Abstract：
:Beige adipocytes and brown adipocytes can generate heat by using mitochondrial uncoupling protein 1 (Ucp1), a thermogenic protein. Browning/beiging is the emergence of beige adipocytes in white adipose tissues (WAT) for cold acclimatization. Here we show the existence of brown/beige adipocytes in retro-orbital WAT in mice. Histologically, Ucp1-positive cells with multilocular lipid droplets were abundant in retro-orbital WAT of immature mice; those cells decreased in number with age. However, Ucp1-positive adipocytes with multilocular lipid droplets emerged in retro-orbital WAT in adult mice, due to cold exposure as short as 3 h. Consistent with this observation, the expression level of Ucp1 mRNA was enhanced in tissues upon cold exposure. Furthermore, eye surface temperature remained within a physiological range during cold challenge. RT-qPCR suggested a mixed phenotype of brown and beige adipocytes in retro-orbital WAT. Transmission electron microscopic observation showed multiple lipid droplets and numerous mitochondria with high cristae density in retro-orbital WAT cells from both control and cold-exposed mice. Our results suggest that warming of the orbital cavity by browning/beiging in retro-orbital WAT is a protective mechanism against cold cataract caused by lowered lens temperature.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Sugiyama M,Shindo D,Kanada N,Ohzeki T,Yoshioka K,Funaba M,Hashimoto Odoi
10.1016/j.exer.2019.03.021subject
Has Abstractpub_date
2019-07-01 00:00:00pages
8-14eissn
0014-4835issn
1096-0007pii
S0014-4835(18)30855-8journal_volume
184pub_type
杂志文章abstract：:Glaucoma is a leading cause of irreversible blindness worldwide. Lowering intraocular pressure (IOP) is the only strategy documented to delay the appearance and retard the progression of vision loss. One major approach for lowering IOP is to slow the rate of aqueous humor formation by the ciliary epithelium. As discus...
journal_title：Experimental eye research
pub_type： 杂志文章,评审
doi：10.1016/j.exer.2008.11.005
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abstract：:Preretinal pH was measured in the avascular region of 19 rabbit retinas during alternating cycles of light and dark, using a miniature, needle-type pH electrode. In 14 experiments with the rabbits breathing room air, cyclic changes in pH, decreasing in the dark and increasing in the light, were observed. The transitio...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(91)90106-o
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journal_title：Experimental eye research
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doi：10.1016/j.exer.2005.10.009
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 信件
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2014.09.004
更新日期：2014-11-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1006/exer.2001.1023
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journal_title：Experimental eye research
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更新日期：2013-05-01 00:00:00
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journal_title：Experimental eye research
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更新日期：1983-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2014.02.014
更新日期：2014-04-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.2000.0918
更新日期：2000-12-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/j.exer.2014.07.004
更新日期：2014-10-01 00:00:00
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doi：10.1016/j.exer.2010.02.006
更新日期：2010-05-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1994.1086
更新日期：1994-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(90)90066-4
更新日期：1990-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/j.exer.2006.06.004
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更新日期：2018-11-01 00:00:00
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journal_title：Experimental eye research
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更新日期：1990-01-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1006/exer.1998.0661
更新日期：1999-06-01 00:00:00
