Abstract:
BACKGROUND:The opportunistic pathogen, Pseudomonas aeruginosa is well known for its environmental and metabolic versatility, yet many of the functions of its gene-products remain to be fully elucidated. This study's objective was to illuminate the potential functions of under-described gene-products during the medically relevant copper-stress condition. RESULTS:We used data-independent acquisition mass spectrometry to quantitate protein expression changes associated with copper stress in P. aeruginosa PAO1. Approximately 2000 non-redundant proteins were quantified, with 78 proteins altering in abundance by +/- 1.5-fold or more when cultured to mid-log growth in the presence of 50 μM copper sulfate. One-third of those differentially expressed proteins have no prior established functional roles. CONCLUSIONS:This study provides evidence for the functional involvement of some specific proteins in enabling P. aeruginosa to survive under sub-lethal concentrations of copper. This further paves the way for targeted investigations into the specific mechanisms of their activity.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Wright BW,Kamath KS,Krisp C,Molloy MPdoi
10.1186/s12866-019-1441-7subject
Has Abstractpub_date
2019-04-01 00:00:00pages
69issue
1issn
1471-2180pii
10.1186/s12866-019-1441-7journal_volume
19pub_type
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