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105002118
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To evaluate long-term outcome of initial aortic valve intervention in a paediatric population with congenital aortic stenosis, and to determine risk factors associated with reintervention. PATIENTS AND METHODS:From 1985 to 2009, 77 patients with congenital aortic stenosis and a mean age of 5.8±5.6 years at ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001085
更新日期:2015-06-01 00:00:00
abstract::A 9-month-old infant presented with fever, dyspnoea, and a murmur. Echocardiography showed a mitral vegetation with significant regurgitation. Mitral valve plasty was performed on day 6, and was polymerase chain reaction positive for Kingella kingae. The cardiac outcome was favourable. This case illustrates a subtle p...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000351
更新日期:2010-08-01 00:00:00