Abstract:
:Detection and validation of the RNA degradation signals controlling transcriptome stability are essential steps for understanding how cells regulate gene expression. Here we present complete genomic and biochemical annotations of the signals required for RNA degradation by the dsRNA specific ribonuclease III (Rnt1p) and examine its impact on transcriptome expression. Rnt1p cleavage signals are randomly distributed in the yeast genome, and encompass a wide variety of sequences, indicating that transcriptome stability is not determined by the recurrence of a fixed cleavage motif. Instead, RNA reactivity is defined by the sequence and structural context in which the cleavage sites are located. Reactive signals are often associated with transiently expressed genes, and their impact on RNA expression is linked to growth conditions. Together, the data suggest that Rnt1p reactivity is triggered by malleable RNA degradation signals that permit dynamic response to changes in growth conditions.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Gagnon J,Lavoie M,Catala M,Malenfant F,Elela SAdoi
10.1371/journal.pgen.1005000subject
Has Abstractpub_date
2015-02-13 00:00:00pages
e1005000issue
2eissn
1553-7390issn
1553-7404pii
PGENETICS-D-14-01414journal_volume
11pub_type
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