Abstract:
:Elastography-based liver stiffness measurement (LSM) is a non-invasive tool for estimating liver fibrosis but also provides an estimate for the severity of portal hypertension in patients with advanced chronic liver disease (ACLD). The presence of varices and especially of varices needing treatment (VNT) indicates distinct prognostic stages in patients with compensated ACLD (cACLD). The Baveno VI guidelines suggested a simple algorithm based on LSM < 20 kPa (by transient elastography, TE) and platelet count > 150 G/L for ruling-out VNT in patients with cACLD. These (and other) TE-based LSM cut-offs have been evaluated for VNT screening in different liver disease etiologies. Novel point shear-wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) methodologies for LSM have also been evaluated for their ability to screen for "any" varices and for VNT. Finally, the measurement of spleen stiffness (SSM) by elastography (mainly by pSWE and 2D-SWE) may represent another valuable screening tool for varices. Here, we summarize the current literature on elastography-based prediction of "any" varices and VNT. Finally, we have summarized the published LSM and SSM cut-offs in clinically useful scale cards.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Paternostro R,Reiberger T,Bucsics Tdoi
10.3748/wjg.v25.i3.308subject
Has Abstractpub_date
2019-01-21 00:00:00pages
308-329issue
3eissn
1007-9327issn
2219-2840journal_volume
25pub_type
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pub_type: 杂志文章
doi:10.3748/wjg.v20.i5.1348
更新日期:2014-02-07 00:00:00
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
doi:10.3748/wjg.v21.i40.11458
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doi:10.3748/wjg.v18.i25.3260
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pub_type: 杂志文章
doi:10.3748/wjg.v17.i35.4013
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2006-06-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.14.3518
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v19.i35.5925
更新日期:2013-09-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v20.i5.1139
更新日期:2014-02-07 00:00:00
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doi:10.3748/wjg.15.6129
更新日期:2009-12-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v20.i48.18228
更新日期:2014-12-28 00:00:00
abstract::Hepatitis B virus (HBV) is the leading cause of liver disease and infects an estimated 240 million people worldwide. It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication. The ten genotypes (A-J) that have been described so far further segr...
journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v20.i24.7622
更新日期:2014-06-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v19.i43.7813
更新日期:2013-11-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v9.i3.427
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v8.i6.1081
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v16.i35.4428
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
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更新日期:2014-02-21 00:00:00