Abstract:
:Interest in brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the management of children with CHD has increased. There are, however, no current guidelines for their routine use. The aim of this review article is to provide an update on the data regarding the use of BNP/NT-proBNP in the evaluation and surgical treatment of children with CHD. BNP/NT-proBNP levels in children with CHD vary substantially according to age, laboratory assay methods, and the specific haemodynamics associated with the individual congenital heart lesion. The accuracy of BNP/NT-proBNP as supplemental markers in the integrated screening, diagnosis, management, and follow-up of CHD has been established. In particular, the use of BNP/NT-proBNP as a prognostic indicator in paediatric cardiac surgery has been widely demonstrated, as well as its role in the subsequent follow-up of surgical patients. Most of the data, however, are derived from single-centre retrospective studies using multivariable analysis; prospective, randomised clinical trials designed to evaluate the clinical utility and cost-effectiveness of routine BNP/NT-proBNP use in CHD are lacking. The results of well-designed, prospective clinical trials should assist in formulating guidelines and expert consensus recommendations for its use in patients with CHD. Finally, the use of new point-of-care testing methods that use less invasive sampling techniques - capillary blood specimens - may contribute to a more widespread use of the BNP assay, especially in neonates and infants, as well as contribute to the development of screening programmes for CHD using this biomarker.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Cantinotti M,Walters HL,Crocetti M,Marotta M,Murzi B,Clerico Adoi
10.1017/S1047951114002133subject
Has Abstractpub_date
2015-03-01 00:00:00pages
424-37issue
3eissn
1047-9511issn
1467-1107pii
S1047951114002133journal_volume
25pub_type
杂志文章,评审abstract:OBJECTIVE:To assess haemodynamic patterns in head-up tilt testing on 400 paediatric cases with unexplained syncope. METHODS:Medical records of 520 children who underwent head-up tilt testing in the preceding year were retrospectively evaluated, and 400 children, 264 (66%) girls and 136 (34%) boys, aged 12.6±2.6 years ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001176
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To examine the clinical utility of the Pediatric Symptom Checklist 17 for identifying psychosocial concerns and improving access to psychology services within a paediatric cardiology clinic. METHOD:Parents of 561 children (aged 4-17 years) presenting for follow-up of CHD, acquired heart disease, or arrhythmi...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001900
更新日期:2016-08-01 00:00:00
abstract::Many, if not most, of the controversies regarding the description of the congenitally malformed heart have been resolved over the turn of the 20th century. A group of lesions that remains contentious is the situation in which both arterial trunks, in their greater part, are supported by the morphologically right ventr...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951116001190
更新日期:2017-01-01 00:00:00
abstract::This study evaluates clinical and epidemiological features of acute rheumatic fever using the data of last 25 years in our hospital in south-east of Turkey. The medical records of 377 patients with acute rheumatic fever admitted to Pediatric Cardiology Department of Çukurova University during 1993-2017 were retrospect...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120001596
更新日期:2020-08-01 00:00:00
abstract::Our long-term follow-up has revealed that symmetrical development of the breasts is significantly impaired in pre-pubescent female patients subsequent to an anterolateral thoracotomy. Although standard posterolateral and anterolateral right-sided thoracotomies are used for correction of "simple" cardiac lesions such a...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Percutaneous treatment of aortic coarctation is a widely used option. Covered stents have increased the profile of efficacy and safety of this procedure. Here we report on a 32-year-old woman with significant aortic recoarctation associated with aortic wall aneurysm and close proximity of both lesions to the origin of...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001061
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors. OBJECTIVE:To determine early markers of left ventricular affection in obese pa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117001627
更新日期:2018-01-01 00:00:00
abstract::Plastic bronchitis is a severe complication after a Fontan procedure, with an estimated incidence around 1-2% and poor prognosis. We present the cases of four patients with plastic bronchitis after a total cavopulmonary connection with a stenosis of the left pulmonary artery that was stented successfully. In three of ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002163
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Holt-Oram syndrome is characterised by CHD and limb anomalies. Mutations in TBX5 gene, encoding the T-box transcription factor, are responsible for the development of Holt-Oram syndrome, but such mutations are variably detected in 30-75% of patients. METHODS:Clinically diagnosed eight Holt-Oram syndrome pat...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001656
更新日期:2015-08-01 00:00:00
abstract::Primary care cardiology, also known as ambulatory or outpatient cardiology, for the longitudinal management of patients with common arterial trunk or with transposition of the great arteries is both poorly described and has limited evidence to justify its basis. This article discusses some of the various complications...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951112001588
更新日期:2012-12-01 00:00:00
abstract::With the increase in long-term survival of post-transplant children, there is a paradigm shift in the emphasis of post-transplant care. We describe de novo cardiovascular abnormalities, which occurred in otherwise asymptomatic paediatric liver transplant recipients, who received liver allografts between 1991 and 2014 ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111800063X
更新日期:2018-08-01 00:00:00
abstract::Information about acute coronary syndrome caused by Kawasaki disease-related coronary artery lesions in adults is sketchy. We reviewed the clinical features of 50 adult patients who had an acute coronary syndrome caused by coronary artery lesions due to Kawasaki disease or probable Kawasaki disease from 1980 to 2008. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110001502
更新日期:2011-02-01 00:00:00
abstract::A 5-year-old girl presented with chronic fatigue and extreme exercise intolerance. After countless doctor visits, investigations, and hospital admissions, striking desaturation during exercise test pointed to a cardiovascular problem. Desaturation as a result of right-to-left shunting through a patent foramen ovale du...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118002044
更新日期:2019-02-01 00:00:00
abstract::Paediatric heart transplantation has evolved over the last 3 decades. The research group, Pediatric Heart Transplant Study, has been in step with that evolution over the nearly 20 years of its existence by utilising its registry to contribute a wealth of clinical research to the field. The highlights of its studies wi...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951115000931
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Postural tachycardia syndrome is more frequently being recognised in adolescents and adults. However, its pathophysiology remains undefined. We evaluated our database for patterns in family history of clinical symptoms and associated disorders in these patients. MATERIALS AND METHODS:Patients with postura...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120000165
更新日期:2020-03-01 00:00:00
abstract::Children with a secundum atrial septal defect are usually asymptomatic and are referred for elective closure after 3-4 years of age; however, in premature infants with chronic lung disease, bronchopulmonary dysplasia, or pulmonary hypertension, increased pulmonary blood flow secondary to a left-to-right atrial shunt, ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114002650
更新日期:2016-01-01 00:00:00
abstract::A 31-year-old patient previously underwent a Mustard operation presented with palpitations. Atrial tachycardia and paroxysmal atrial fibrillation were documented on the surface electrocardiogram. Under the guidance of a three-dimensional electroanatomic mapping system, ablation of the isolated left-sided pulmonary vei...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001851
更新日期:2015-08-01 00:00:00
abstract::Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951115000839
更新日期:2015-08-01 00:00:00
abstract::The neuro-cutaneous syndrome tuberous sclerosis is commonly associated with rhabdomyomas in various organs including the heart. We are reporting a rare case of a 7-month old male child with congenitally corrected transposition of the great arteries associated with tuberous sclerosis and cardiac rhabdomyomas. To our kn...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113002047
更新日期:2014-10-01 00:00:00
abstract::Purpose The aim of this study was to determine whether the exercise tolerance test can provide diagnostic and prognostic information regarding children and young adults and help predict outcome. METHODS:A total of 87 patients, aged 7-29 years (median 13, mean 13.4) were selected retrospectively. They underwent exerci...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117000233
更新日期:2017-09-01 00:00:00
abstract::To determine whether cardiac catheterisation procedures for low birth weight neonatesr < or = 2.5 kg carries a greater risk of complications compared with neonates > 2.5 kg, we conducted a single-centre retrospective case–control study. From 01/03 to 01/09, 46 consecutive neonates < 2.5 kg at the time of cardiac cathe...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112002247
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Tricuspid regurgitation as a manifestation of an isolated congenital anomaly of the tricuspid valve is rare. Cross-sectional and color Doppler echocardiography allow improved evaluation of tricuspid valvar function. As a result, the heterogeneous category of congenital tricuspid valvar dysplasia may be bette...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100004972
更新日期:1999-05-01 00:00:00
abstract::We studied the duration and dispersion of the P wave in patients after a Senning operation, assessing its value in detecting the risk of atrial tachycardias.We measured the duration and dispersion of the wave in surface 12 lead electrocardiograms obtained from 18 patients with sinus rhythm, having a mean age of 12.8 y...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951109991892
更新日期:2009-12-01 00:00:00
abstract::Congenital stenosis of the pulmonary veins is a rare condition whose outcome is guarded despite the available treatment options. We report a case of a 6-month-old infant with significant stenosis of all four pulmonary veins. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119000428
更新日期:2019-05-01 00:00:00
abstract::Severe right ventricular failure complicated a postoperative systemic inflammatory response in a 33-year-old woman after surgical repair of congenital cardiac malformations. Volume loading, and high doses of catecholamines, failed to produce improvement, but treatment with vasopressin improved all haemodynamic paramet...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105000193
更新日期:2005-02-01 00:00:00
abstract::This study was carried out to analyse seasonal variations in live births with congenital heart disease in the overall population of Malta. Included were all patients diagnosed as having congenital heart disease by echocardiography, cardiac catheterization, surgery or post mortem, by 1 year of age, and who were born be...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/s1047951100005205
更新日期:1999-07-01 00:00:00
abstract::CHD is associated with poor growth, delayed motor and language skills development, and increased length of hospital stay; 28.2% of infants were stunted, with z-scores<-2. The severity of surgery score was not associated with an increased length of stay, suggesting that a low weight-for-age z-score at the time of surge...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001778
更新日期:2016-04-01 00:00:00
abstract::We describe 3 siblings with muscular ventricular septal defects, two requiring surgical closure. One of their offspring had a rare congenital aneurysm of the muscular ventricular septum, also requiring surgery. Another had a small muscular ventricular septal defect which closed spontaneously. Their father had echocard...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951107000996
更新日期:2007-10-01 00:00:00
abstract:AIMS:Our aims were to use transthoracic three-dimensional echocardiography to assess the morphology of atrial septal defects in children prior to closure, and to compare the three-dimensional echocardiographic data with transcatheter and surgical findings. METHODS AND RESULTS:We used transthoracic three-dimensional ec...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951103000118
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:We have used the Amplatzer ductal occluder for transcatheter closure of large persistently patent arterial ducts, and used our experience to assess the safety and efficacy of the device in young children and infants. METHODS AND PATIENTS:We used the Amplatzer ductal occluder prospectively in 43 patients wit...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105000570
更新日期:2005-06-01 00:00:00