Abstract:
:Variably expressive copy-number variants (CNVs) are characterized by extensive phenotypic heterogeneity of neuropsychiatric phenotypes. Approaches to identify single causative genes for these phenotypes within each CNV have not been successful. Here, we posit using multiple lines of evidence, including pathogenicity metrics, functional assays of model organisms, and gene expression data, that multiple genes within each CNV region are likely responsible for the observed phenotypes. We propose that candidate genes within each region likely interact with each other through shared pathways to modulate the individual gene phenotypes, emphasizing the genetic complexity of CNV-associated neuropsychiatric features.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Jensen M,Girirajan Sdoi
10.1371/journal.pgen.1007879subject
Has Abstractpub_date
2019-01-17 00:00:00pages
e1007879issue
1eissn
1553-7390issn
1553-7404pii
PGENETICS-D-18-01766journal_volume
15pub_type
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