Familial hypopituitarism associated with an enlarged pituitary fossa and an empty sella.

abstract：OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

journal_title：Clinical endocrinology

authors： Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

更新日期：2018-09-01 00:00:00

abstract：:The antigenicity of HCG was tested in twenty-three young healthy men receiving two different HCG preparations (A and B). Each subject received 5000 i.u. HCG intramuscularly daily for three consecutive days, followed by another course, 3 weeks later, of 5000 i.u. HCG injections daily for 3 days. Two of the fifteen subj...

journal_title：Clinical endocrinology

authors： Nieschlag E,Bernitz S,Töpert M

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:Cushing's disease (CD) presents a remarkable preponderance in female gender, with a female-to-male ratio of 3-8:1. The aim of this study was to evaluate gender-related differences in the presentation of CD, as regards: biochemical indices of hypercortisolism; sensitivity of diagnostic tests; clinical features...

journal_title：Clinical endocrinology

authors： Zilio M,Barbot M,Ceccato F,Camozzi V,Bilora F,Casonato A,Frigo AC,Albiger N,Daidone V,Mazzai L,Mantero F,Scaroni C

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

journal_title：Clinical endocrinology

authors： Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Leptin serves as a hormonal signal linking food intake and energy expenditure to fat mass. As significant effects of testosterone administration on body composition and adipose tissue have been described recently, we examined a possible association between serum levels of leptin and testosterone which has not...

journal_title：Clinical endocrinology

authors： Behre HM,Simoni M,Nieschlag E

更新日期：1997-08-01 00:00:00

abstract：:The pharmacokinetics, safety and endocrine effects of an authentic human growth hormone (bio-hGH), produced by the expression of genomic hGH in a mammalian cell line, were studied in six healthy young men who were administered 0.2 U/kg/day subcutaneously for five consecutive days. Changes in sodium balance and in thyr...

journal_title：Clinical endocrinology

authors： Ho KY,Weissberger AJ,Stuart MC,Day RO,Lazarus L

更新日期：1989-04-01 00:00:00

abstract：:Twenty women, who had been randomly selected from women with subclinical hypothyroidism identified in a population study were treated with L-thyroxine and placebo in a double-blind cross-over design during 2 x 6 months. Three women did not complete the study, one because she moved to another part of the country, and t...

journal_title：Clinical endocrinology

authors： Nyström E,Caidahl K,Fager G,Wikkelsö C,Lundberg PA,Lindstedt G

更新日期：1988-07-01 00:00:00

abstract：:The possibility of differences in glucocorticoid sensitivity between normal and cystic fibrosis fibroblasts was studied in cultured cells derived from forearm skin biopsies. Both normal and cystic fibrosis cells bound tritiated dexamethasone with high affinity (Kd 37 degrees C approximately equal to 10 nmol/1) to a li...

journal_title：Clinical endocrinology

authors： Khalid BA,Gyorki S,Warne GL,Funder JW

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:It is known that growth hormone can induce accelerated bone turnover in GH deficient people as well as healthy elderly people. In this study we examined the effect of recombinant human GH (rhGH) on bone mineral mass and bone turnover in the presence of the bone resorption inhibiting agent, pamidronate. Effect...

journal_title：Clinical endocrinology

authors： Erdtsieck RJ,Pols HA,Valk NK,van Ouwerkerk BM,Lamberts SW,Mulder P,Birkenhäger JC

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:The metabolites of steroidal hormones, including sulphate, glucuronide, and fatty acid (FA) ester derivatives, have received little attention, although these steroid derivatives are essential components in the global assessment of steroid metabolism. The study of FA-derivatives could, in obesity, contribute s...

journal_title：Clinical endocrinology

authors： Fernández-Real JM,Sanchis D,Ricart W,Casamitjana R,Balada F,Remesar X,Alemany M

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In polycystic ovary syndrome (PCOS) inappropriate gonadotrophin secretion is characterized by increased pulse frequency and amplitude, elevated 24-h mean serum concentrations, and greater responses to GnRH. While the mechanism(s) responsible for this increased release of LH are not well underst...

journal_title：Clinical endocrinology

authors： Patel K,Coffler MS,Dahan MH,Malcom PJ,Deutsch R,Chang RJ

更新日期：2004-01-01 00:00:00

abstract：:Several weeks after thyroidectomy (T), female rats stopped growing, and their pituitary GH content had decreased to less than 2--3% of the values found for age-matched controls (C). The liver membranes of such animals were explored with human GH (hGH). It was found that in the severely hypothyroid T rat, the number, b...

journal_title：Clinical endocrinology

authors： Duran-Garcia S,Gomez-Nieto J,Fouchereau-Peron M,Padron VF,Obregon MJ,Morreale de Escobar G,Escobar del Rey F

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Distinguishing malignant thyroid nodules in patients with follicular cytology by fine-needle aspiration (FNA) remains problematic. The large majority of thyroid nodules (> 85%) are overtreated. Therefore, a clear need exists to develop more accurate initial diagnostic tests for follicular thyroid nodules. Ga...

journal_title：Clinical endocrinology

authors： Hooft L,van der Veldt AA,Hoekstra OS,Boers M,Molthoff CF,van Diest PJ

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Growth hormone deficiency (GHD) in adults has been associated with impaired health status and quality of life (QoL) in several studies using generic measures, and in a few studies using recently developed disease-specific measures. Theoretically, disease-specific measures may be more sensitive and succinct th...

journal_title：Clinical endocrinology

authors： Wirén L,Whalley D,McKenna S,Wilhelmsen L

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Hyperinsulinaemia has a role in the development of hyperandrogenism and polycystic ovary syndrome in women of normal weight. Polycystic ovaries are common in women with bulimia nervosa and this study aimed to determine whether women with bulimia nervosa are insulin resistant and to examine the relation betwee...

journal_title：Clinical endocrinology

authors： Raphael FJ,Rodin DA,Peattie A,Bano G,Kent A,Nussey SS,Lacey JH

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:GH and IGF-I affect cardiac structure and performance. In the general population, low IGF-I has been associated with higher prevalence of ischaemic heart disease and mortality. Both in GH deficiency (GHD) and excess life expectancy has been reported to be reduced because of cardiovascular disease. OBJECTIVE...

journal_title：Clinical endocrinology

authors： Colao A

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion. OBJECTIVE:To investigate the clinical characteristics and accurate management of aromatase-deficient children. PATIENTS AND METHOD...

journal_title：Clinical endocrinology

authors： Fan L,Zhang B,Li L,Gong C

更新日期：2020-12-01 00:00:00

abstract：:The cardiovascular response and the changes of plasma arginine vasopressin (AVP) concentration following graded doses of AVP infused intravenously have been defined in six normal young men. The same measurements were also made during fluid deprivation in a patient with both nephrogenic diabetes insipidus and systemic ...

journal_title：Clinical endocrinology

authors： Khokhar AM,Slater JD,Ma J,Ramage CM

更新日期：1980-09-01 00:00:00

abstract：INTRODUCTION:Growth hormone deficiency is considered the most important factor determining skeletal fragility in hypopituitary patients. Osteoblasts and chondrocytes express growth hormone (GH) receptor. Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment enc...

journal_title：Clinical endocrinology

authors： Mormando M,Chiloiro S,Bianchi A,Giampietro A,Angelini F,Tartaglione L,Nasto L,Milardi D,Formenti AM,Giustina A,De Marinis L

更新日期：2016-11-01 00:00:00

abstract：:In order to investigate the endocrine requirements for induction of follicle maturation, ovulation and luteal function we have measured plasma LH and FSH concentrations in 109 cycles induced by treatment with LHRH in 25 women with amenorrhoea of diverse aetiology. The major clinical and endocrine subgroupings were pol...

journal_title：Clinical endocrinology

authors： Abdulwahid NA,Adams J,van der Spuy ZM,Jacobs HS

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the role of pulsed tissue Doppler (TD) to identify left (LV) and right ventricular (RV) myocardial regional involvement in acromegaly. PATIENTS AND MEASUREMENTS:Thirty active acromegaly patients, free of diabetes mellitus, thyroid dysfunction, valvular and coronary heart d...

journal_title：Clinical endocrinology

authors： Galderisi M,Vitale G,Bianco A,Pivonello R,Lombardi G,Divitiis Od,Colao A

更新日期：2006-04-01 00:00:00

abstract：:We have previously reported that L-thyroxine treated patients may often have elevated serum T4 concentrations and yet show no clinical signs of hyperthyroidism. We found that such patients had normal serum T3 concentrations. The present study explored the relationship between serum T3 and T4 and dosage of L-thyroxine....

journal_title：Clinical endocrinology

authors： Rendell M,Salmon D

更新日期：1985-06-01 00:00:00

abstract：:A new radioreceptor assay for insulin-like growth factor-II (IGF-II), using receptors on ovine placental membranes, is described. Half-maximal displacement of specifically bound radioiodinated human IGF-II tracer was seen at 1.0 ng/tube of unlabelled IGF-II. The cross-reactivity of IGF-I was 1%, and insulin was entire...

journal_title：Clinical endocrinology

authors： Baxter RC,de Mellow JS

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

journal_title：Clinical endocrinology

authors： Ip MS,Tan KC,Peh WC,Lam KS

更新日期：2001-10-01 00:00:00

abstract：CONTEXT & OBJECTIVE:A recent paper by our group reported that regular aerobic exercise during pregnancy led to lower foetal IGF-I and IGF-II concentrations and a modest reduction in offspring birth weight when compared with the offspring of nontraining control participants. Maternal hormonal alterations in response to ...

journal_title：Clinical endocrinology

authors： Hopkins SA,Baldi JC,Cutfield WS,McCowan L,Hofman PL

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Pubertal gynaecomastia is a very common condition. Although the underlying aetiology is poorly understood, it is generally accepted that excess of oestrogens and deficit of androgens are involved in the pathogenesis. Furthermore, adiposity as well as the GH/IGF-I axis may play a role. In this study, we elucid...

journal_title：Clinical endocrinology

authors： Mieritz MG,Sorensen K,Aksglaede L,Mouritsen A,Hagen CP,Hilsted L,Andersson AM,Juul A

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Scalp hair loss is often encountered in clinical practice in Japan after successful surgery for acromegaly. However, this intriguing issue has not been addressed in the literature. The aim of this study was to examine scalp hair loss after surgery for acromegaly. METHODS:Postoperative scalp hair loss was sur...

journal_title：Clinical endocrinology

authors： Yamada S,Fukuhara N,Nishioka H,Yamaguchi-Okada M,Takeshita A,Takeuchi Y

更新日期：2013-09-01 00:00:00

abstract：:The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second...

journal_title：Clinical endocrinology

authors： Wang C,Chan V,Yeung RT

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between serum chemokine CXC ligand 5 (CXCL5) and intima-media thickness (IMT) of the common carotid artery, a marker of preclinical atherosclerosis. DESIGN, PATIENTS AND MEASUREMENTS:We measured the IMT (mean of three segments of both carotid arteries by ultrasonography), serum CXC...

journal_title：Clinical endocrinology

authors： Chen L,Yang Z,Lu B,Li Q,Ye Z,He M,Huang Y,Wang X,Zhang Z,Wen J,Liu C,Qu S,Hu R

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Levothyroxine suppressive therapy (LT4-therapy), aimed at shrinking thyroid nodules is controversial. Despite evidence of limited effect and long-term side-effects, questionnaire surveys indicate widespread use. Our aim was to determine, in consecutive nontoxic goitre patients, the proportion ineligible for L...

journal_title：Clinical endocrinology

authors： Fast S,Bonnema SJ,Hegedüs L

更新日期：2008-10-01 00:00:00